netFormulary
 Report : A-Z of formulary items 04/07/2020 03:20:01
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Section Name Details
13.08.01 5-aminolaevulinic acid Ameluz®

For use with photodynamic therapy (PDT) in Dermatology

05.03.01 Abacavir Ziagen® 300mg Tablets
100mg/5mL Solution

Restricted - must be prescribed by HIV consultants only

05.03.01 Abacavir and Lamivudine  Restricted - must be prescribed by HIV consultants only

Abacavir 600mg/Lamivudine 300mg Film Coated Tablets
05.03.01 Abacavir and Lamivudine and Zidovudine Trizivir® Abacavir 300mg/Lamivuidine 150mg/Zidovudine 300mg

Restricted - must be prescribed by HIV consultants only
10.01.03 Abatacept Orencia® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

125mg Pre-filled Syringe OR pen for sub-cutaneous injection.
250mg injection for IV infusion.

Must be prescribed by a Rheumatology consultant in accordance with NICE TA373 & TA375 for the treatment of rheumatoid and juvenile arthritis.

08.01.05 Abemaciclib Verzenios®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved for use in accordance with the NICE TA below.

08.03.04.02 Abiraterone 250mg Zytiga®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA259 & TA387 for the treatment of metastatic prostate cancer.

04.10.01 Acamprosate Campral EC®

Restricted - only to be prescribed by a specialist in drug and alcohol problems 

06.01.02.03 Acarbose  50mg & 100mg Tablets
11.06 Acetazolamide  500mg Injection
11.06 Acetazolamide  250mg Tablets
250mg Modified Release capsules
11.08.02 Acetylcholine Chloride / Mannitol 1%/3% 
03.07 Acetylcysteine  

Nacsys 600mg Effervescent tablets ONCE a day (lower pill burden than carbocisteine).

Brand prescribe on FP10. Most cost-effective brand is NACSYS.

18 Acetylcysteine 2g/ 10mL  Restricted - for use:
1. In paracetamol overdose and
2. On critical care, and Respiratory wards, via nebulisation as a mucolytic, for ventilated patients at risk of chest sepsis.
03.07 Acetylcysteine 2g/10mL 

Off-label use of the injection.

Most commonly use undiluted injection (20% solution) 3 to 5ml 3 to 4 times daily alternatively 400mg (2ml) mixed with 2mls sodium chloride 0.9% three or four times a day can be used.

11.08.01 Acetylcysteine 5% 
05.03.02.01 Aciclovir  200mg Dispersible Tablets
400mg & 800mg Tablets
200mg/5mL & 400mg/5mL Sugar Free Suspension
05.03.02.01 Aciclovir 250mg, 500mg  N.B. Obese patients should have the dose calculated on ideal bodyweight to prevent excessive dosing.
13.10.03 Aciclovir 5% Zovirax®
13.05.02 Acitretin Neotigason®

10mg & 25mg Capsules

Restricted - Must be prescribed by a Dermatology specialist

03.01.02 Aclidinium Eklira Genuair® Long-acting antimuscarinic

322micrograms per metered dose - Inhalation powder
03.01.04 Aclidinium/ formoterol inhaler Duaklir Genuair ®

Long-acting anti-muscarinic and long-acting beta agonist

Aclidinium 340micrograms/ formoterol 12micrograms - Dry powder inhaler

18 Activated charcoal 50g/240mL

Reduction of absorption of toxic substances by the GI tract that are adsorbed by charcoal.

L&D - Kept in ED antidote cupboard.

BHT - Kept in Accident & Emergency, AAU and Whitbread ward

01.05.03 Adalimumab Imraldi®

Biosimilar brand for all new patients. FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

40mg/0.8mL Pre-filled Pen
40mg/0.8mL Pre-filled Syringe
Restricted to prescribing by NICE criteria or by approved individual funding request (IFR) ONLY.

Refer to NICE TA's above
 

01.05.03 Adalimumab Humira®

Not for new patients - use Imraldi.

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

40mg Pre-filled Pen
40mg Pre-filled Syringe
40mg/0.8mL Injection

Restricted to prescribing by NICE criteria or by approved individual funding request (IFR) ONLY.
 

10.01.03 Adalimumab 40mg Humira®

Not for new patients - use Imraldi.

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Must only be prescribed by Rheumatology Consultant in accordance with NICE TA195 and TA375 for the treatment of rheumatoid arthritis.

10.01.03 Adalimumab 40mg Imraldi®

New biosimilar brand for all new patients

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Must only be prescribed by Rheumatology Consultant in accordance with NICE TA195 and TA375 for the treatment of rheumatoid arthritis.

See NICE TA's above

11.04.02 Adalimumab 40mg Imraldi®

New biosimilar brand for all new patients

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Approved in accordance with NICE TA460 for treating non-infectious uveitis.

11.04.02 Adalimumab 40mg Humira®

Not for new patients - use Imraldi.

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Approved in accordance with NICE TA460 for treating non-infectious uveitis.

13.05.03 Adalimumab 40mg Imraldi®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA146 & TA455.

13.05.03 Adalimumab 40mg Humira® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA146 & TA455.

13.06.01 Adapalene 0.1% 
05.03.03.01 Adefovir Dipivoxil 10mg  Hepsera® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - to prescribing by Consultant Gastroenterologists for hepatitis B in accordance with NICE CG165.

02.03.02 Adenosine Adenocor® Seek specialist Cardiology input
6mg in 2mL Injection
30mg in 10mL Injection
unlicensedunlicensed 120mg in 120mL - Cardiac Centre only
03.04.03 Adrenaline / epinephrine EpiPen® Adult: 300micrograms
Junior:150micrograms

NOTE: Ensure that training is given to all patients, for all prescriptions, irrespective of whether patients have received or used the product previously.
All prescribing to ensure patient has 2 devices.

03.04.03 Adrenaline / Epinephrine Jext® Adult: 300micrograms
Junior:150micrograms

N.B. Most cost-effective pen.

NOTE: Ensure that training is given to all patients, for all prescriptions, irrespective of whether patients have received or used the product previously.
All prescribing to ensure patient has 2 devices.
03.04.03 Adrenaline / epinephrine Emerade® 150micrograms for children between 15 and 30kg
300micrograms for children over 30kg and adults
500micrograms an option for adolescents and adults over 60kg (recommended dose 5 to 10 micrograms/ kg)
The Emerade device has a longer needle length and may be more suitable for patients with a thick sub-cutaneous fat layer.
NOTE: Ensure that training is given to all patients, for all prescriptions, irrespective of whether patients have received or used the product previously.
All prescribing to ensure patient has 2 devices.
03.04.03 Adrenaline / epinephrine 1 in 1,000  1 in 1000 1mL Injection
1 in 1000 5mL Injection
03.04.03 Adrenaline / epinephrine 1 in 1,000  1 in 1000 1mL Anaphylaxis Pre-filled syringe

Available in anaphylaxis box.
02.07.03 Adrenaline / Epinephrine 1 in 10,000 (dilute)  10mL Pre-Filled Syringe
10mL ampoule for Injection

For emergency resuscitation only
To be used in line with Resuscitation Council guidance.
03.04.03 Adrenaline / epinephrine 1 in 10,000 (dilute)  1 in 10,000 10mL Pre-filled syringe.

Available on crash trolley.

03.04.03 Adrenaline / epinephrine 1 in 10,000 (dilute)  1 in 10,000 1mL Injection
1 in 10,000 10mL Injection

Available on crash trolley.
14.04 Adsorbed Diphtheria [low dose], Tetanus and Inactivated Poliomyelitis  Revaxis® For children over 10 years and adults

In primary care as part of the routine national UK immunisation schedule
08.01.05 Afatinib Giotrif® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
20mg, 30mg, 40mg & 50mg Tablets

Approved in accordance with NICE TA310 for the treatment of metastatic non-small-cell lung cancer.

11.08.02 Aflibercept 40mg/1mL Eylea® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage. Funded by NHS England.

Restricted - prescribing by consultant Ophthalmologists in-line with NICE TA's below.
04.03.04 Agomelatine Valdoxan®

For initiation and ongoing prescribing by ELFT Specialist only.

05.05.01 Albendazole 400mg 

unlicensed unlicensed

For helminth infections. 

N.B. not routinely stocked

09.02.02.02 Albumin Solution 

Order from Haematology

08.01.05 Alectinib 150mg Alecsena®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Approved in accordance with NICE TA536.

08.02.03 Alemtuzumab Lemtrada® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA312 as a possible treatment for active relapsing-remitting multiple sclerosis

12mg/1.2mL Injection
30mg/1mL Injection
06.06.02 Alendronic Acid 

10mg & 70mg Tablets
1st Choice for osteoporosis

Not licensed for use in men

09.06.04 Alfacalcidol One-Alpha® 0.25microgram & 1microgram Capsules
2microgram/1mL Oral Liquid
09.06.04 Alfacalcidol  1microgram/0.5mL Injection
15.01.04.03 Alfentanil Rapifen® 1mg/2mL & 5mg/10mL Injection
5mg/1mL Injection - Restricted for ITU Only
07.04.01 Alfuzosin Hydrochloride  2.5mg Tablets
10mg Modified Release Tablets
03.04.01 Alimemazine 

For paediatric dermatology patients where no alternative is effective.

30mg/5mL - N.B. cost now > £250 per bottle
7.5mg/5mL - N.B. cost now > £150 per bottle

N.B. GP's will no longer prescribe this due to availability of alternatives and cost.

03.04.01 Alimemazine 10mg 

For paediatric dermatology patients where no alternative is effective.

N.B. GP's will no longer prescribe this due to availability of alternatives and cost.

02.12 Alirocumab 75mg/mL, 150mg/mL Praluent® FOR ALL PRESCRIBING - a completed and approved HIGH COST DRUG compliance form is required. Complete on Blueteq (link on front page).

Prescribing initiation and continuation by Consultant Chemical Pathologist only.

For treatment of primary hypercholesterolaemia (heterozygous familial and non-familial) and mixed dyslipidaemia in accordance with NICE TA393 (alirocumab).
13.05.01 Alitretinoin Toctino®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

10mg & 30mg Capsules

Approved in accordance with NICE TA177 for the treatment of severe chronic hand eczema. For more information click the link below.

Restricted - must be initiated by a consultant Dermatologist.

Must not be prescribed on FP10 prescriptions

10.01.04 Allopurinol 100mg , 300mg Zyloric® 1st Choice prophylaxis for gout
06.01.02.03 Alogliptin  1st choice DPP4-inhibitor

12.5mg, 25mg Film Coated Tablets

09.06.05 Alpha Tocopheryl Acetate 500mg /5mL 

To be prescribed for the licensed indication only: For the correction of Vitamin E deficiency occurring in malabsorption disorders ie. cystic fibrosis, chronic cholestasis and abetalipoproteinaemia.

04.01.02 Alprazolam 

For initiation by Mental Health specialist from ELFT only

07.04.05 Alprostadil Caverject®

Only prescribable on the NHS for erectile dysfunction if fulfil NHS SLS criteria (listed in part XVIIIB of the Drug Tariff).

For second-line use after failure of oral PDE5-inhibitors.

02.10.02 Alteplase 10mg, 20mg & 50mg Actilyse®

Restricted - Only to be prescribed under specialist supervision for PE, MI, post-stroke. Refer to trust guidelines and NICE TA52 and TA264.

Restricted: approved for use by respiratory consultants for severe empyema (unlicensed use) with iintrapleural dornase alfa. See attached protocol for criteria and further details.

04.09.01 Amantadine  100mg Capsules
Restricted Item 50mg/5mL Syrup - only to be prescribed for patients who cannot swallow capsules.
17 Amidotrizoates Gastrografin®
05.01.04 Amikacin  100mg/2mL & 500mg/2mL vial

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.
02.02.03 Amiloride Hydrochloride  5mg Tablets
5mg in 5mL Sugar-Free Liquid
03.01.03 Aminophylline Phyllocontin Continus® 225mg & 350mg MR Tablets

Most cost-effective.
03.01.03 Aminophylline IV   Dose using ideal body weight if obese

For IV to oral aminophylline or theophylline dose conversion, see attached UKMi Q&A

02.03.02 Amiodarone 

100mg & 200mg Tablets
L&D Hospital: If newly prescribing oral treatment, ensure loading regime is prescribed using ePMA protocol.

02.03.02 Amiodarone  150mg in 3mL Injection
300mg in 10mL Pre-filled syringe
04.02.01 Amisulpride  50mg, 200mg & 400mg Tablets
100mg/1mL oral solution
04.03.01 Amitriptyline  10mg, 25mg & 50mg Tablets
50mg/5mL Oral solution
04.07.03 Amitriptyline  10mg, 25mg & 50mg Tablets
50mg/5mL Oral Solution
02.06.02 Amlodipine  5mg & 10mg Tablets
05.01.01.03 Amoxicillin  250mg & 500mg Capsules
125mg/5mL & 250mg/5mL sugar free syrup
3g sugar free Sachets

Amoxicillin has good oral bioavailability. The switch from IV to oral amoxicillin should take place as soon as a patient’s clinical condition improves.
05.01.01.03 Amoxicillin  250mg & 500mg Injection

Amoxicillin has good oral bioavailability. The switch from IV to oral amoxicillin should take place as soon as a patient’s clinical condition improves.
05.02.03 Amphotericin (liposomal) 50mg AmBisome ® Restricted - Microbiology approval required.

09.01.04 Anagrelide 0.5mg Xagrid®

Restricted- prescribing by consultant Haematologists.

08.03.04.01 Anastrozole 1mg Arimidex®
05.02.04 Anidulafungin 

Restricted High Cost Drug - Microbiology approval required. 

11.04.02 Antazoline 0.5% with Xylometazoline 0.05% Otrivine-Antistin® For primary care this can be purchased OTC
13.08.01 Anthelios XL® 

N.B. Must write 'ACBS' on FP10 borderline substance.

May be prescribed for skin protection against ultraviolet radiation and/or visible light in abnormal cutaneous photosensitivity causing severe cutaneous reactions in genetic disorders (including xeroderma pigmentosum and porphyrias), severe photodermatoses (both idiopathic and acquired) and in those with increased risk of ultraviolet radiation causing severe adverse effects due to chronic disease (such as haematological malignancies), medical therapies and/or procedures

14.05.03 Anti-D (Rh0) Immunoglobulin  Approved in accordance with NICE TA156 for the treatment of pregnant women who are RhD negative and who are not known to be sensitised.
01.07.01 Anusol  Cream
Suppositories

N.B. in primary care these products can be purchased over the counter for self-care.
01.07.02 Anusol 

Ointment and suppositories

L&D hospital only.

Primary care: Patients advised to purchase over the counter

01.07.02 Anusol-HC 

Ointment and suppositories

02.08.02 Apixaban 2.5mg & 5mg Eliquis®

Refer to NICE TA275/TA341 AND anti-coagulation guidelines.

N.B. not advised to prescribe at extremes of bodyweight (120kg).

Compared to apixaban exposure in subjects with body weight of 65 to 85 kg, body weight > 120 kg was associated with approximately 30% lower exposure and body weight < 50 kg was associated with approximately 30% higher exposure. (from manufacturers SPC).

N.B. apixaban has not been studied in patients with prosthetic heart valves and its use is not recommended in these patients (see MHRA DSU Oct 18 link under rivaroxaban).

04.09.01 Apomorphine  

Dacepton and APO-go brands

Dacepton ®

30mg/3mL pen cartridge

100mg/20mL solution for infusion

APO-go ®

30mg in 3ml pen

50mg/10mL prefilled syringe solution for infusion

  • initiation by consultant specialising in Parkinson's only inline with JPC shared care guideline (shared care guidline currently being updated)


11.08.02 Apraclonidine 0.5% Iopidine®
11.08.02 Apraclonidine 1% Iopidine®
10.01.03 Apremilast Otezla® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Specialist consultant prescribing according to NICE TA433.
10mg, 20mg, 30mg tablets.
13.05.03 Apremilast Otezla® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Specialist consultant prescribing according to NICE TA419.

10mg, 20mg, 30mg tablets.
04.06 Aprepitant Emend® Restricted - Chemotherapy use only

3 day pack - 125mg prior to chemotherapy followed by 80mg once daily for 2 days
A5.03.03 Aquacel Ag Plus 

Ribbon only in this brand, 2 x 45cm. For silver dressings prescribe Kerracontact Ag.

Refer to Wound Management Formulary or TVN for appropriate use.

01.06.03 Arachis Oil 

Now £57 per enema. Not to be used first-line.

06.05.02 Argipressin (Synthetic Vasopressin) 

20Unit/1mL Injection
Only Stocked in ITU for septic shock or organ donation
N.B. £101 per 1 ampoule

04.02.01 Aripiprazole  5mg, 10mg, 15mg & 30mg Tablets
10mg & 15mg Orodispersible Tablets
1mg/1mL Solution

Restricted - to be prescribed in accordance with NICE TA213 and 292.
04.02.02 Aripiprazole Abilify Maintena®

Specialist initiation and continuation

04.02.01 Aripiprazole 7.5mg, 9.75mg  Only for continuation of treatment whist inpatient at Luton & Dunstable Hospital.
Initiation by Psychiatrist (Mental Health Trust) only, in line with NICE TA213 and 292 (as above).


08.01.05 Arsenic Trioxide Trisenox®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted - prescribing by Oncologists according to NICE TA526

05.04.01 Artemether with lumefantrine 20mg/ 120mg Riamet® First choice in uncomplicated FALCIPARUM malaria.

N.B. Complex dosing regime. Use BNF / BNFC or SPC for dose.
Prescribe on ePMA using stat timed doses.

To increase absorption, tablets should be taken with food or a milky drink. If patients are unable to tolerate food, tablets should be administered, but the systemic exposure may be reduced. Patients who vomit within 1 hour of taking the medication should repeat the dose.
For administration to small children and infants, tablets may be crushed.
05.04.01 Artesunate  unlicensedunlicensed 60mg injection.
First choice for the treatment of severe or complicated FALCIPARUM malaria.

This is stocked in the emergency drug cupboard (contact 555 out of hours).

09.06.03 Ascorbic Acid 

50mg, 100mg, 200mg & 500mg Tablets

Primary Care: patients advised to purchase over the counter

04.07.01 Aspirin  300mg Dispersible Tablets
02.09 Aspirin (antiplatelet)  75mg & 300mg dispersible tablet


Red Traffic Light  150mg & 300mg Suppositories unlicensedunlicensed


05.03.01 Atazanavir Reyataz® 200mg & 300mg Capsules

Restricted - must be prescribed by HIV consultants only
05.03.01 Atazanavir & cobicistat Evotaz® Atazanavir 300mg / cobicistat 150mg Tablets
Restricted - must be prescribed by HIV Consultants
02.04 Atenolol  5mg in 10mL Injection
02.04 Atenolol  25mg, 50mg & 100mg Tablets
25mg in 5mL Sugar-Free Solution
08.01.05 Atezolizumab 1200mg Tecentriq®

Funding approval required.

Approved, in accordance with the Cancer Drugs Fund, for the first line treatment of locally advanced or metastatic urothelial cancer in patients who are ineligible for cisplatin-based chemotherapy. NICE TA492.

Funding approval required for use in line with the other NICE TA's below.

 

04.04 Atomoxetine 

10mg & 25mg Capsules
Only to be initiated by specialist in ADHD according to NICE TA98.

Follow shared care guidance below.

02.12 Atorvastatin  10mg, 20mg, 40mg & 80mg Tablets
07.01.03 Atosiban 

6.75mg/0.9mL Injection
37.5mg/5mL Injection

15.01.05 Atracurium Besilate  25mg/2.5mL, 50mg/5mL & 250mg/25mL Injection
15.01.03 Atropine   600microgram/1mL Injection
3mg/10mL Pre-filled Syringe
11.05 Atropine 1%  
18 Atropine 600micrograms/1mL  Toxicity with organophosphates and carbamates
Bradycardia
11.05 Atropine Sulphate 1% single use Minims® Atropine Sulphate Preservative-free
08.01.05 Avelumab 20mg/mL Bavencio®

Cancer Drug Funded in accordance with criteria in NICE TA517.

07.04.05 Aviptadil / phentolamine 25mcg / 2mg Invicorp®

Only prescribable on the NHS for erectile dysfunction if fulfil NHS SLS criteria (listed in part XVIIIB of the Drug Tariff).

For second-line use after failure of oral PDE5-inhibitors.

08.01.05 Axicabtagene ciloleucel  Yescarta®

Cancer Drug Funded in accordance with criteria in NICE TA559.

08.01.05 Axitinib Inlyta® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted to prescribing in accordance with NICE TA333.
08.01.03 Azacitidine Vidaza® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
unlicensedunlicensed pre-filled syringes 57.5mg/2.3mL, 60mg/2.4mL, 62.5mg/2.5mL, 65mg/2.6mL, 67.5mg/2.7mL, 70mg/2.8mL, 75mg/3mL & 80mg/3.2mL Subcutaneous Injection

Approved in accordance with NICE TA218 for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukaemia and acute myeloid leukaemia
01.05.03 Azathioprine 

25mg, 50mg tablets

Shared Care Guidelines for Inflammatory Bowel Disease

08.02.01 Azathioprine  25mg & 50mg Tablets
unlicensedunlicensed 50mg/5mL Suspension

10.01.03 Azathioprine 

25mg & 50mg Tablets

For Rheumatology - see JPC shared care guidelines.

13.05.03 Azathioprine  See section 8.2.1
10.01.03 Azathioprine 50mg/5mL 

unlicensedunlicensed
For paediatric patients or patients with swallowing difficulties.

 

For Rheumatology - see JPC shared care guidelines.

13.06.01 Azelaic Acid 20% Skinoren®
12.02.01 Azelastine and fluticasone Dymista

Fluticasone propionate 50microgram / azelastine 137micrograms per dose nasal spray.

Restricted  for 2nd-line use after topical corticosteroids.

05.01.05 Azithromycin  250mg Tablets
200mg/5mL Suspension

Consultant recommendation only.
05.01.02.03 Aztreonam 1g  Azactam® Restricted - Microbiology Approval required.

N.B. Not always available - check with Pharmacy before prescribing.
10.02.02 Baclofen  10mg Tablets
5mg/5mL Oral Liquid
First choice skeletal muscle relaxant
10.01.03 Baricitinib 2mg, 4mg Olumiant® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Must be prescribed by a Rheumatology consultant in accordance with NICE TA466.
08.02.04 BCG bladder instillation OncoTICE®

Restricted - prescribing by consultant urologists only

14.04 BCG vaccine diagnostic agent (Tuberculin Purified Protein Derivative (PPD)) 
14.04 BCG vaccine Intradermal 
06.01.01.03 BD AutoShield Duo ® 

 

5mm/30 gauge

For prescribing in primary care only when insulin is being administered by a carer.

03.02 Beclometasone Qvar® Qvar and Clenil Modulite are NOT interchangeable and should be prescribed by brand name. Qvar has extra-fine particles and is approximately twice as potent as Clenil Modulite

50micrograms & 100micrograms per metered inhalation (MDI)
100micrograms per metered dose - Autohaler

03.02 Beclometasone and formoterol Fostair® Corticosteroid and long-acting beta-2 agonist (ICS/LABA).

Fostair has extra-fine particles and is more potent than traditional beclometasone dipropionate CFC inhalers.

Beclometasone 100microgram/Formoterol 6microgram per pressurized metered dose



03.02 Beclometasone and formoterol Fostair NEXThaler® Corticosteroid and long-acting beta agonist (ICS/LABA).

Fostair has extra-fine particles and is more potent than traditional beclometasone dipropionate CFC inhalers.

Beclometasone 100microgram/Formoterol 6microgram per metered dose
03.02 Beclometasone Dipropionate Easyhaler Beclometsone® 200microgram per metered dose dry powder inhaler Low carbon option
03.02 Beclometasone Dipropionate Clenil Modulite® 50microgram, 100microgram, 200microgram & 250microgram per metered dose
12.02.01 Beclometasone Dipropionate 50micrograms per metered dose  1st choice steroid spray
In primary care adults may purchase this over the counter

03.01.04 beclomethasone/formoterol/ glycopyrronium 87 micrograms/5 micrograms/9 micrograms Trimbow®

Approved by JPC as a  as a joint 1st-line triple therapy option (ICS / LAMA/ LABA) for the treatment of COPD. 

Each delivered dose (the dose leaving the mouthpiece) contains 87 micrograms of beclometasone dipropionate, 5 micrograms of formoterol fumarate dihydrate and 9 micrograms of glycopyrronium (as 11 micrograms glycopyrronium bromide).

Each metered dose (the dose leaving the valve) contains 100 micrograms of beclometasone dipropionate, 6 micrograms of formoterol fumarate dihydrate and 10 micrograms of glycopyrronium (as 12.5 micrograms glycopyrronium bromide).

10.01.05 Belimumab Benlysta® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Rheumatology consultant prescribing only, in accordance with NICE TA397.
08.01.01 Bendamustine  FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
25mg & 100mg Injection
unlicensedunlicensed 110mg - 240mg in 0.9% Sodium Chloride Infusion (500mL)

Restricted for the treatment of chronic lymphocytic leukaemia in accordance with NICE TA216 and for other indications using Cancer Drug Fund.

02.02.01 Bendroflumethiazide  2.5mg Tablets
04.02.01 Benperidol Anquil®

For intitation and prescribing by ELFT Specialists only

03.04.02 Benralizumab Fasenra®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA below.

13.09 Benzalkonium Chloride  Dermax®
05.01.01.01 Benzathine Benzylpenicillin 1.2megaunits, 2.4megaunits  unlicensedunlicensed. For the treatment of syphilis only. Follow most up-to-date BASHH guidelines, see link below:
13.06.01 Benzoyl Peroxide 5% 

Self-care in Primary Care.

More cost-effective to purchase than prescription charge.

13.06.01 Benzoyl Peroxide 5% with Clindamycin 1% Duac® Once Daily
12.03.01 Benzydamine 0.15% Difflam®
05.01.01.01 Benzylpenicillin   600mg & 1.2g Injection
04.06 Betahistine   8mg & 16mg Tablets
09.08.01 Betaine 
06.03.02 Betamethasone  4mg/1mL Injection
06.03.02 Betamethasone  500microgram Soluble Tablets

Restricted: for oral surgery patients only
13.04 Betamethasone (as Dipropionate) 0.05% with Salicylic Acid 3% Diprosalic®

Ointment and Scalp Application
 
Very Potent

13.04 Betamethasone (as Valerate) 0.025% Betnovate-RD®

Moderately Potent

13.04 Betamethasone (as Valerate) 0.1% Betnovate®

Potent

13.04 Betamethasone (as Valerate) 0.1% with Clioquinol Generic

Potent

13.04 Betamethasone (as Valerate) 0.1% with Fucidic Acid 2% Fucibet®

Potent

12.01.01 Betamethasone 0.1% 

eye/ear/nose drops

12.02.01 Betamethasone 0.1% nasal drops 
12.03.01 Betamethasone 500mcg 

For use as a mouthwash

11.04.01 Betamethasone eye drops 0.1% 

Eye Ointment
Drops for eye, ear, nose

11.04.01 Betamethasone with Neomycin 

Betamethasone 0.1%/Neomycin 0.5% Eye Drops

12.01.01 Betamethasone with Neomycin Betnesol N®

0.1% Betamethasone/ 0.5% Neomycin Sulphate eye/ear/nose drops

11.06 Betaxolol Betoptic® 0.5% Eye Drops
11.08.02 Bevacizumab intravitreal 1.25mg in 0.05mL Avastin®

Approved for the treatment of retinopathy of prematurity.

02.12 Bezafibrate  200mg Tablets
400mg Modified Release Tablets
08.03.04.02 Bicalutamide 

50mg & 150mg Tablets

11.06 Bimatoprost  2nd Choice of prostaglandin analogue eye drops
100microgram/mL Eye Drops
08.01.05 Binimetinib 15mg Mektovi®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved for use with encorafenib in accordance with the NICE TA below.

06.01.01.02 Biphasic Insulin Aspart  NovoMix® 30 (3mL cartridge, 3mL FlexPen prefilled disposable injection device)
06.01.01.02 Biphasic Insulin Lispro  Humalog® Mix25 10mL vial
Humalog® Mix25 and Mix50 (3mL cartridge, 3mL KwikPen prefilled disposable injection device)
06.01.01.02 Biphasic Isophane Insulin (HUMAN)  Humulin M3® (10mL vial, 3mL cartridge)
Insuman® Comb 15, 25 and 50 (multiple devices)

01.06.02 Bisacodyl  5mg, 10mg suppositories
10mg enteric coated tablets
02.04 Bisoprolol  1.25mg, 2.5mg, 5mg, 7.5mg & 10mg Tablets
02.08.01 Bivalirudin 250mg Angiox® Restricted - prescribing by Cardiologists only for patients intolerant to first line treatment options for ACS STEMI and in accordance with NICE TA 230 Bivalirudin for the treatment of ST-segment-elevation myocardial infarction.
08.01.02 Bleomycin  unlicensedunlicensed 7000Units in Sodium Chloride 0.9% Injection
unlicensedunlicensed 14000Units, 16000Units, 17000Units, 18000Units, 19000Units, 20000Units, 21000Units & 22000Units in 0.9% Sodium Chloride Infusion (100mL)

Restricted - must seek authorisation from a consultant before prescribing
08.02 Blinatumomab Blincyto®

Approved in accordance with NICE TA450 and the Cancer Drugs Fund for previously treated Philadelphia-chromosome-negative acute lymphoblastic leukaemia in adults.

Approved in a accordance with NICE TA589 for treating acute lymphoblastic leukaemia in remission with minimal residual disease activity.

06.01.06 Blood and Ketone Meters (Dual Meters) 

Agreed formulary blood glucose meter choices (and corresponding strips):

GlucoMen Areo 2K

06.01.06 Blood Glucose Testing Meters and strips 

Agreed formulary blood glucose meter choices (and corresponding strips):

Finetest Lite

GlucoRX Nexus

Mylife Pura

SD Codefree

TEE2+

WaveSense JAZZ

BCCG preferred formulary choices:

Mylife Pura

TEE2+

LCCG preferred formulary choices:

Finetest Lite Smart

Palmdoc

08.01.05 Bortezomib Velcade®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
3.5mg Injection
unlicensedunlicensed 1.25mg/0.5mL, 1.5mg/0.6mL, 1.75mg/0.7mL, 1.8mg/0.72mL, 2mg/0.8mL, 2.2mg/0.88mL, 2.25mg/0.9mL & 2.5mg/1mL Subcutaneous Injection
unlicensedunlicensed 1.5mg - 2.7mg in 0.9% Sodium Chloride Injection

Approved in accordance with NICE TAs outlined below.

Restricted - must only be prescribed by staff with specialist training in Oncology or Haematology

08.01.05 Bosutinib Bosulif® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted - prescribing by Oncologists according to NICE TA401.
01.07.04 Botulinum toxin type A Botox FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

100 units/vial injection

Restriction - for consultant initiation only
Must be prescribed by both GENERIC and BRAND name
04.07.04.02 Botulinum Toxin Type A botox® Restricted - to be initiated under Consultant authorization and in accordance with NICE TA260

Must be prescribed by brand name

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link on Netformulary homepage.
04.09.03 Botulinum Toxin Type A Xeomin®

FOR ALL PRESCRIBING - Blueteq or High Cost Drug Form required - see link from Formulary Homepage.

Restricted prescribing in accordance with the following NICE TA:

13.12 Botulinum toxin type A  

Hospital only prescribing as per local CCG guideline

Blueteq funding request required

04.09.03 Botulinum Toxin Type A 100 units Botox ® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restriction - for consultant initiation only
Must be prescribed by both GENERIC and BRAND name
04.09.03 Botulinum Toxin Type A 300units, 500units Dysport® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restriction - for consultant initiation only
Must be prescribed by both GENERIC and BRAND name
14.04 Botulism antitoxin 

Bedford hospital is a holding centre

08.01.05 Brentuximab vedotin 50mg Adcetris® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA446 & TA478.
08.01.05 Brentuxumab Adcetris®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted - prescribing by Oncologists according to NICE TA524.

08.01.05 Brigatinib Alunbrig®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with the NICE TA below.

11.06 Brinzolamide  10mg/1mL Eye Drops
04.08.01 Brivaracetam Briviact® 10mg,25mg,50mg,75mg,100mg film-coated tablets
10mg/mL oral solution
Restricted to patients who cannot have levetiracetam.
13.05.03 Brodalumab 210mg Kyntheum®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - for consultant dermatologist prescribing in line with NICE TA511.

04.09.01 Bromocriptine  5mg & 10mg Capsule
Consultant initiation. Risk of fibrotic reactions so careful monitoring required.
06.07.01 Bromocriptine 

2.5mg Tablets

01.05.02 Budesonide  Licensed for Crohn's disease.
3mg gastro-resistant capsules (Budenofalk)
3mg controlled release capsules (Entocort CR)
9mg gastro-resistant granules (Budenofalk sachets)
01.05.02 Budesonide Cortiment MMX®

9mg prolonged-release tablets

Restricted to prescribing by a gastroenterology specialist for ulcerative colitis patients who are unsuitable for oral prednisolone.

Hospital-only. Prescribe whole course (up to max. 8 weeks).

03.02 Budesonide Pulmicort Turbohaler®

100microgram, 200microgram & 400microgram per metered dose.

03.02 Budesonide Pulmicort Respules® 0.5mg & 1mg in 2mL Nebules
12.02.01 Budesonide 64micrograms per metered dose 
03.02 Budesonide and formoterol Symbicort®

Corticosteroid and long acting beta agonist (ICS/LABA).

100microgram/6microgram per metered dose
200microgram/6microgram per metered dose
400microgram/12microgram per metered dose

03.02 Budesonide and formoterol DuoResp Spiromax® Budesonide 160microgram / formoterol 4.5microgram: equivalent to a metered dose of 200microgram budesonide / 6microgram formoterol.

Budesonide 320microgram / formoterol 9microgram: equivalent to a metered dose of 400microgram budesonide / 12microgram formoterol.

N.B. Most cost-effective LABA + ICS
03.02 Budesonide and formoterol Symbicort®

Corticosteroid and long acting beta agonist (ICS/LABA).

200 microgram/6 microgram per metered dose

02.02.02 Bumetanide  1mg & 5mg Tablets
15.02 Bupivacaine Hydrochloride  0.25% & 0.5% Injection
15.02 Bupivacaine Hydrochloride with Glucose Marcain Heavy®
15.02 Bupivacaine With Adrenaline   Bupivacaine 0.25%/Adrenaline 1 in 200,000 Injection
Bupivacaine 0.5%/Adrenaline 1 in 200,000 Injection
04.10.03 Buprenorphine 2mg, 8mg Espranor® Restricted - prescribing by specialist dependency services according to NICE TA114. N.B. Must ensure the correct formulation is prescribed as these are not interchangeable with the sublingual tablets. L&D:Listed on JAC as 'buprenorphine (Espranor) orodispersible tablets'
04.10.03 Buprenorphine 2mg, 8mg 

Restricted - prescribing by specialist dependency services according to NICE TA114.

Prescribe generically.

04.10.03 Buprenorphine / Naloxone 

Buprenorphine 2mg / naloxone 500micrograms
Buprenorphine 8mg / naloxone 2mg
Restricted - prescribing by specialist dependency services according to NICE TA114.

Prescribe generically

04.07.02 Buprenorphine 200microgram, 400microgram 

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and countersigned in order to fulfill the legal requirements of controlled drug prescriptions. e.g. Please supply Five (5) tablets (signed).

04.07.02 Buprenorphine 35, 52.5, 70 microgram  Releasing 35micrograms per hour, 52.5micrograms per hour or 70micrograms per hour over 96 hours.For convenience of use, this can be changed twice a week at regular intervals.

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfil the legal requirements of controlled drug prescriptions. e.g. Please supply Four (4) patches (signed).
N.B. pack size is 4 patches.
04.07.02 Buprenorphine 5, 10 microgram BuTrans® patch Releasing 5micrograms/ hour over 7 days OR
Releasing 10micrograms/ hour over 7 days

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfil the legal requirements of controlled drug prescriptions. e.g. Please supply two (2) patches (signed).
04.10.02 Bupropion Hydrochloride Zyban® For use in accordance with the Luton & Dunstable Hospital's Trust Guidelines.

Restricted - to be prescribed on the recommendation of a smoking cessation specialist.
08.03.04.02 Buserelin 

5.5mg/5.5mL Injection

06.07.02 Buserelin 1mg/1mL Suprecur®

For the fertility clinic only

04.01.02 Buspirone Hydrochloride  Restricted - initiation by Psychiatric team only.

5mg Tablets

08.01.01 Busulfan  2mg Tablets

03.04.03 C1 Esterase Inhibitor Berinert®

High Cost Drug.

Restricted - prescribing by consultants for:
1. Acute life threatening attacks of hereditary angioedema
2. Short-term prophylaxis of hereditary angioedema before dental, medical, or surgical procedures

08.01.05 Cabazitaxel Jevtana® FOR ALL PRESCRIBING - a completed and approved HIGH COST DRUG compliance form, via BLUETEQ, is required.
Restricted - prescribing by Consultant Oncologists in line with NICE TA391
06.07.01 Cabergoline  500microgram Tablets
08.01.05 Cabozantinib Cabometyx®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved according to NICE TA's below.

08.01.05 Cabozantinib Cometriq®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved according to NICE TA516.

03.05.01 Caffeine Citrate 

Injection 10mg/1mL

Oral solution 10mg/1mL

For neonatal unit only.

13.05.02 Calcipotriol 50 micrograms/ml 
13.05.02 Calcipotriol 50microgram/g 
13.05.02 Calcipotriol 50micrograms/g with Betamethasone 0.05% Enstilar®
06.06.01 Calcitonin (salmon) / Salcatonin  50Unit/1mL , 100Unit/1mL & 400Unit/2mL Injection
09.06.04 Calcitriol 250nanograms, 500nanograms 

For renal patients only.

13.05.02 Calcitriol 3micrograms/g Silkis®
18 Calcium chloride 10% injection, prefilled syringe Calcium 27.3mg (680micromol/mL)

Calcium channel blocker toxicity
Systemic effects of hydrofluoric acid
09.05.02.02 Calcium Acetate 

For renal patients only.

Two brands available:

Phosex: each tablet contains calcium Acetate 1000 mg (calcium acetate anhydrous 986.36 mg) equivalent to 250 mg calcium.

Renacet: 

475mg: each tablet contains 475 mg calcium acetate (anhydrous) equivalent to 120.25 mg calcium.

950mg: each tablet contains 950 mg calcium acetate (anhydrous) equivalent to 240.50 mg calcium.

09.05.01.01 Calcium Carbonate Cacit®

Calcium carbonate 1.25g (500mg / 12.5mmol calcium) per tablet.

For paediatric doses: dissolve one tablet of Cacit in 24mL of water to provide an orange flavoured solution containing 12.5mmol calcium in 25mL from which the required dose can be withdrawn. 

09.05.01.01 Calcium Carbonate 

Calcium carbonate 1.5g (600mg calcium) per tablet.

Prescribe generically. Current brand is Adcal  but this may change.





09.05.01.01 Calcium carbonate & calcium lactate gluconate Sandocal-1000® Each tablet contains 1g (25mmol)calcium .
09.05.01.01 Calcium Chloride 10%  10mL ampoule containing 10mmol calcium.


09.05.01.01 Calcium Chloride 10%  Calcium 273mg / 6.8mmol
08.01 Calcium Folinate  15mg Tablets
30mg/10mL Injection
100mg/10mL & 300mg/30mL Injection Solution

18 Calcium folinate 300mg/30mL Leucovorin®

toxicity with methotrexate
toxicity with methanol and formic acid

L&D - Kept in EDC (Pharmacy emergency drug cupboard)

BHT - Kept in Primrose or via Pharmacy (Oncall Pharmacist via switchboard out of hours)

18 Calcium gluconate 2.5% 

Prevention of transdermal adsorption of hydrofluoric acid

L&D - Kept in ED antidote cupboard.

BHT - Kept in Accident and Emergency

09.05.01.01 Calcium Gluconate 10%  Calcium 89mg / 2.23mmol.
18 Calcium gluconate 10%  Local infiltration for hydrofluoric acid
06.01.02.03 Canagliflozin  100mg Tablets
Approved in accordance with NICE TA315 or TA390 for the treatment of type 2 diabetes in adults.

02.05.05.02 Candesartan  2mg, 4mg, 8mg & 16mg Tablets
04.08.01 Cannabidiol Epidyolex®

No GP Prescribing

For use in accordance with the following NICE TAs only

08.01.03 Capecitabine  150mg & 500mg Tablets

Approved in accordance with NICE TA61, TA100 and TA191.

04.07.03 Capsaicin 0.075% Axsain®

For neuropathic pain.

02.05.05.01 Captopril 

12.5mg & 50mg Tablets

No new initiations - for continuing treatment only.

02.05.05.01 Captopril  5mg in 5mL Oral solution
25mg in 5mL Oral Solution
Restricted to paediatric use only.
(>£100 per 100mL bottle).
For adults, tablets will disperse in water over 1 to 5 minutes.
04.02.03 Carbamazepine 

Requires specialist initiation by mental health team for treatment of bipolar disorder.

04.07.03 Carbamazepine  100mg & 200mg Tablets
125mg & 250mg Suppositories
200mg & 400mg Sustained Release Tablets
100mg/5mL Suspension

Suppositories of 125 mg may be considered to be approximately equivalent in therapeutic effect to tablets of 100 mg but final adjustment should always depend on clinical response (plasma concentration monitoring recommended).
04.08.01 Carbamazepine 

100mg, 200mg Tablets
200mg & 400mg Sustained Release Tablets
100mg/5mL Suspension

WARNING: Prescribe by brand to ensure patient is maintained on a specific manufacturer's product.

L&D hospital: Tegretol is the brand stocked which most patients are on. Other brands can be ordered if needed.

04.08.01 Carbamazepine 125mg, 250mg 

Where oral administration not possible.
When switching from oral formulations to suppositories the dosage should be increased by approximately 25% (the 125 and 250mg suppositories correspond to 100 and 200mg tablets respectively).
Where Suppositories are used the maximum daily dose is limited to 1000mg (250mg qid at 6 hour intervals).
N.B. Cost increase to £144 for 5 x 125mg, £168 x 5 x 250mg
Only prescribe for short-term use in epilepsy. Consider enteral tube administration if for longer than 2-3 days.

06.02.02 Carbimazole  5mg & 20mg Tablets
03.07 Carbocisteine  375mg Capsules
250mg in 5mL Syrup
11.08.01 Carbomer 980  
08.01.05 Carboplatin  unlicensedunlicensed 75mg - 800mg in 5% Glucose Infusion (500mL)

Restricted - must only be prescribed by staff with specialist training in Oncology or Haematology
07.01.01 Carboprost  250microgram/1mL Injection
08.01.05 Carfilzomib 10mg. 30mg, 60mg Kyprolis® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in line with NICE TA457 for previously treated multiple myeloma.
09.08.01 Carglumic Acid 200mg Carbaglu®

For paediatric patients.

Kept in the L&D pharmacy EDC for use before patient transfer to a specialist hospital.

11.08.01 Carmellose Sodium  0.5% & 1% Eye Drops single use, preservative-free
08.01.01 Carmustine Gliadel® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
For use according to NICE TA121

Currently not commissioned at the L&D
02.04 Carvedilol  3.125mg, 6.25mg, 12.5mg & 25mg Tablets
05.02.04 Caspofungin 50mg, 70mg  Restricted High Cost Drug - Microbiology approval required.

05.01.02 Cefalexin  250mg & 500mg Capsules
125mg/5mL & 250mg/5mL Suspension

Restricted to Paediatrics and Obs & Gynae in-patients.
05.01.02 Cefepime 1g, 2g  Restricted to recommendation by Consultant Microbiologist only. Last line choice where sensitivity is known in severe uncomplicated pyelonephritis or certain respiratory tract infections.
05.01.02 Cefotaxime  500mg, 1g & 2g Injection

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.

If ceftriaxone is unavailable, prescribe cefotaxime 2g QDS for adult patients with suspected meningitis.
05.01.02 Ceftazidime  500mg, 1g & 2g Injection

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.
05.01.02 Ceftazidime 2g/ avibactam 0.5g Zavicefta® Microbiology recommendation only.
For multi-drug resistant infections where no alternative antimicrobial agent is likely to be effective.
05.01.02 Ceftolozane & tazobactam Zerbaxa®

Only on the recommendation of a consultant Microbioogist for multi-drug resistant infections where there are no alternative options.

05.01.02 Ceftriaxone  250mg, 1g & 2g Injection

Restricted to paediatrics, Luton Sexual Health clinic and adult patients with suspected meningitis.

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.
05.01.02 Cefuroxime  250mg, 750mg & 1.5g Injection

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.
11.03.01 Cefuroxime  

unlicensedunlicensed. 5% eye drops, preservative-free.

14 day expiry once defrosted (takes about 30 mins).

10.01.01 Celecoxib  100mg & 200mg Capsules

Restricted - must only be prescribed by Consultant Rheumatologists
08.01.05 Cemiplimab  Libtayo®

FOR ALL PRESCRIBING - Blueteq or High Cost Drug Form required - see link from Formulary homepage.

Restricted to prescribing in accordance with the following NICE TA (funded by the Cancer Drugs Fund):-

 

16.01 Cerament G 5mL, 10mL 

Bone void filler containing gentamicin.

Restricted to prescribing (or advised) by Ms Currall for managing patients with chronic osteomyelitis who also require debridement.

16.01 Cerament V 10mL 

Bone void filler containing vancomycin.

Restricted to prescribing (or advised) by Ms Currall for managing patients with chronic osteomyelitis who also require debridement.

08.01.05 Ceritinib Zykadia

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted - for use by Oncologists in line with NICE TA395 and TA500.

13.05.03 Certolizumab pegol 200 mg Injection Cimzia® Pre-filled Pen or Pre-filled Syringe

FOR ALL PRESCRIBING - Blueteq or High Cost Drug Form required - see link from Formulary Homepage

RESTRICTED for Consultant Dermatologist prescribing in line with the following NICE TA(s):

10.01.03 Certolizumab Pegol 200mg Cimzia® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Must be prescribed by a Rheumatology consultant in accordance with NICE TA375, TA383 or TA445.



03.04.01 Cetirizine 

10mg Tablets - Available to purchase over the counter
5mg in 5mL Solution - Available to purchase over the counter

13.02.01 Cetraben® 

Cream, ointment or lotion 

08.01.05 Cetuximab Erbitux® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
100mg/20mL & 500mg/100mL Injection
450mg - 1050mg in 0.9% Sodium Chloride Infusion (250mL)

Approved in accordance with NICE TA242, TA118, TA439 & TA473.

12.03.01 Cetylpyridinium, Chlrocresol, Lidocaine Anbesol® Paediatrics (babies) only.

In Primary care - can be purchased over-the-counter.
04.01.01 Chloral Hydrate 500mg/5mL 

Less suitable for prescribing. Prescribe only where there is no alternative.

Avoid prolonged use and abrupt withdrawal thereafter.

Standard strength liquid is 500mg/5ml as per RCPCH/NPPG guidance http://nppg.org.uk/position-statements/

08.01.01 Chlorambucil  2mg Tablets

11.03.01 Chloramphenicol  0.5% Eye Drops
1% Eye Ointment
05.01.07 Chloramphenicol 1g  Restricted - Microbiology Approval required.
Reserved for life-threatening infections.
05.01.07 Chloramphenicol 250mg  Restricted - Microbiology Approval required.
Reserved for life-threatening infections.
N.B. cost > £400 per box of 60.
04.01.02 Chlordiazepoxide 

5mg & 10mg Capsules
L&D - For alcohol detoxification a maximum of 3 doses can be supplied on a TTA.
BHT - As per the Trust Alcohol Detoxification Guideline, chlordiazepoxide must not be supplied to the patient on discharge 

11.03.01 Chlorhexidine  unlicensedunlicensed 0.02% Eye Drops
13.11.02 Chlorhexidine 0.015% with Cetrimide 0.15% Tisept® 25mL & 100mL Sachets
13.11.02 Chlorhexidine 4% solution Hibiscrub®
12.02.03 Chlorhexidine Hydrochloride with Neomycin Suphate  Naseptin®

Chlorhexidine 0.1%/Neomycin Sulphate 0.5%

Should not be used in patients with peanut allergies

MRSA protocol 2 (if Octenisan gel and mupirocin are unavailable):

Octenisan antimicrobial wash lotion 1 application OM for 10 doses

Naseptin cream 1 application QDS for 10 days

12.03.04 Chlorhexidine mouthwash 0.2% 
13.11.02 Chlorhexidine Obstetric  Cream
05.04.01 Chloroquine phosphate 250mg (chloroquine base 155mg) Avloclor ® Not for malaria prophylaxis - private GP prescription needed.
05.04.01 Chloroquine Sulphate 68mg/5mL (chloroquine base 50mg/5mL) Nivaquine® Not for malaria prophylaxis - private GP prescription needed.
03.04.01 Chlorphenamine (Oral)  4mg Tablets - Available to purchase over the counter
2mg in 5mL Oral Solution

03.04.01 Chlorphenamine 10mg/ 1mL 
04.02.01 Chlorpromazine  50mg/2mL Injection
04.02.01 Chlorpromazine  25mg, 50mg & 100mg Tablets
25mg/5mL Syrup
100mg/5mL Syrup
04.06 Chlorpromazine Hydrochloride  25mg, 50mg & 100mg Tablets
100mg/5mL Syrup
04.06 Chlorpromazine Hydrochloride  50mg in 2mL Injection
12.03.01 Choline Salicylate 8.7%  Bonjela® Adult Available for patients aged 16 or older
In primary care may be purchased over the counter
06.05.01 Choriogonadotropin alfa 250mcg Ovitrelle®

For Fertility clinic only.

N.B. 250micrograms is equivalent to approximately 6500units

06.05.01 Chorionic Gonadotrophin 

unlicensed unlicensed

N.B. Pregnyl has now been discontinued.

Available as an unlicensed product in 3 strengths: 2000units, 1500units & 5000units.

08.02.02 Ciclosporin Neoral®

Capsules and liquid available

10.01.03 Ciclosporin 

All Products which contain ciclosporin must be prescribed by brand name due to differences in bioavailability.

Neoral brand stocked at the L&D.

To be initiated by a consultant rheumatologist.

13.05.03 Ciclosporin  See section 8.2.1
11.08.01 Ciclosporin 1mg/mL Ikervis ®

Restricted - initiation by consultant ophthalmologists in the corneal clinic for the treatment of severe keratitis in adult patients with dry eye disease that has not improved despite treatment with tear substitutes in accordance with NICE TA369.

08.02.02 Ciclosporin 50mg/1mL Sandimmun®


 Restricted - must seek authorisation from a consultant before prescribing

09.05.01.02 Cinacalcet 

30mg Film Coated Tablets
Restricted - must be prescribed by consultant Endocrinologist

Approved in accordance with NICE TA117 for the treatment of secondary hyperparathyroidism in patients with end-stage renal disease on maintenance dialysis therapy.

N.B. Shared Care Guideline currently under review

04.06 Cinnarizine 15mg 
05.01.12 Ciprofloxacin  250mg, 500mg & 750mg Tablets
250mg/5mL Suspension

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.

Oral bioavailability of ciprofloxacin is approximately 70%. For treatment of gram negative sepsis recommended IV dose is 400 mg 12 hourly. Food delays the rate but not the extent of absorption. Early switch to oral therapy is encouraged.
05.01.12 Ciprofloxacin  100mg/5mL, 200mg/100mL & 400mg/200mL IV Infusion

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.

Oral bioavailability of ciprofloxacin is approximately 70%. For treatment of gram negative sepsis recommended IV dose is 400 mg 12 hourly. Food delays the rate but not the extent of absorption. Early switch to oral therapy is encouraged.
11.03.01 Ciprofloxacin  0.3% Ophthalmic solution
12.01.01 Ciprofloxacin 2mg/mL Cetraxal®

For the treatment of acute otitis externa in adults and children older than 1 year with an intact tympanic membrane, caused by ciprofloxacin susceptible microorganisms.

Presented in single-dose 1mL containers.

15.01.05 Cisatracurium  20mg/10mL Injection
08.01.05 Cisplatin  unlicensedunlicensed 26mg - 160mg in 0.9% Sodium Chloride Infusion (1000mL)

Restricted - must only be prescribed by staff with specialist training in Oncology or Haematology
04.03.03 Citalopram  10mg, 20mg & 40mg Tablets
40mg/1mL Sugar-Free Oral Drops

Bioavailability of the oral drops is different to the tablets
8mg oral drops = 10mg tablet

Max 20mg in elderly patients due risk of QT prolongation - see MHRA warning below
08.01.03 Cladribine 

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

To be prescribed by specialist in line with NICE TA616.

05.01.05 Clarithromycin 

250mg & 500mg Tablets
125mg/5mL Suspension
250mg/5mL Suspension

Good bioavailability.

05.01.05 Clarithromycin 500mg   Can cause injection site inflammation, tenderness, phlebitis and pain. Must be given via a large peripheral vein over at least 60 minutes diluted to 500mg in 250mL.

Switch to oral preparation as soon as possible since oral bioavailability is excellent (about 100%).
05.01.06 Clindamycin  300mg/2mL & 600mg/4mL Injection

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.

Caution in prescribing for any patient over 65 years due to increased risk of Clostridium difficile associated diarrhoea.
Oral bioavailability is excellent (>90%), therefore oral route recommended where possible.
07.02.02 Clindamycin  2% Vaginal Cream (40g with 7 applicators)
13.06.01 Clindamycin 1% Dalacin T®
05.01.06 Clindamycin 150mg   Oral bioavailability is excellent (>90%), therefore oral route recommended where possible.

Caution in prescribing for any patient over 65 years due to increased risk of Clostridium difficile associated diarrhoea.

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.
05.01.06 Clindamycin Palmitate 75mg/5mL   unlicensedunlicensed.

Restricted to paediatric patients or those with swallowing difficulties.

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.

Caution in prescribing for any patient over 65 years due to increased risk of Clostridium difficile associated diarrhoea.



13.06.01 Clindamycin/ tretinoin  Treclin®
04.08.01 Clobazam  10mg Tablets
04.08.01 Clobazam 5mg/ 5mL  For paediatric patients.
For enteral tube administration, tablets will disperse in 1 to 5 minutes.
13.04 Clobetasol propionate Etrivex®

Very potent

13.04 Clobetasol Propionate 0.05% Dermovate®

Very Potent

13.04 Clobetasol Propionate with neomycin and nystatin Dermovate-NN®

Very potent

13.04 Clobetasone Butyrate 0.05% Eumovate®®

Moderately Potent

 

13.04 Clobetasone butyrate with nystatin & oxytetracycline Trimovate®

Moderately Potent

Now available again

06.05.01 Clomifene Citrate 50mg 
04.03.01 Clomipramine 

10mg, 25mg & 50mg Capsules

04.08.01 Clonazepam 

500microgram & 2mg Tablets
2mg/5mL Oral Solution

02.05.02 Clonidine  0.15mg in 1mL injection
02.05.02 Clonidine  100microgram Tablets


04.07.04.02 Clonidine  25microgram Tablets
02.09 Clopidogrel 75mg  
07.02.02 Clotrimazole 

100mg & 500mg Pessaries
1% Cream

In pregnancy 100mg at night for six nights

13.10.02 Clotrimazole 1% 
12.01.01 Clotrimazole 1% Solution 
04.02.01 Clozapine Clozaril® Can only be prescribed by consultant Psychiatrist.

Supply of medication must be obtained from patient wherever possible - no stock kept at L&D Pharmacy. Must be dispensed by Mental Health Trust.

Prescriptions must include proprietary name.
04.02.01 Clozapine Denzapine® Can only be prescribed by consultant Psychiatrist.

Supply of medication must be obtained from patient wherever possible - no stock kept at L&D Pharmacy. Must be dispensed by Mental Health Trust.

Prescriptions must include proprietary name.
13.05.02 Coal tar 5% Exorex®

 Self-care in Primary care (purchase OTC).

13.05.02 Coal tar with salicyclic acid & prescipitated sulfur 

Cocois or Sebco brands.

Self-care in Primary care (purchase OTC).

13.09 Coal tar, coconut oil & salicylic acid Capasal®

Can be purchased OTC - self-care in Primary care.

02.02.04 Co-amilofruse  2.5/20mg Tablets
5/40mg Tablets
05.01.01.03 Co-Amoxiclav  125/31.25mg in 5mL Sugar free Suspension
250/62.5mg in 5mL Sugar free Suspension
250/125mg & 500/125mg Tablets

Amoxicillin and clavulanate have good oral bioavailability. The switch from IV to oral should take place as soon as a patient’s clinical condition improves.
05.01.01.03 Co-Amoxiclav  600mg & 1.2g Injection

Amoxicillin and clavulanate have good oral bioavailability. The switch from IV to oral should take place as soon as a patient’s clinical condition improves.
05.01.01.03 Co-Amoxiclav 400mg/57mg Augmentin-Duo® Paediatrics only. Only to be prescribed when three times daily dosing is a problem.
04.09.01 Co-Beneldopa 

Ensure doses are prescribed at exact times as per patient's medication history using the 'free form' option on ePMA

62.5mg, 125mg & 250mg Capsules
62.5mg & 125mg Dispersible Tablets - for NBM patients only.
125mg Sustained Release Tablets 

Generic available. In hospital: contract brand will be supplied.

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise



If nil by mouth consult trust guidelines 336 - The Management of Patients with Parkinson’s Disease in an emergency and when Nil By Mouth.

15.02 Cocaine  10% Topical Solution
04.09.01 Co-Careldopa 

Ensure doses are prescribed at exact times as per patient's medication history using the 'free form' option on ePMA

Generic available. In hospital: contract brand will be supplied.

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise

Carbidopa / levodopa: 12.5/50mg, 10/100mg, 25/ 100mg & 25/250mg 
Carbidopa / levodopa: 25/100mg, 50/200mg Controlled Release tablets

L&D Hospital: If nil by mouth consult trust guidelines 336 - The Management of Patients with Parkinson’s Disease in an emergency and when Nil By Mouth.

04.09.01 Co-Careldopa and Entacapone (Levodopa/Carbidopa/Entacapone) 

Ensure doses are prescribed at exact times as per patient's medication history using the 'free form' option on ePMA

Levodopa 50mg/Carbidopa 12.5mg/Entacapone 200mg Tablets
Levodopa 75mg/Carbidopa 18.75mg/Entacapone 200mg Tablets
Levodopa 100mg/Carbidopa 20mg/Entacapone 200mg Tablets
Levodopa 125mg/Carbidopa 31.25mg/Entacapone 200mg Tablets
Levodopa 150mg/Carbidopa 37.5mg/Entacapone 200mg Tablets
Levodopa 200mg/Carbidopa 50mg/Entacapone 200mg Tablets

Secondary care: the current contract generic product will be supplied against any prescriptions. Generic brands include Sastravi and Stanek.

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise

13.06.02 Co-Cyprindiol 2000/35
(Cyproterone Acetate 2mg with Ethinylestradiol 35micrograms)
 

Generic prescribing (original brand - Dianette<sup>®</sup>).

01.06.02 Co-danthramer 

Restricted for use in palliative (terminally ill) patients only

Contains Dantron & Poloxamer '188'

Oral suspension contains dantron 25 mg with poloxamer ‘188’ 200 mg per 5 mL.

Strong (FORTE) oral suspension contains dantron 75 mg with poloxamer ‘188’ 1 g per 5 mL.

N.B. Capsules no longer available - have been discontinued.

01.06.02 Co-danthrusate 

For terminally ill only.

Only suspension available. The capsules have now been discontinued. 

01.04.02 Codeine  15mg, 30mg tablets
15mg/5ml linctus
04.07.02 Codeine 15mg, 30mg 
03.09.01 Codeine Linctus BP  15mg in 5mL Sugar-free liquid
04.07.02 Codeine Phosphate  60mg/1mL Injection
10.01.04 Colchicine 500microgram 
09.06.04 Colecalciferol 10,000 units/ml 

For Paediatric patients only

Refer to the joint prescribing guidelines below for a guide to dosing for treatment and prevention in children.

09.06.04 Colecalciferol 20,000 , 40,000units 

Refer to the Joint Prescribing Guidelines below for a guide to dosing for treatment and prevention in adults and children or the SPC.

N.B L&D hospital stocks Plenachol brand which is free from gelatin, soya, gluten and peanut oil.  Suitable for vegetarians. Halal and Kosher certified.

09.06.04 Colecalciferol 800 units  800units = 20micrograms
09.06.04 Colecalciferol and Calcium Carbonate 

Hospital contract brands will be supplied in secondary care. Currently Adcal D3 - contains: colecalciferol 400 units / calcium carbonate 1.5g (500mg calcium)

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise

09.06.04 Colecalciferol and Calcium Carbonate 

For swallowing difficulties and enteral feeding tube administration only.

Hospital contract brands will be supplied in secondary care. Currently Adcal D3 Dissolve - contains: colecalciferol 400 units / calcium carbonate 1.5g (500mg calcium)

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise

01.09.02 Colestyramine  4g oral powder
4g sugar-free oral powder
02.12 Colestyramine  Questran® 4g sachet
4g low-sugar sachet (contains aspartame)
05.01.07 Colistimethate inhaler Colobreathe® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - Consultant Microbiology and Respiratory authorisation required before initiating treatment.

05.01.07 Colistimethate Sodium 1 & 2 million units  Colomycin®

Restricted - prescribing by Respiratory Physicians, Consultant Paediatricians and Consultant Microbiologists for use in cystic fibrosis only.
NOTE: Colomycin® injection is licensed for nebulisation and may be given by inhalation as a nebulised solution as an adjunct to standard antibacterial therapy in cystic fibrosis patients with severe pseudomonal chest infections.

05.01.07 Colistimethate Sodium 1 million units generic brands Restricted - for multi-drug resistant infections where there is no alternative.
Must be recommended by a consultant Microbiologist.

Funding cannot be claimed for these indications.
10.03.01 Collagenase  Xiapex® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Approved in line with NICE TA459 for treating Dupuytren’s contracture.
13.10.05 Collodion Flexible BP  Methylated Liquid
01.01.01 Co-magaldrox 

Primary care and Bedford hospital ONLY.

Most cost effective brand to be advised via ScriptSwitch/Optimise

L&D: prescribe Gaviscno Advance.

06.04.01.01 Combined continuous HRT patch Evorel® Conti
06.04.01.01 Combined continuous HRT tablet Kliofem®
06.04.01.01 Combined continuous HRT tablet Kliovance®
06.04.01.01 Combined cyclical HRT patch Evorel® Sequi
06.04.01.01 Combined cyclical HRT tablets Tridestra®
06.04.01.01 Combined sequential HRT tablets Femoston
06.04.01.01 Combined sequential HRT tablets Elleste Duet®
05.01.08 Co-trimoxazole  480mg & 960mg Tablets
240mg/5mL Suspension - Paediatrics only
480mg/5mL Suspension

These must only be prescribed in accordance for the use listed in Luton & Dunstable Trust's antimicrobial guideline or by recommendation from the Consultant Microbiologist.
05.04.08 Co-trimoxazole  See section 5.1.8
05.01.08 Co-trimoxazole 480mg/5mL  Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.
13.08.02 Covermark® 

Classic Foundation

Prior to prescribing, self-care options should be considered.
If NHS Prescribing is required, the following recommendations apply:-
 The prescribing of camouflage creams by clinicians is only supported if the patient has a disfiguring facial condition that is causing distress, impacting in a restrictive way on the patient’s life.
Prior to prescribing:-
 The patient should be referred to a Secondary Care Specialist for advice on optimal management and investigation of any underlying cause.
 The patient should be referred to a trained skin camouflage practitioner for colour matching.

08.01.05 Crizotinib Xalkori®

Commissioned by Not NHSNHS England.
FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

To be prescribed by specialists in line with NICE TA422 and TA529.

13.03 Crotamiton 10% Eurax®

Self-care in Primary Care (purchase OTC).

04.06 Cyclizine 50mg 
04.06 Cyclizine 50mg/1mL   Reserved for palliative care and obstetric patients and patients who cannot have ondansetron.
11.05 Cyclopentolate   0.5% & 1% Preservative free Eye Drops (Minims)
1% Eye Drops
08.01.01 Cyclophosphamide  50mg Tablets

10.01.03 Cyclophosphamide  50mg Tablets
500mg, 1g injection

Also see chapter 08.01.01 for oncology indications
18 Cyproheptadine 4mg Periactin®

For serotonin syndrome.

L&D - In EDC (Pharmacy EDC)

BHT - In Accident & Emergency

08.03.04.02 Cyproterone 

50mg Tablets

06.04.02 Cyproterone Acetate 

Restricted - Prescribing in Gender Dysphoria only on the advice of a specialist centre under shared care arrangements

08.01.03 Cytarabine  unlicensedunlicensed 20mg, 40mg, 44mg, 46mg, 48mg, 50mg, 58mg, 72mg, 82mg, 128mg & 136mg Pre-filled Syringe
unlicensedunlicensed 60mg/3mL Intravenous Injection
08.01.02 Cytarabine - Daunorubicin (liposomal) Vyxeos®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage. OR may be funded through the Cancer Drug Fund. Approved in accordance with the NICE TA below.

02.08.02 Dabigatran 75mg & 110mg Pradaxa®

Refer to NICE TA157/TA249/TA327 AND anti-coagulation guidelines.

N.B. dabigatran is contraindicated in patients with prosthetic heart valves requiring anticoagulant treatment. See MHRA Drug Safety Update Oct 2018 (link in rivaroxaban section below).

08.01.05 Dabrafenib Tafinlar®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted to prescribing in accordance with NICE TA's below.

08.01.05 Dacomitinib Vizimpro®

FOR ALL PRESCRIBING - Blueteq or high cost drug form required - see link from formulary homepage.

To be prescribed by specialists in line with the following NICE TA(s):-

05.01.07 Dalbavancin 500mg 

Restricted to prescribing only when recommended by a consultant Microbiologist for the following, where sensitivities known (all in adults):

  • Acute bacterial skin and skin structure infections
  • Discitis associated with infection in patients unsuitable for hospital @ home (unlicensed)
  • Osteomyelitis in those unsuitable to hospital @ home (unlicensed)
02.08.01 Dalteparin 

Paediatrics only and if recommended by GOSH

02.08.01 Danaparoid 750 Units in 0.6mL Orgaran® Restricted - prescribing only on the advice of a Consultant Haematologist, for heparin induced thrombocytopenia (HIT)
N.B. Very expensive. Consider fondaparinux first.
18 Dantrolene 20mg 

Neuroleptic malignant syndrome (NMS)
Other drug-related hyperpyrexia (consult TOXBASE)

L&D - Kept in Pharmacy EDC and in theatres.

BHT - Kept in Delivery Suite Theatre, Modular Theatre and Upper Theatre Recovery

15.01.08 Dantrolene Sodium 20mg 

Neuroleptic malignant syndrome (NMS)

Other drug-related hyperpyrexia (consult TOXBASE)

Kept in Pharmacy EDC and in theatres.

06.01.02.03 Dapagliflozin 

10mg Film Coated Tablets

Type 1 diabetes: initiation (and continued supervision) of prescribing by Consultant Diabetologist (as per NICE TA) with GP continuation.

Approved in accordance with the following NICE TA(s):-

05.01.10 Dapsone  Restricted - Microbiology authorisation needed

50mg & 100mg Tablets
05.01.07 Daptomycin 350mg & 500mg  Restricted - Microbiology Approval required.
08.01.05 Daratumumab 20mg/mL Darzalex®

Funded by Cancer Drugs Fund if criteria fulfilled in the NICE TAs below.

09.01.03 Darbepoetin Alfa Aranesp®

10microgram, 20microgram, 30microgram, 40microgram & 100microgram Pre-filled Pen

To be prescribed by consultant Haematologist in accordance with NICE TA323 for the treatment of anaemia in patients with cancer who are having chemotherapy.

Also prescribed for renal patients (no longer pbR excluded for this indication).

MUST BE PRESCRIBED ON A HOSPITAL ONLY PRESCRIPTION (more cost-effective)

05.03.01 Darunavir Prezista® 75mg, 150mg, 400mg, 600mg & 800mg Film coated Tablets

Restricted - must be prescribed by HIV consultants only
05.03.01 Darunavir & cobicistat Rezolsta® Darunavir ethanolate 800mg and cobicistat 150mg film-coated tablets

Restricted - must be prescribed by HIV consultants only
05.03.03.02 Dasabuvir 250mg Exviera® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - to be initiated only by a Consultant Gastroenterologist/Hepatologist in accordance with NICE TA365.

08.01.05 Dasatinib Sprycel® Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
To be prescribed by specialists in line with NICE TA425 and TA426.
08.01.02 Daunorubicin  20mg powder for injection
A5.05.02 Debrisoft  Refer to Wound Management Formulary or TVN for appropriate use.
09.01.03 Deferasirox 125mg, 250mg & 500mg Exjade® High Cost drug: prior funding approval required.

To be prescribed in line with the NHS England Commissioning Policy.
For all prescribing contact the Lead Pharmacist for Commissioning Drugs and Homecare on 8048.


09.01.03 Deferiprone  Ferriprox®

High Cost drug: prior funding approval required.

To be prescribed in line with the NHS England Commissioning Policy.
For all prescribing contact the Lead Pharmacist for Commissioning Drugs and Homecare on 8048.


Available as 10mg/1mL oral solution and 500mg tablets

08.03.04.02 Degarelix 80mg, 120mg Firmagon®

Restricted - prescribing by consultant Oncologists or Urologists for the treatment of advanced hormone-dependent prostate cancer in accordance with NICE TA 404. Prescribing may be continued by GPs.

05.01.03 Demeclocycline 150mg  

For use in SIADH only.

Ensure treatment is initiated and reviewed by a consultant endocrinologist or oncologist.

06.06.02 Denosumab 120mg XGEVA®

To be prescribed according to NICE TA265.

Monitor patients for signs and symptoms of hypercalcaemia after discontinuation of denosumab treatment for giant cell tumour of bone. Cases of rebound hypercalcemia have been reported up to 9 months after cessation of treatment.

06.06.02 Denosumab 60mg/1mL  Prolia®

3rd Choice after alendronate and risedronate (or zoledronic acid) for primary and secondary prevention of osteoporosis in-line with NICE TA204.
The initial dose is to be prescribed and administered in secondary
care, subsequent doses to be prescribed and administered in the primary care setting.
NOTE: Prolia® is administered every six months

20 DEPIGMENTING CREAM Pigmanorm®

Prescribing only by Bedford Hospital Dermatology Consultants

BHT - Must not be prescribed on FP10 prescriptions

13.08.02 Dermacolor® 

Camouflage cream

Prior to prescribing, self-care options should be considered.
If NHS Prescribing is required, the following recommendations apply:-
 The prescribing of camouflage creams by clinicians is only supported if the patient has a disfiguring facial condition that is causing distress, impacting in a restrictive way on the patient’s life.
Prior to prescribing:-
 The patient should be referred to a Secondary Care Specialist for advice on optimal management and investigation of any underlying cause.
 The patient should be referred to a trained skin camouflage practitioner for colour matching.

13.02.01 Dermol 500® 

Emollient with antimicrobial. 

Not for long term use.

13.02.01 Dermol® 

Emollient with antimicrobial. 

Not for long term use.

18 Desferrioxamine 2g 

Toxicity with iron.

L&D - Kept in ED antidote cupboard and Pharmacy EDC.

BHT - Kept in Accident & Emergency

09.01.03 Desferrioxamine Mesilate 500mg, 2g  High Cost drug: prior funding approval required.

To be prescribed in line with the NHS England Commissioning Policy.
For all prescribing contact the Lead Pharmacist for Commissioning Drugs and Homecare on 8048.

15.01.02 Desflurane 
06.05.02 Desmopressin  200microgram Tablets
10microgram per metered dose Nasal Spray
06.05.02 Desmopressin  4microgram/1mL Injection
07.03.02.01 Desogestrel 

75microgram Tablets
Stock for Luton Sexual Health Clinic. 

06.03.02 Dexamethasone 

3.3mg/1mL Injection dexamethasone base

Dexamethasone used to be prescribed as dexamethasone phosphate in 4mg doses equivalent to dexamethasone base 3.3mg. There is little clinical difference between these so the DTC has agreed to substitution of whole ampoules of 3.3mg base to be given where a BNF 4mg dose has been prescribed. e.g if 8mg is prescribed administer 2 x 3.3mg ampoules.

Recommendation: better to prescribe in whole 3.3mg units as per manufacturer's SPC (see SPC link)rather than confusing BNF doses.

06.03.02 Dexamethasone 500 microgram, 2mg 





11.04.01 Dexamethasone 0.1%  Maxidex
11.04.01 Dexamethasone 0.1% eye drops single use 

For patients allergic to preservatives

06.03.02 Dexamethasone 2mg/5mL 

Reserved for young children who require doses less than 2mg or those with swallowing difficulties.

11.04.01 Dexamethasone 700micrograms Ozurdex® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved for prescribing by Consultant Ophthalmologist in accordance with NICE TA349, TA229 & TA460.
12.01.01 Dexamethasone with Antibacterial Otomize® 2% Acetic acid/Dexamethasone 0.1% & Neomycin Sulphate 3250units/1mL Ear spray
12.01.01 Dexamethasone with Antibacterial Sofradex® 0.05% Dexamethasone/Framycetin Sulphate 0.5% & Gramicidin 0.005% Ear drops
11.04.01 Dexamethasone with Neomycin and Polymyxin B sulphate Maxitrol®
04.04 Dexamfetamine 

5mg Tablets
Only to be initiated by specialist in ADHD according to NICE TA98.

Follow shared care guidance below.

15.01.04.04 Dexmedetomidine  Dexdor® 200micrograms/2mL, 400micrograms/4mL

Restricted - prescribing by Consultant Anaesthetists on ITU.
04.07.02 Diamorphine 5mg, 10mg, 30mg, 100mg, 500mg  Higher strengths (100mg & 500mg) ordered on a named patient basis only. Write patient's name and hospital number in CD order book.
04.07.02 Diamorphine 720microgram or 1600microgram/ actuation Ayendi®

Approved for its licensed indication of treatment of acute severe pain in children in the Emergency Department. This is a controlled drug and there is a detailed SOP that must be followed for administration and documentation of this product in the Emergency Department.

04.01.02 Diazepam  10mg/2mL Injection

Note: Diazepam injection comes in two forms - solution (IM or IV) and emulsion Diazemuls® (IV only). Emulsion is preferred for IV as it is less irritant to the vein.
04.01.02 Diazepam  2mg, 5mg & 10mg Tablets
2mg in 5mL Oral Solution
2.5mg, 5mg & 10mg Rectal Tube
04.08.02 Diazepam 10mg/2mL  Note: Diazepam injection comes in two forms - solution (IM or IV) and emulsion Diazemuls® (IV only). Emulsion is preferred for IV as it is less irritant to the vein.
10.02.02 Diazepam 2mg, 5mg, 10mg 
06.01.04 Diazoxide 50mg/mL 

For the management of neonatal hypoglycaemia.

50mg tablets can be used if liquid is not available. 

10.01.01 Diclofenac 

Following new safety data (see below) the use of diclofenac is restricted to use where the risks and benefits of continued treatment have been considered.
All decisions to initiate or continue use of diclofenac should be clearly documented and communicated across healthcare interfaces.

50mg Tablets
75mg Sustained Release Tablets (not routinely stocked)
12.5mg, 25mg, 50mg & 100mg Suppositories
75mg/3mL injection

11.08.02 Diclofenac Sodium Voltarol® Ophtha multidose
18 Dicobalt edetate 300mg/20mL 

Cyanide toxicity

L&D - Kept in ED antidote cupboard.

BHT - Kept in Accident & Emergency

08.03.01 Diethylstilbestrol 

1mg Tablets

Restricted - to use in breast and prostate cancer

02.01.01 Digoxin 

500mcg in 2mL 100micrograms in 1mL - for paediatric use only.

Approximate bioavailability equivalences: 75microgram IV : 100microgram elixir : 125mcg tablet

02.01.01 Digoxin  62.5, 125, & 250micrograms 

Approximate bioavailability equivalences:
75microgram IV :  100microgram elixir : 125mcg tablet

02.01.01 Digoxin 50micrograms in 1mL 

Approximate bioavailability equivalences:
75microgram IV :  100microgram elixir : 125mcg tablet

02.01.01 Digoxin specific antibody fragments Digifab® Consult ToxBase for dosing and administration
Seek specialist advice before initiating treatment
Available in the Emergency Drug Cupboard via 555 bleep holder
Intravenous infusion only
40mg vials

18 Digoxin specific antibody fragments 40mg Digifab®

L&D - Kept in Pharmacy EDC fridge.

BHT - contact Pharmacy (Oncall Pharmacist via switchboard out of hours)

04.07.02 Dihydrocodeine 30mg  
04.07.02 Dihydrocodeine 60mg m/r tablets DHC Continus®

Approved for use as part of the C-section pathway only

01.07.04 Diltiazem 2% 

Cream - unlicensed.

Second-line only. Restricted -  for the treatment of patients with an anal fissure resistant to topical glyceryl trinitrate 0.4% used twice daily or experiencing severe side effects (headache) from it.

02.06.02 Diltiazem 120mg, 180mg, 200mg, 240mg, 300mg 

ONCE A DAY dosing - 24 hour release profile.

Brands include: ADIZEM XL, DILZEM XL, TILDIEM LA. Ideally continue same brand if possible.

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise






02.06.02 Diltiazem 60mg 

THREE TIMES DAILY dosing (TWICE DAILY in elderly).

02.06.02 Diltiazem 90mg, 120mg, 180mg 

TWICE DAILY dosing.

Brands include Adizem SR, Dilzem SR and Tildiem Retard. Ideally continue same brand if possible.

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise

08.02.04 Dimethyl fumarate 120mg & 240mg Tecfidera®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in line with NICE TA320 for relapsing-remitting multiple sclerosis.

Must not be prescribed on FP10 prescriptions

08.02.04 Dimethyl fumarate 30mg, 120mg Skilarence®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Prescribing by specialist in accordance with NICE TA475.

Must not be prescribed on FP10 prescriptions

13.10.04 Dimeticone 4% Hedrin®

For inpatient use only, not to be prescribed on TTA.

Self-care in primary care

07.01.01 Dinoprostone  750 micrograms/0.75mL Injection
07.01.01 Dinoprostone Prostin E2®

1mg & 2mg Vaginal Gel
10mg MR Pessaries (releasing 10mg over approx. 24 hours)

3mg vaginal tablets

08.02.03 Dinutuximab Qarziba®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA538.

14.04 Diphtheria, tetanus, pertussis (acellular) and poliomyelitis (inactivated) Boostrix-IPV®

For boosters in children aged 3 years and over and adults.

14.04 Diphtheria, Tetanus, Pertussis (acellular) and Poliomyelitis (inactivated) Repevax®

For booster vaccination according to the national UK immunisation schedule .

14.04 Diphtheria, Tetanus, Pertussis (acellular) and Poliomyelitis (inactivated) Infanrix IPV®

For booster vaccination according to the national UK immunisation schedule .

14.04 Diphtheria, tetanus, pertussis (acellular), hep B, poliomyelitis (inactivated) and Hib Infanrix hexa®

For primary vaccination according to the national UK immunisation schedule 

02.09 Dipyridamole  100mg Tablets
200mg Sustained Release Capsules
50mg in 5mL Suspension
06.06.02 Disodium Pamidronate 

15mg, 30mg, 60mg, 90mg Injection

02.03.02 Disopyramide  100mg Capsules
04.10.01 Disulfiram Antabuse®

Restricted - only to be prescribed by a specialist in drug and alcohol problems 

200mg Tablets

13.05.02 DITHRANOL 0.1% /0.25%,0.5%,1%,2%,4% in Lassar’s paste 

unlicensed unlicensed

13.05.02 Dithranol 0.1%, 0.25%, 0.5%, 1% & 2% Dithrocream®
13.05.02 Dithranol 3% Micanol®
02.07.01 Dobutamine  250mg in 5mL Injection
08.01.05 Docetaxel Taxotere®

10mg/0.5mg & 20mg/1mL Injection
unlicensedunlicensed 60mg - 190mg in 0.9% Sodium Chloride Infusion (250mL)

Approved in accordance with NICE TA's below for the treatment of early node-positive breast cancer and hormone-refractory metastatic prostate cancer. For more information click the link below

01.06.02 Docusate Sodium  100mg Capsules
50mg in 5ml oral liquid

12.5mg in 5ml paediatric oral liquid (sugar free)
05.03.01 Dolutegravir  50mg Film Coated Tablets

Restricted - must be initiated by GUM & Microbiology consultants only

Switch to raltegravir where possible
05.03.01 Dolutegravir & lamivudine Dovato®

Dolutegravir sodium equivalent to 50 mg dolutegravir and 300 mg lamivudine.

Restricted - prescribing by HIV Consultants only in accordance with BHIVA guidelines and NHSE Clinical Commissioning policy.

05.03.01 Dolutegravir & rilpivirine Juluca®

Dolutegravir sodium equivalent to 50 mg dolutegravir and 25mg rilpivirine.

Restricted - prescribing by HIV Consultants only in accordance with BHIVA guidelines and NHSE Clinical Commissioning policy.

05.03.01 Dolutegravir, abacavir & lamivudine Triumeq® Dolutegravir 50mg/Abacavir 600mg/Lamivudine 300mg Flim Coated Tablets

Restricted - prescribing by HIV Consultants only in accordance with BHIVA guidelines and NHSE Clinical Commissioning policy.

Switch to raltegravir PLUS generic abacavir / lamivudine where possible
04.06 Domperidone  10mg Tablets
5mg/5mL Suspension

Restricted - MHRA have advised domperidone should only be used for nausea and vomiting. Its use is contraindicated in patients with underlying cardiovascular conditions and risk factors. Dose and duration have been revised to a maximum of 10mg three times daily for one week in adults. For more details see MHRA link below
04.11 Donepezil  5mg & 10mg Tablets
10mg Orodispersible Tablet

Restricted to prescribing by Consultant Psychiatrists, Neurologists and physicians specialising in the care of the elderly, with continuation by GPs, in accordance with NICE TA217.
02.07.01 Dopamine  200mg in 5mL Injection
05.03.01 Doravirine  Pifeltro®

Restricted - must be prescribed by HIV consultants only in accordance with BHIVA guidelines and NHSE Clinical Commissioning policy.


100mg tablets

05.03.01 Doravirine/ lamivudine/ tenofovir disproxil  Delstrigo ®

Restricted - prescribing by HIV Consultants only in accordance with BHIVA guidelines and NHSE Clinical Commissioning policy.

Contains 100mg of doravirine, 300mg of lamivudine and 300 mg of tenofovir disoproxil fumarate (equivalent to 245mg of tenofovir disoproxil)

03.07 Dornase Alfa 2.5mg (2500 units) / 2.5mL Pulmozyme®

Specialist prescribing for:

1. Cystic fibrosis patients according to NICE guidelines. Funded by NHS England.

2. Respiratory consultants for the management of severe empyema together with intrapleural aleplase following the attached protocol.

11.06 Dorzolomide with Timolol   Dorzolomide 2%/Timolol 0.5% Eye Drops
N.B. Must prescribe generically on FP10.
03.05.01 Doxapram  100mg in 5mL Injection
02.05.04 Doxazosin 

1mg, 2mg & 4mg Tablets 

07.04.01 Doxazosin  1mg, 2mg, 4mg tablets.

Modified release tablets non-Formulary since no evidence of superiority and non-MR tablets can be given once daily.
08.01.02 Doxorubicin Hydrochloride  10mg/5mL, 20mg/10mL, 35mg/17.5mL & 60mg/30mL Syringe
unlicensedunlicensed 40mg in 5% Glucose Infusion (250mL)



05.01.03 Doxycycline 100mg 
05.01.03 Doxycycline 100mg  NOTE: much greater cost - only prescribe when standard oral formulation is unsuitable.
05.01.03 Doxycycline 100mg/5mL  unlicensedunlicensed

Restricted - Microbiology approval required. Stored in fridge.
N.B. Brand stocked may vary. For Doxyhexal SF dilute to at least 0.5mg/mL:

100mg in 250mL glucose 5% or sodium chloride 0.9% over 1 hour
or
200mg in 500mL glucose 5% or sodium chloride 0.9% over 2 hours

Give via a large vein and take care to avoid extravasation

For Doxycyclin RatioPharm SF: follow guidance on IVGUIDE.
02.03.02 Dronedarone Multaq®

Only to be initiated and monitored under specialist supervision by a Consultant Cardiologist in line with NICE TA197
400mg Tablets

04.06 Droperidol 2.5mg/1mL Xomolix®

Approved for off-label intramuscular injection of 5mg dose for the Emergency Department only. Prescribing to be by ED consultants or registrars.

03.01.05 Drug Delivery Device Volumatic®

Large volume spacer

Available with or without mask

Solid adaptor only fits specific MDIs including all Chiesi and GSK devices

Perceivable valve movement.

03.01.05 Drug Delivery Device Able Spacer®

Available with or without mask

Low static properties

Perceivable valve movement 210ml

03.01.05 Drug Delivery Device Space Chamber Plus®

Fits most MDIs

Perceivable valve movement

Standard and compact sizes

With or without facemask (small, medium large)

03.01.05 Drug Delivery Device A2A Spacer®

Universal adaptor (all MDIs)

Collapsible, pocket sized

Available with or without mask

Compatible with all pMDIs Low static properties

Perceivable valve movement

210ml

03.01.05 Drug Delivery Device AeroChamber Plus Flow-Vu®

Antistatic

Visible value movement

One size chamber

With or without facemask small (0-18m), medium (1-5 years), small adult, large adult

06.01.02.03 Dulaglutide 0.75mg, 1.5mg Trulicity®

Third Choice

For specialist initiation in-line with JPC guidance and shared care guideline (see link below).

04.03.04 Duloxetine 30mg, 60mg 

Specialist initiation for GAD or depression

04.07.03 Duloxetine 60mg 

Third-line choice for neuropathic pain or first-line for diabetic neuropathy in accordance with JPC guidance. See link below.

60mg capsules only for this indication.

13.05.01 Dupilumab Dupixent®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA534 for the treatment of moderate to severe atopic eczema.

08.01.05 Durvalumab 50 mg/ml concentrate solution for infusion Imfinzi®

FOR ALL PRESCRIBING - Blueteq or High Cost Drug Form required - see link from Formulary Home Page.

Funded by the Cancer Drugs Fund if criteria fulfilled as per the following NICE TA (s)

06.04.02 Dutasteride Avodart®

For 2nd-line use after finasteride

02.08.02 Edoxaban 30mg & 60mg Lixiana®

Refer to NICE TA354/TA355 AND anti-coagulation guidelines.

N.B. edoxaban has not been studied in patients with prosthetic heart valves and its use is not recommended in these patients (see MHRA DSU Oct 18 link under rivaroxaban).

15.01.06 Edrophonium 

unlicensedunlicensed 10mg/1mL Injection 


N.B. not routinely stocked. 

10.02.01 Edrophonium Chloride  unlicensedunlicensed 10mg/1mL Injection

N.B. not routinely stocked.
05.03.01 Efavirenz  Restricted - must be prescribed by HIV consultants only

200mg Capsules
600mg Film Coated Tablets
13.09 Eflornithine 11.5% 

Low-priority funding, prescribing should only be considered in exceptional circumstances. Please refer to JPC guidance on place in therapy and prescribe accordingly.

  • Self-funded cosmetic treatments for reduction in hair growth or hair removal (e.g. shaving, plucking, laser treatment, electrolysis) should be the primary options for the majority of women with hirsutism.
  • It is important that the patient is properly assessed and underlying causes addressed (such as weight reduction if obese) before pharmacological therapy is considered as hirsutism can result from serious medical conditions or from medication (e.g. ciclosporin, glucocorticoids, minoxidil, phenobarbitone, phenytoin, combined oestrogen-androgen hormone replacement therapy).

 

05.03.03.02 Elbasvir & grazoprevir 50mg/ 100mg Zepatier® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted - to be prescribed by a Consultant Gastroenterologist/Hepatologist in accordance with NICE TA413
Elbasvir 50 mg/ grazoprevir 100 mg tablets.
09.01.04 Eltrombopag 25mg, 50mg Revolade®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA293 for the treatment of chronic immune thrombocytopenic purpura

N.B. May interfere with bilirubin and creatinine test results. See MHRA link for further information. Any clinical concerns contact the Clinical Biochemistry team on bleep 237.

01.06.06 Eluxadoline 75mg, 100mg Truberzi® Eluxadoline is recommended, within its marketing authorisation, as an option for treating irritable bowel syndrome with diarrhoea in adults fulfilling the criteria in NICE TA471.
06.01.02.03 Empagliflozin  10mg & 25mg Film Coated Tablets

Approved in accordance with TA336 or TA390 for the treatment of type 2 diabetes in adults.
05.03.01 Emtricitabine 200mg, Rilpivirine 25mg and Tenofovir 245mg Eviplera® Emtricitabine 200mg/Rilpivirine 25mg/Tenofovir Disproxil 245mg

Restricted - must be prescribed by HIV Consultants only
13.02.01 Emulsifying Ointment BP 
02.05.05.01 Enalapril   2.5mg, 5mg, 10mg & 20mg Tablets
08.01.05 Encorafenib 50mg, 75mg Braftovi ®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved for use with binimetinib in accordance with the NICE TA below.

02.08.01 Enoxaparin  For treatment of ACS in renal patients only:

60mg in 0.6mL Injection
80mg in 0.8mL Injection
100mg in 1mL Injection
120mg in 0.8mL Injection
150mg in 1mL Injection

04.09.01 Entacapone  200mg Tablets
05.03.03.01 Entecavir 500microgram, 1mg Baraclude® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - to prescribing by Consultant Gastroenterologists for hepatitis B in accordance with NICE TA 153.



08.03.04.02 Enzalutamide 40mg Xtandi®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA377 and TA316 for the treatment of hormone-relapsed prostate cancer.

13.02.01 Epaderm® 

Cream & Ointment. 

02.07.02 Ephedrine  30mg in 10mL pre-filled syringe
30mg in 1mL injection
12.02.02 Ephedrine 0.5% 
08.01.02 Epirubicin hydrochloride  unlicensedunlicensed 10mg/5mL, 20mg/10mL, 30mg/15mL & 60mg/30mL Syringe
50mg/25mL Injection Solution

02.02.03 Eplerenone 

25mg & 50mg Film-Coated Tablets

For 2nd-line use after spironolactone.

09.01.03 Epoetin alfa Eprex®

200Unit/0.5mL, 8000Unit/0.8mL, 10000Unit/1mL, 20000Unit/0.5mL, 30000Unit/0.75mL & 40000Unit Injection

To be prescribed by consultant Haematologist for licensed indications or in accordance with NICE TA323 for the treatment of anaemia in patients with cancer who are having chemotherapy.

Also prescribed in renal patients (no longer a pBR excluded drug).

MUST BE PRESCRIBED ON A HOSPITAL ONLY PRESCRIPTION (more cost-effective)

02.08.01 Epoprostenol 500mcg Generic brand

Restricted - for use on NICU, ITU and SCBU and in reynaud's disease by rheumatologists.

N.B. Must not use Flolan brand with L&D protocol as the formulation has changed (April 2017)and no longer works with the protocol. (The new Flolan formulation has a pH of 12, is diluted to a different concentration and has shorter stability).

09.06.04 Ergocalciferol 

7.5mg/1mL (300,000 unit) Injection

No longer advised.

Only prescribe when patients unable to take or comply with oral treatment. Refer to the joint prescribing guidelines below for a guide to dosing for treatment and prevention in adults and children.

07.01.01 Ergometrine   500microgram/1mL Injection
08.01.05 Eribulin Halaven®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Commissioned by Not NHSNHS England.

To be prescribed by specialists in line with NICE TA423 & TA515.

08.01.05 Erlotinib Tarceva® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
100mg & 150mg Tablets

Restricted to prescribing in line with NICE TA258 & TA374.
05.01.02.02 Ertapenem 1g   Restricted - Microbiology Approval required.

N.B. Do not prescribe concurrently with sodium valproate, valproic acid or valproate semisodium due to the major drug interaction. Valproic acid levels are reduced by 60 to 100% within 2 days
06.01.02.03 Ertugliflozin 15mg  Steglatro®

Use in accordance with NICE TA (s) below.

 

05.01.05 Erythromycin  250mg Tablets
500mg/5mL, 125mg/5mL & 250mg/5mL oral suspension (sugar-free)


13.06.01 Erythromycin 40mg with Zinc Acetate 12mg/mL Zineryt®
05.01.05 Erythromycin Lactobionate 1g   Restricted - used as a prokinetic agent in critical care patients.
04.03.03 Escitalopram  Cipralex®

5mg, 10mg & 20mg Tablets
20mg/1mL Sugar-Free Oral Drops

Max 10mg in elderly patients due risk of QT prolongation - see MHRA warning below

02.04 Esmolol  100mg in 10mL Injection
01.03.05 Esomeprazole  

20mg, 40mg capsules

For ongoing treatment or initiation by a gastroenterology or specialist surgical consultant for 3rd-line use after omeprazole and lansoprazole.

06.04.01.01 Estradiol valerate Progynova®

Restricted - Prescribing in Gender Dysphoria only on the advice of a specialist centre under shared care arrangements

10.01.03 Etanercept Benepali®, Enbrel® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Must be prescribed by Consultant Rheumatologist in accordance with NICE TA199, TA383, TA375.

10mg/mL, 25mg/1mL & 50mg/1mL Injection
50mg/1mL Pre-filled Syringe or pen

NOTE:
ALL prescribing of etanercept must be by brand name.
Benepali® is first choice etanercept preparation for the treatment of patients greater than 18 years with rheumatoid arthritis (NICE TA199/375), psoriatic arthritis (NICE TA199) and ankylosing spondylitis (NICE TA383)
Enbrel® is the treatment of choice for initiation in patients who are less than 18 years of age, those with juvenile idiopathic arthritis (JIA) and those requiring a dose of 25mg

See section 13.05.03 (for Dermatology)


13.05.03 Etanercept Enbrel® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

50mg/1mL Pre-filled Pen (Benepali)
50mg/1mL Pre-filled Syringe (Benepali)

10mg/1mL, 25mg/1mL & 50mg/1mL Injection (Enbrel)
25mg/1mL & 50mg/1mL Pre-filled Syringe (Enbrel)

Approved in accordance with NICE TA103 & TA455 for the treatment of severe plaque psoriasis.

Restricted - must be initiated by a Dermatology consultant only and must be prescribed by generic and brand name
09.05.01.02 Etelcalcetide 2.5mg, 5mg, 10mg Parsabiv®
Approved in accordance with NICE TA448 for treating secondary hyperparathyroidism.
05.01.09 Ethambutol 100mg, 400mg 
05.01.09 Ethambutol 400mg/5ml  

Red unlicensed Unlicensed ethambutol 400mg/5ml liquid available for paediatric patients on advice of Specialist Tuberculosis Clinic when tablets are not suitable

18 Ethanol (alcohol) injection 100% 

Toxicity with methanol and ethylene glycol

L&D - Kept in ED antidote cupboard and Pharmacy EDC.

BHT - Contact Pharmacy (Oncall Pharmacist via switchboard out of hours)

06.04.01.01 Ethinylestradiol 

10microgram tablets

Restricted to paediatrics and gender dysphoria use only.

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

07.03.01 Ethinylestradiol 20mcg / desogestrel 150mcg Gedarel® Stock for Luton Sexual Health Clinic.
07.03.01 Ethinylestradiol 30 mcg / drospirenone 3 mg Yasmin®

Restricted to Luton Sexual Health Clinic.

For continuation only. Most patients recommended to switch to pills with lower DVT risks

07.03.01 Ethinylestradiol 30 mcg / levonorgestrel 150 mcg  Stock for Luton Sexual Health Clinic.
07.03.01 Ethinylestradiol 30mcg / desogestrel 150mcg Gedarel® Stock for Luton Sexual Health Clinic.
07.03.01 Ethinylestradiol 35 mcg / norgestimate 250 mcg 

Stock for Luton Sexual Health Clinic.

Most cost effective brand to be advised via ScriptSwitch/Optimise

04.08.01 Ethosuximide 

50mg in 1mL Oral Solution

May be prescribed generically.

15.01.01 Etomidate  20mg/10mL Injection
07.03.02.02 Etonorgestrel Nexplanon® Training is required to adminster these devices.
08.01.04 Etoposide  100mg/5mL Injection
50mg Capsules
unlicensedunlicensed 120mg in 0.9% Sodium Chloride Infusion (500mL)
unlicensedunlicensed 140mg - 260mg in 0.9% Sodium Chloride Infusion (1000mL)

05.03.01 Etravirine  Restricted - must be prescribed by HIV consultants only

200mg Tablets
18 European Viper Venom Antivenom 

L&D - Kept in ED fridge.

BHT - Kept in Accident & Emergency (Fridge)

08.01.05 Everolimus Afinitor® Commissioned by Not NHSNHSEngland for some indications.
FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

To be prescribed by specialists in line with NICE TA421, TA432 & TA449.
02.12 Evolocumab 140mg/mL Repatha® FOR ALL PRESCRIBING - a completed and approved HIGH COST DRUG compliance form is required. Complete on Blueteq (link on front page).

Prescribing initiation and continuation by Consultant Chemical Pathologist only.

For treatment of primary hypercholesterolaemia (heterozygous familial and non-familial) and mixed dyslipidaemia in accordance with NICE TA394 (evolocumab).
08.03.04.01 Exemestane 25mg 
06.01.02.03 Exenatide prolonged release Bydureon▼®

Restricted - to prescribing by Diabetologists only, in accordance with NICE TA248.

2mg MR pre-filled pen (has now replaced syringe and vial)

02.12 Ezetimibe 10mg Ezetrol® In accordance with NICE TA385
10.01.04 Febuxostat 80mg , 120mg Adenuric® Restricted - prescribing when recommended by Rheumatology team. Only for the management of chronic hyperuricaemia in gout for people intolerant of allopurinol or for whom it is contraindicated and in accordance with NICE TA164.
N.B. be aware of drug safety update.

02.12 Fenofibrate 200mg, 267mg 
04.07.02 Fentanyl Effentora®

Restricted to initiation by palliative care team only.

100microgram, 200microgram & 400microgram Buccal Tablets

Not to be prescribed on TTA's. Not recommended by NHSEngland (guidance on low value medicines). 

04.07.02 Fentanyl 

Releasing 12microgram, 25microgram, 50microgram, 75microgram & 100microgram per hour over 72 hours.

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfil the legal requirements of controlled drug prescriptions. e.g. Please supply Five (5) patches (signed).

N.B. pack size is 5 patches.

15.01.04.03 Fentanyl  100microgram/2mL, 500microgram/10mL Injection
09.01.01.02 Ferric Carboxymaltose Ferinject®

100mg/2mL & 500mg/10mL Injection


L&D: Restricted - Haematology, Gastroenterology (IBD patients) or Paediatrics (IBD patients) and obstetric patients.

09.01.01.01 Ferrous Fumarate  210mg Tablets (Equivalent to 68mg elemental iron)

140mg/5mL syrup (Equivalent to 45mg elemental iron)
09.01.01.01 Ferrous Sulphate  200mg Tablets
Equivalent to 65mg elemental iron

07.04.02 Fesoterodine 

4mg & 8mg Modified-Release Tablets

03.04.01 Fexofenadine 120mg & 180 mg  

For use when first-line options not effective.

05.01.07 Fidaxomicin 200mg 

Restricted - Microbiology Approval required.
Approved by DTC for 3rd line treatment of C.difficile.


Only to be prescribed by GPs on the advice of a microbiologist

09.01.06 Filgrastim Neupogen® Paediatrics only
30 Mega Unit 0.3mg/1mL Injection
0.6mg/1mL & 300microgram/0.5mL Injection
09.01.06 Filgrastim Zarzio®

Consultant recommendation for licensed indications.

Up to 85kg: 30 million-units (300micrograms) pre-filled syringe

If > 85kg use: 48 million-units (480micrograms) pre-filled syringe

06.04.02 Finasteride 5mg 

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

08.02.04 Fingolimod 500microgram  FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in-line with NICE TA254.
A5.03.04 Flaminal Forte Gel  On recommendation of TVN.
A5.03.04 Flaminal Hydro Gel   On recommendation of TVN.
06.01.06 Flash Glucose Monitoring System FreeStyle Libre®

Use restricted in line with JPC/national guidance:

FreeStyle Libre criteria

02.03.02 Flecainide  50mg & 100mg Tablets
02.03.02 Flecainide 150mg in 15mL 

unlicensed  Unlicensed

Stocked in the L&D EDC.

Licensed product was discontinued

05.01.01.02 Flucloxacillin  250mg, 500mg & 1g Injection
05.01.01.02 Flucloxacillin  250mg & 500mg Capsules
125mg & 250mg in 5ml oral suspsension
05.02.01 Fluconazole 

50mg, 150mg & 200mg Capsules
50mg/5mL & 200mg/5mL Suspension

Not to be prescribed for the treatment of Fungal Nail Infections

05.02.01 Fluconazole  50mg/25mL, 100mg/50mL, 200mg/100mL & 400mg/200mL IV Infusion

Restricted - Microbiology or Consultant approval required.
05.02.05 Flucytosine 2.5g/250mL  Restricted - Microbiology approval required.
08.01.03 Fludarabine Phosphate Fludara® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
10mg Tablets
50mg Injection Solution

Approved in accordance with NICE TA29 for the treatment of B-cell chronic lymphocytic leukaemia. It is not recommended to prescribe fludarabine on its own as an initial treatment for chronic lymphocytic leukaemia.

06.03.01 Fludrocortisone  100microgram Tablets
Florinef® brand discontinued April 2016
15.01.07 Flumazenil  500microgram/5mL Injection
18 Flumazenil 500mcg/5mL 

Reversal of iatrogenic over-sedation with benzodiazepines.
Use with caution in patients with benzodiazepine poisoning, particularly in mixed drug overdoses; contraindicated in mixed TCA/benzodiazepine overdose.

L&D - Kept in ED, Pharmacy EDC and any wards / departments using benzodiazepines.

BHT - Kept in Accident & Emergency and any wards / departments using benzodiazepines

12.01.01 Flumetasone 0.02% with Clioquinol 1% 
12.01.01 Fluocinolone 0.25mg/ml + Ciprofloxacin 3mg/mL Cetraxal Plus®

Indicated in adults and in children aged 6 months and older for the following infections caused by ciprofloxacin susceptible microorganisms: 

  • Acute otitis externa (AOE)
  • Acute otitis media in patients with tympanostomy tubes (AOMT)

Presented in single-dose 0.25mL containers.

11.04.01 Fluocinolone 190microgram  Iluvien®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

For prescribing by consultant Ophthalmologist in accordance with the following NICE TAs:

NB - NICE TA 613 is NEGATIVE - not recommended for treating chronic diabetic macular oedema in phakic eyes after an inadequate response to previous therapy.

13.04 Fluocinolone Acetonide 0.0025% Synalar 1 in 10 Dilution®

Mild

13.04 Fluocinolone Acetonide 0.00625% Synalar 1 in 4 Dilution®

Moderately Potent

13.04 Fluocinolone Acetonide 0.025% Synalar®

Very Potent

11.07 Fluorescein Sodium  1% & 2% Single dose Eye Drops - Preservative Free
unlicensedunlicensed 20% Injection
11.04.01 Fluorometholone FML®

0.1% Eye Drops

08.01.03 Fluorouracil  2.5g Injection
unlicensedunlicensed 50mg/2mL 100mg/4mL, 200mg/8mL & 500mg/20mL Syringe
unlicensedunlicensed 1250mg - 2400mg/252mL LV1.5 Infuser device Infusion
unlicensedunlicensed 1250mg - 2650mg/84mL SV0.5 Infusor device Infusion
unlicensedunlicensed 2100mg - 4800/220mL LV5 Infusor device Infusion

13.08.01 Fluorouracil 5% Efudix®
04.03.03 Fluoxetine  20mg Capsules
20mg/5mL Oral Liquid

Fluoxetine (in combination with psychological therapy) is the first choice SSRI for initial treatment of moderate to severe depression in young people (12–18 years)


04.03.04 Flupentixol 

500microgram & 1mg Tablets

04.02.02 Flupentixol Decanoate 

Specialist initiation and continuation

11.08.02 Flurbiprofen Sodium 0.03% 
09.05.03 Flurides Duraphat® (Toothpaste)

For Bedford Hospital inpatients only.

Selfcare - In Primary Care patients advised to purchase over the counter.

08.03.04.02 Flutamide 

250mg Tablets

12.02.01 Fluticasone furoate Avamys®

Most cost-effective brand in Primary care.

03.02 Fluticasone furoate & vilanterol Relvar Ellipta®

Approved by JPC  as a 1st line choice ICS / LABA option for the treatment of COPD.

 

JPC Bulletin280: Fluticasone/vilanterol 92/22 micrograms inhalation powder (Relvar Ellipta) for the treatment of COPD

The JPC also approved the device as an option for the treatment of asthma in the following patients only:

  •  young people who have ‘difficult to control’ asthma and who are under the care of a Specialist outreach team and tertiary centre.

JPC Bulletin 282: Fluticasone furoate/ Vilanterol (Relvar®Ellipta® ) for the treatment of Asthma (select group of patients)

03.01.04 Fluticasone furoate/ umeclidinium/ vilanterol 92/55/22 micrograms inhalation powder Trelegy® Ellipta®

Approved by JPC as a  as a joint 1st-line triple therapy option (ICS / LAMA/ LABA) for the treatment of COPD. 

JPC Bulletin 281: Fluticasone furoate/ umeclidinium/ vilanterol 92/55/22 micrograms inhalation powder (Trelegy® Ellipta®) for the treatment of COPD

03.02 Fluticasone propionate Flixotide® 50, 125, 250 micrograms Evohaler
50, 100, 250, 500 micrograms dry powder inhaler (Accuhaler)

N.B. Most expensive of the steroid inhalers.
12.02.01 Fluticasone propionate Flixonase Aqueous®

Most cost-effective brand in Secondary care.

12.02.01 Fluticasone Propionate 400mcg Flixonase Nasule®

Prescribing by ENT consultants for nasal polyps.

03.02 Fluticasone propionate and formoterol Flutiform® Corticosteroid and long-acting beta agonist (ICS/LABA).

125microgram fluticasone/ 5microgram formoterol
250microgram fluticasone/ 10microgram formoterol
03.02 Fluticasone propionate and salmeterol 

Corticosteroid and long acting beta agonist (ICS/LABA).

100microgram, 250microgram & 500microgram Accuhaler
50microgram, 125microgram & 250microgram Evohaler

Hospitals: contract brand will be supplied (Seretide).

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise

04.03.03 Fluvoxamine Maleate Fluvoxamine®

For specialist initiation or on the advice of a Mental Health Specialist

09.01.02 Folic Acid  400microgram & 5mg Tablets
2.5mg/5mL Sugar-free Solution
18 Fomepizole 10 

For emergency treatment of ethylene glycol and methanol poisoning in accordance with National Poisoning Information Centre (Toxbase) recommendations.

L&D - Kept in ED antidote cupboard

BHT - Kept on ICU

02.08.01 Fondaparinux 2.5mg in 0.5mL  Arixtra® Restricted to:
1. Prescribing by acute medical team for suspected ACS. Refer Trust Guidelines.
2. Prescribing by Consultant Haematologists for patients intolerant of tinzaparin and enoxaparin (eg. due to heparin-induced thrombocytopenia (HITT) or skin rash)
03.01.01.01 Formoterol 12mcg per dose 

First choice beta2-agonist in Primary care.

03.01.01.01 Formoterol 12mcg per dose 

Metered dose inhaler

First choice beta2-agonist in Primary care

05.03.02.02 Foscarnet Sodium Foscavir® Restricted - must be initiated by GUM or Microbiology consultants

05.01.13 Fosfomycin 3g 

Restricted - to be prescribed on the recommendation of Microbiology based on sensitivity results.

Fosfomycin should be used as last line treatment. 

N.B. this is contraindicated in severe renal impairment (CrCl < 10mL/min).

20 FOSFOMYCIN Sachets 3g  3g Sachet

Fosfomycin should be used as last line treatment. A dose should be repeated after 3 days.
Creatinine clearance <80ml/min, including the physiological reduction in the elderly, increases the halflife of fosfomycin therefore repeat after 5 days.

Restricted - to be prescribed on the recommendation of microbiology sensitivity results.
04.07.04.02 Fremanezumab Anovy®

FOR ALL PRESCRIBING - Blueteq or high cost drug form required - see link from formulary homepage.

 

Foe use in accordance with the following TA(s) only:

04.07.04.01 Frovatriptan 

Frovatriptan should only be prescribed for the prevention of menstrual related migraine and should not be prescribed for the acute treatment of migraine (local joint formulary decision)

 

 

02.02.02 Furosemide 

20mg in 2mL

50mg in 5mL

250mg in 25mL

02.02.02 Furosemide  

20mg in 5mL

40mg in 5mL

02.02.02 Furosemide 20mg, 40mg & 500mg  



11.03.01 Fusidic Acid  1% Viscous Eye Drops

Restricted to use where chloramphenicol unsuitable.
N.B cost increased to around £35 per tube(used to be about £2)
13.10.01.02 Fusidic Acid 2% Fucidin®
05.01.07 Fusidic acid 250mg/5mL  For penicillin resistant staphylococcus or according to local guidelines or on microbiology advice.
Must always be prescribed with another antobiotic.

N.B. Lower bioavailability than tablets.

500mg tablets = 750mg liquid
04.07.03 Gabapentin 

100mg, 300mg & 400mg Capsules

Ensure loading regime is prescribed when initiated therapy for neuropathic pain to reduce side effects. 300mg OD 1/7, 300mg BD 1/7 then 300mg TDS thereafter.

04.08.01 Gabapentin 

100mg, 300mg & 400mg Capsules

For enteral tube administration the capsules can be opened and dissolved in water immediately before administration

May be prescribed generically

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and countersigned in order to fulfill the legal requirements of controlled drug prescriptions.

04.07.03 Gabapentin 250mg/ 5mL 

Restricted - for adult patients with swallowing difficulties or Paediatric patients only.

For enteral tube administration - open the capsule, dissolve the contents in water, and give immediately.

04.08.01 Gabapentin 250mg/5mL 

For paediatric patients or adults with swallowing difficulties

For enteral tube administration the capsules can be opened and dissolved in water immediately before administration

May be prescribed generically

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and countersigned in order to fulfill the legal requirements of controlled drug prescriptions. N.B pack size is 150mL, please order in full bottle quantities.

17 Gadobutrol Gadovist®

Bedford Hospital only

17 Gadoteric Acid Dotarem®

Bedford Hospital only

17 Gadoxetate disodium Primovist®
04.11 Galantamine  8mg Tablets
8mg, 16mg & 24mg Modified release capsules

Restricted to prescribing by Consultant Psychiatrists, Neurologists and physicians specialising in the care of the elderly, with continuation by GPs, in accordance with NICE TA217.
04.11 Galantamine  4mg/1mL oral solution.

Restricted - to patients who cannot swallow ordinary tablets AND
Restricted to prescribing by Consultant Psychiatrists, Neurologists and physicians specialising in the care of the elderly, with continuation by GPs, in accordance with NICE TA217.

N.B. Much more expensive than tablets / capsules.
11.03.03 Ganciclovir 0.15% ophthalmic gel Virgan®
05.03.02.02 Ganciclovir 500mg Cymevene® Restricted - must be initiated by GUM or Microbiology consultants
Not NHS Commissioned by NHS England for cytomegalovirus infection according to Trust guidelines
01.01.02 Gaviscon Advance 

Contains 2.3mmol sodium and 1mmol potassium per 5mL
Low sodium option

Hospital contract brand choice.

Not to be prescribed in Primary care.

01.01.02 Gaviscon Infant  Contains 0.9mmol sodium per dose
NOTE: each half of the dual-sachet is identified as 'one dose'. To avoid errors prescribe with directions in terms of 'dose'
08.01.05 Gefitinib Iressa® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
250mg Film Coated Tablets

Approved in accordance with NICE TA192 for the treatment of locally advanced or metastatic non-small-cell lung cancer.
09.02.02.02 Gelatin 4% Infusion 

L&D hospital: Gelaspan

Bedford hospital: Volplex

08.01.03 Gemcitabine Gemzar® 1g Injection
750mg - 2500mg in 0.9% Sodium Chloride Infusion (250mL)

Approved in accordance with NICE TA116, TA25 & TA476 for the treatment of metastatic breast cancer and pancreatic cancer.
07.01.01 Gemeprost  1mg Pessaries
Should be stored in freezer and allowed to warm up to room temperature for 30 minutes before use.
08.02.03 Gemtuzumab Mylotarg®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA545.

11.03.01 Gentamicin 

0.3% Eye /ear Drops

12.01.01 Gentamicin 0.3%  Eye / ear drops
05.01.04 Gentamicin 20mg/2mL, 80mg/2mL 

ADULTS: Once daily dose - 7mg/kg infused in 100ml of NaCl 0.9% or Glucose 5% over 60 minutes (max 560mg). Use dose determining weight in obese patients (those 20% over ideal body weight).

Take a blood sample 6-14 hours after 1st dose and twice weekly thereafter.

Multiple daily dosing for endocarditis only: 1mg/kg IV 12 hourly. See protocol.

Refer to Antimicrobial guidelines for further information.

11.03.01 Gentamicin single use 0.5% Minims® Gentamicin Sulphate To be used for patients allergic to preservatives where drops needed.
08.02.04 Glatiramer Acetate 20mg/1mL & 40mg/1mL Copaxone®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - prescribing by Consultant Neurologists and clinical nurse specialists (MS) according to NICE TA527.



05.03.03.02 Glecaprevir & Pibrentasvir 100mg/ 40mg Maviret® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted - to be initiated only by a Consultant Gastroenterologist/Hepatologist in accordance with NHS England funding requirements.
06.01.02.01 Glibenclamide 2.5mg, 5mg 

Restricted - New Patients are not to be started on this medication due to long half life and risk of hypoglycemia

06.01.02.01 Gliclazide 40mg, 80mg 

First choice sulphonylurea


06.01.02.01 Gliclazide MR 30mg, 60mg 
06.01.02.01 Glimepiride 1mg, 2mg, 3mg, 4mg 
06.01.04 Glucagon  1mg Injection
18 Glucagon 1mg GlucaGen® Hypokit

Toxicity with beta-blockers (beta-adrenoreceptor blockers)
Other indications eg. calcium channel blockers, seek NPIS advice.

L&D - Kept in ED fridge, Pharmacy EDC fridge and ITU fridge.

BHT - Kept in Accident & Emergency, AAU and various other wards (Fridge)

06.01.01.03 GlucoRx Fine point pen needles ® 

4mm/31 gauge 5 mm/31 gauge 6 mm/31 gauge

For prescribing in primary care

06.01.04 Glucose 40% Oral Gel  GlucoBoost® Restricted - for patients unable to swallow GlucoJUICE or sugar in water.
25g oral gel
09.02.02.01 Glucose Intravenous  5, 10, 20% various sizes
50% INJECTION
01.06.02 Glycerol (Glycerin)  4g, 2g & 1g suppositories


02.06.01 Glyceryl Trinitrate 

400micrograms per metered dose sublingual spray
500micrograms sublingual tablets

01.07.04 Glyceryl Trinitrate 0.4% Rectogesic® Ointment
15.01.03 Glycopyrronium  200microgram/1mL Injection
600microgram/3mL Injection
01.02 Glycopyrronium 320microgram/ mL Sialanar®

Licensed in paediatric patients only. 

For the treatment of severe sialorrhoea (chronic pathological drooling) in children and adolescents aged 3 years and older with chronic neurological disorders.

Each mL contains 400micrograms glycopyrronium bromide equivalent to 320micrograms glycopyrronium (5mL contains 2mg glycopyrronium bromide).

Note dosing is based on glycopyrronium not glycopyrronium bromide (as BNFC). For dosing instructions - refer to the table in the SPC.

01.02 Glycopyrronium bromide 1mg/ 5mL 

Licensed for use in adults only.  Used off-label for the management of hypersalivation.

01.05.03 Golimumab  FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted to prescribing by NICE criteria or by approved individual funding request (IFR) ONLY.

50mg Pre-filled Pen
50mg Pre-filled Syringe
10.01.03 Golimumab 50mg, 100mg Simponi®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Must be prescribed by a Consultant Rheumatologist in accordance with NICE TA's below.

06.05.01 Gonadorelin  100microgram Injection
06.07.02 Goserelin Zoladex®

3.6mg Injection by sub-cutaneous injection every 28 days.

N.B. 10.8mg LA injection is not licensed for endometriosis or reduction of uterine myomas.

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

08.03.04.02 Goserelin 

3.6mg Injection

by sub-cutaneous injection every 28 days.

08.03.04.01 Goserelin 3.6mg Zoladex®




05.02.05 Griseofulvin 

125mg Tablets
125mg/5mL Suspension

Restricted to Paediatrics and Dermatology. Microbiology approval required for all other uses.

Not to be prescribed for the treatment of Fungal Nail Infections

04.04 Guanfacine Intuniv®

Follow shared care guidance

13.05.02 Guselkumab Tremfya®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Prescribing by Dermatologist in accordance with NICE TA521.

14.04 Haemophilus Influenzae type B combined Vaccine Menitorix
04.02.01 Haloperidol  

Available as 5mg in 5mL and 10mg in 5mL.

04.02.01 Haloperidol 

1.5mg, 5mg & 10mg Tablets
500microgram Capsules

04.02.02 Haloperidol 50mg/1mL, 100mg/1mL 

Specialist initiation and continuation

04.02.01 Haloperidol 5mg/1mL 

NOTE: Intravenous use is now an unlicensed use. All IV use restricted to Critical Care areas only.

Initiation in Primary Care for palliative care only

02.08.01 Heparin sodium  1,000 Units In Sodium Chloride 0.9% (500ml) Intravenous Infusion

1,000 Units in 1mL ampoule (Preservative Free)
5,000 Units in 5mL ampoule (Preservative Free)
10,000 Units in 10ml ampoule (Preservative Free)

5,000 units in 5ml ampoule (Contains Preservatives)
25,000 Units in 5mL ampoule (Contains Preservatives)
02.08.01 Heparin sodium 200units / 2mL Canusal® Not for routine flushing - use sodium chloride 0.9%.

For maintaining intravenous catheters when recommended by vascular access nurse.
02.08.01 Heparin sodium 50units/5mL Hepsal®

Not for routine flushing - use sodium chloride 0.9%.

For maintaining intravenous catheters when recommended by vascular access nurse.

14.04 Hepatitis A vaccine 
14.04 Hepatitis A vaccine with Hepatitis B vaccine  Twinrix®

Primary care: This vaccine should not be prescribed on the NHS exclusively for the purposes of travel. These vaccine should continue to be recommended for travel but the individual traveller will need to bear the cost of the vaccination.

For travellers requiring both components it is recommended that the single Hepatitis A vaccine can be given on the NHS, but the Hepatitis B vaccine must be provided privately.
  

14.05.02 Hepatitis B immunoglobulin HBIG

Only to be prescribed on the advice of a consultant Microbiologist.

N.B. The leaflet states a nominal strength of 100 units/mL BUT the actual strength of each batch will be overlabelled on the vial and is probably different (since this is a biological product). All vials contain 500 units but the volume may differ. Carefully read the overlabel on each vial.

14.04 Hepatitis B vaccine Engerix B®

20microgram/1mL Injection
10microgram/0.5mL Injection - Paediatrics

Primary care: This vaccine should not be prescribed on the NHS exclusively for the purposes of travel. These vaccines should continue to be recommended for travel but the individual traveller will need to bear the cost of the vaccination.

14.04 Hepatitis B vaccine Single Component HBvaxPRO®

10microgram/1mL Injection

Primary care: This vaccine should not be prescribed on the NHS exclusively for the purposes of travel. These vaccines should continue to be recommended for travel but the individual traveller will need to bear the cost of the vaccination.

A5.03.01 Honey Dressing Algivon Plus®

10cm x 10cm Dressing
5cm x 5cm Dressing

Refer to Wound Management Formulary or TVN for appropriate use.

A5.03.01 Honey Dressing Actilite® 10cm x 10cm Dressing
10cm x 20cm Dressing
5cm x 5cm Dressing

Refer to Wound Management Formulary or TVN for appropriate use.
A5.03.01 Honey Dressing Algivon® 10cm x 10cm Dressing
5cm x 5cm Dressing

Refer to Wound Management Formulary or TVN for appropriate use.
14.04 Human Papilloma virus Vaccine Gardasil®
10.03.01 Hyaluronidase 1500units Hyalase®
02.05.01 Hydralazine  20mg Injection
02.05.01 Hydralazine  25mg Tablets
01.05.02 Hydrocortisone Colifoam® Foam enema 10% (14 doses)
• Each dose administers 125mg of hydrocortisone acetate
06.03.02 Hydrocortisone  10mg & 20mg Tablets
13.04 Hydrocortisone 0.5% / chlorhexidine 1%/ Nystatin Generic

Mild

Formerly Nystaform-HC®. Must prescribe generically.

13.04 Hydrocortisone 0.5%, 1% & 2.5%  

Mild

13.04 Hydrocortisone 1% with Clotrimazole 1% Canesten HC®

Mild

13.04 Hydrocortisone 1% with Miconazole Nitrate 2% Daktacort®

Mild

13.04 Hydrocortisone Acetate 1% with Fusidic Acid 2% Fucidin H®

Mild

12.01.01 Hydrocortisone Acetate 1% with Gentamicin 0.3% Gentisone® HC
10.01.02.02 Hydrocortisone acetate 25mg/1mL 
06.03.02 Hydrocortisone sodium phosphate 

100mg/1mL, 500mg/5mL Injection (ready diluted solution)
For emergency trays (100mg).
Glass ampoules, latex-free.

06.03.02 Hydrocortisone sodium succinate 

100mg Injection (powder for reconstitution)

Stock on most wards. First-line hydrocortisone injection.

13.11.06 Hydrogen Peroxide Crystacide®

For the treatment of impetigo in line with NICE guidelines

12.03.04 Hydrogen Peroxide 3%  In primary care prescribe 1.5% (Peroxyl®) to avoid being charged as a pharmaceutical special
13.11.06 Hydrogen Peroxide Solution BP 

3% Solution

09.01.02 Hydroxocobalamin  1mg/1mL Injection
18 Hydroxocobalamin Cyanokit®

For cyanide poisoning (smoke inhalation).

L&D - Kept in ED antidote cupboard.

BHT - Kept in Accident & Emergency

08.01.05 Hydroxycarbamide  100mg Film Coated Tablets
300mg & 500mg Capsules
500mg/5mL Liquid

10.01.03 Hydroxychloroquine 200mg  See JPC shared care guidelines.
03.04.01 Hydroxyzine (Oral)  10mg & 25mg Tablets
10mg in 5mL Syrup

Following concerns over the risk of possible cardiovascular adverse effects, the European Medicines Agency's (EMA) PRAC has completed a review of, and issued guidance on, medicines containing hydroxyzine. See links below:
01.02 Hyoscine Butylbromide 10mg 
01.02 Hyoscine Butylbromide 20mg/mL 
04.06 Hyoscine Hydrobromide  300microgram Tablets
1.5mg Patches (72 hour patch) - releases 1mg hyoscine/72 hours
15.01.03 Hyoscine Hydrobromide  400microgram/1mL Injection
11.08.01 Hypromellose 0.3%  First choice ocular lubricant
11.08.01 Hypromellose 0.3%  Restricted to patients who are allergic to preservatives.

Single use, preservative-free (Minims)
06.06.02 Ibandronic Acid 50mg 

Restricted - initiation by Consultant Oncologists with continuation by GPs for adjuvant treatment in early breast cancer.

08.01.05 Ibrutinib 140mg Imbruvica®

Blueteq or High cost drug form required – see link from Formulary homepage.

To be prescribed by Haematologists in line with NICE TA's below.

10.01.01 Ibuprofen  First choice NSAID
200mg & 400mg Tablets
100mg/5mL Sugar-free Suspension

07.01.01.01 Ibuprofen 10mg/ 2mL Pedea® injection SCBU patients only for closure of PDA.
10.03.02 Ibuprofen gel 5%, 10%  In Primary care may be cheaper for patient to purchase than pay prescription charge.
02.08 Idarucizumab Praxbind® Restricted - Prescribing on the recommendation of a consultant Haematologist only, for rapid reversal of dabigatran in life-threatening or uncontrolled bleeding or for emergency surgery/urgent procedures.

It is not suitable for use in over-anticoagulation caused by rivaroxaban, apixaban or edoxaban.

Currently one dose (2 vials) held in the Emergency Department fridge (antidote tray).

One further dose (2 vials) is also kept in the Pharmacy Emergency Drug Cupboard fridge.
08.01.05 Idelalisib Zydelig® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
100mg Tablets

Approved in accordance with NICE TA359 for the treatment of chronic lymphocytic leukaemia

Restricted - must only be prescribed by staff with specialist training in Oncology or Haematology
02.05.01 Iloprost injection  

High Cost Medicine for tertiary specialist centres only.

Bedford Hospital is a tertiary specialist centre for vascular patients.

N.B. Can prescribe at the L&D if tertiary centre approved. No stock is kept at L&D.

08.01.05 Imatinib Gilvec® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
100mg & 400mg Tablets

Approved in accordance with the NICE TA's below.

Restricted - must only be prescribed by staff with specialist training in Oncology or Haematology
04.03.01 Imipramine 10mg, 25mg 

For initiation by Mental Health specialist from ELFT only. 

13.07 Imiquimod 5% Aldara®

Restricted - Only to be prescribed by a clinician who is experienced in its use.

14.04 Inactivated Influenza Vaccine (Split Virion)  In secondary care the brand is selected each September to meet DoH guidelines. Occupational Health run an immunisation programme for staff each winter
02.02.01 Indapamide  1st choice Thiazide diuretic in the treatment of hypertension
2.5mg Tablets
1.5mg Modified-Release Tablets
10.01.01 Indometacin 

25mg Capsules
75mg Sustained Release Capsules
100mg Suppositories

1st choice treatment of acute attacks of gout. Also used in ankylosing spondylitis

01.05.03 Infliximab Remicade® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted to prescribing by NICE criteria or by approved individual funding request (IFR) ONLY.

01.05.03 Infliximab Remsima® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted to prescribing by NICE criteria or by approved individual funding request (IFR) ONLY.

13.05.03 Infliximab Remicade® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA134 for the treatment of plaque psoriasis.

10.01.03 Infliximab 100mg Remsima®, Remicade® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Must be prescribed by a Rheumatology Consultant in accordance with NICE TA195, TA199, TA375 & TA383 for the treatment of rheumatoid arthiritis and severe active ankylosing spondylitis.
NOTE:
ALL prescribing of infliximab must be by brand name.
Remsima® is first choice infliximab biosimilar for all new patients.
Infliximab biosimilar may be prescribed for patients currently receiving Remicade® brand when considered clinically appropriate by the relevant consultant and with consent of the patient

See Section 1.5.3 (for Gastroenterology) and 13.5.3 (for Dermatology)
13.08.01 Ingenol mebutate Picato®

The Marketing Authorisation for Picato has been suspended whilst the concerns on the possible risk of skin malignancy are investigated.

08.02.03 Inotuzumab Besponsa®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA541.

06.01.01.01 Insulin Aspart  Novorapid® NovoRapid® (10mL vial, 3mL cartridge)
NovoRapid® FlexPen prefilled disposable injection device.
06.01.01.01 Insulin Aspart® Fiasp NOTE: Prescribe all insulins by brand
Fiasp® (10mL vial)
Fiasp® Penfill (3mL cartridge)
Fiasp® FlexTouch (3mL prefilled pen)
Fiasp® is a new formulation of insulin aspart with a much faster onset of action. It can be given 2 minutes before a meal instead of the 20 minutes required for current fast acting insulins.
For patients with a rapid post-prandial rise in BG:
· Type 1 on CSII pump
· Type 1 on basal bolus needing tight control or has rapid post-meal blood glucose rise
· Pregnant women with diabetes
06.01.01.02 Insulin degludec  Tresiba® (3mL cartridge, 3mL FlexTouch prefilled disposable injection device)

Restricted - initiation by Consultant Diabetologists
06.01.01.02 Insulin Detemir  Levemir® (3mL cartridge, 3mL FlexPen prefilled disposable injection device)
06.01.01.02 Insulin Glargine Lantus®

Lantus® (10mL vial, 3mL cartridge)
Lantus® Solostar 3mL prefilled disposable injection device.

06.01.01.02 Insulin Glargine (Toujeo) 

Initiation by Specialist Diabetes team

Toujeo 300 units/ml (1.5mL) SoloStar, Toujeo 300 units/ml (3mL) DoubleStar pre-filled pen.

N.B. the dose increment for Solostar is 1 unit and the dose increment for Doublestar is 2 units.

Insulin glargine 100 units/ml and Toujeo are not bioequivalent and are not directly interchangeable

06.01.01.01 Insulin Glulisine  Apidra® (10mL vial, 3mL cartridge)
Apidra® Solostar (3mL prefilled disposable injection device)

06.01.01.01 Insulin Lispro   Humalog® (10mL vial, 3mL cartridge)
Humalog® KwikPen (3mL prefilled disposable injection device)
06.01.01.01 Insulin Lispro  200 units/ml

Humalog® KwikPen (3mL prefilled disposable injection device)

Specialist Diabetes Team initiation in adult patients requiring a minimum of 40 units of insulin per dose.

 

06.01.01.01 Insulin Lispro 100 units/ml 

Humalog® Junior Kwikpen For use in young children who need dosing in 0.5 unit increments.

06.01.01.01 Insulin soluble (HUMAN)  Actrapid® (10mL vial)
Humulin S® (10mL vial, 3mL cartridge)
06.01.01.03 Insupen Needles Pen® 

 4mm/33G, 5mm/31G 6mm/31G

For prescribing in primary care

08.02.04 Interferon Alfa-2a 3 millionUnits/0.5mL Roferon-A®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage


Available to Haematology only

08.02.04 Interferon Beta Rebif®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - prescribing by Consultant Neurologists and clinical nurse specialists (MS)

08.02.04 Interferon beta Extavia®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - prescribing by Consultant Neurologists and clinical nurse specialists (MS) according to NICE TA527.

08.02.04 Interferon Beta 300mcg Betaferon®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted - prescribing by Consultant Neurologists and clinical nurse specialists (MS).

07.03.04 Intra-uterine Contraceptive Devices TT 380 Slimline® Restricted - for Luton sexual Health Clinic only
07.03.04 Intra-uterine Contraceptive Devices TT 380 Slimline Mini® Restricted - for Luton sexual Health Clinic only
07.03.04 Intra-uterine Contraceptive Devices Nova-T® 360
07.03.04 Intra-uterine Contraceptive Devices T-Safe® CU 380 A
07.03.02.03 Intra-uterine Progestogen Only System Mirena® Releasing levonorgestrel 20micrograms/24hours.

Restricted - to Family Planning (Luton Sexual Health Clinic) and Obs & Gynae Consultants/SPRs only.
Levonorgestrel releasing IUDs should be prescribed by brand name.
07.03.02.03 Intra-uterine Progestogen Only System Levosert®
Releasing levonorgestrel 20micrograms/24hours.

Restricted to Obs & Gynae Consultants/SPRs only.
Levonorgestrel releasing IUDs should be prescribed by brand name.
07.03.02.03 Intra-uterine Progestogen Only System Jaydess® 13.5 mg intrauterine delivery system.

Restricted - for Luton Sexual Health Clinic only.
Levonorgestrol-releasing IUDs should be prescribed by brand name.
06.02.02 Iodine and Iodide  unlicensedunlicensed

5% aqueous iodine Oral Solution (Lugol's Iodine)x 50mL
A5.03.02 Iodoflex  For use when recommended by TVN. First choice iodine dressing.
17 Iohexol Omnipaque®
17 Iopamidol  Gastromiro®
08.01.05 Ipilimumab Yervoy® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - prescribing by Consultant Oncologists in accordance with NICE TA268, NICE TA319 or NICE TA400.
03.01.02 Ipratropium 20 microgram 

Short-acting antimuscarinic

 

03.01.02 Ipratropium 250mcg, 500mcg 

Short-acting antimuscarinic

12.02.02 Ipratropium Bromide 21micrograms per metered dose Rinatec®
02.05.05.02 Irbesartan  75mg, 150mg & 300mg Tablets
08.01.05 Irinotecan Hydrochloride  Restricted - must be prescribed only by staff with specialist training in Oncology in line with NICE guidelines.
09.01.01.02 Iron Dextran CosmoFer®

100mg/2mL & 500mg/10mL Injection
There are Trust guidelines for Obstetric patients on the Intranet.
Pharmacy will check dosing calculation and complete an administration sheet.

09.01.01.02 Iron Isomaltoside Monofer® Approved for adult IBD patients only. Must be prescribed by a specialist in Gastroenterology on the Evolve semi-smart form attached below (combined prescription and administration sheet).
09.01.01.02 Iron Sucrose Venofer®
04.03.02 Isocarboxazid 

Restricted use in Mental Health Trust

15.01.02 Isoflurane 
05.01.09 Isoniazid 50mg, 100mg  
05.01.09 Isoniazid 50mg/2mL  Restricted - Microbiology or Consultant approval required.
unlicensedunlicensed
05.01.09 Isoniazid 50mg/5ml  

Red unlicensed Unlicensed isoniazid 50mg/5ml liquid available for paediatric patients on advice of Specialist Tuberculosis Clinic when tablets are not suitable

Restricted - Microbiology or Consultant approval required.

06.01.01.02 Isophane Insulin (HUMAN)  Insulatard® (10mL vial, 3mL cartridge)
Insulatard® InnoLet prefilled disposable injection device)
Humulin® I (10mL vial, 3mL cartridge)
Humulin® I-Pen prefilled disposable injection device.
Insuman Basal® (10mL vial, 3mL cartridge)
Insuman Basal® (pre-filled pen)

02.07.01 Isoprenaline  0.2mg in 1mL Injection
02.06.01 Isosorbide Dinitrate 

10mg & 20mg Tablets
40mg Sustained Release Tablets

Note: much more expensive than isosorbide mononitrate which is preferred. 10 and 20mg dinitrate much more expensive than 40mg SR tablets. Consider switch to isosorbide mononitrate.
No new initiations.

02.06.01 Isosorbide Dinitrate 

0.05% Injection (50mL)- ready diluted

10mg in 10mL (0.1%) Injection - For Cardiac Centre only.

02.06.01 Isosorbide Mononitrate 

10mg & 20mg Tablets

When prescribing, ensure an 8 hour nitrate free period is accounted for to reduce the risk of developing nitrate tolerance. Usually prescribe at 8am and 12pm (or 2pm).

02.06.01 Isosorbide Mononitrate MR 

25mg, 40mg, 60mg (various brands).

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise

 

13.06.02 Isotretinoin  5mg, 10mg & 20mg Capsules

For use by the Dermatology specialists only
13.06.01 Isotretinoin with erythromycin Isotrexin®
01.06.01 Ispaghula Husk  Granules
05.02.01 Itraconazole 

100mg Capsules
10mg/1mL Oral Liquid

Restricted - Haematology, Oncology and GUM. Microbiology approval required for all other uses.

 

02.06.03 Ivabradine 5mg & 7.5mg   Restricted - to be initiated by consultant Cardiologist in accordance with NICE TA 267

Tablets can be split.
13.10.04 Ivermectin 3mg 

unlicensed unlicensed

Restricted - to be prescribed by specialists for crusted or Norwegian scabies only.

08.01.05 Ixazomib Ninlaro®

Funding approval required.

Funded by Cancer Drug Fund when prescribed  with lenalidomide and dexamethasone for the treatment of multiple myeloma by Oncologist according to NICE TA505.

13.05.03 Ixekizumab 80mg Taltz®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
To be prescribed by specialists in accordance with NICE TA442 and TA537.

13.08.02 Keromask® 

Masking Cream

Prior to prescribing, self-care options should be considered.
If NHS Prescribing is required, the following recommendations apply:-
 The prescribing of camouflage creams by clinicians is only supported if the patient has a disfiguring facial condition that is causing distress, impacting in a restrictive way on the patient’s life.
Prior to prescribing:-
 The patient should be referred to a Secondary Care Specialist for advice on optimal management and investigation of any underlying cause.
 The patient should be referred to a trained skin camouflage practitioner for colour matching.

A5.03.03 Kerracontact Ag  

5cm x 5cm 
10cm x 12.5cm 
15cm x 15cm 


Refer to Wound Management Formulary or TVN for appropriate use.

A5.02.01 Kerralite Cool   12cm x 8.5cm Dressing (Non Adhesive)
6cm x 6cm Dressing (Non Adhesive)
11cm x 11cm (Adhesive)

Refer to Wound Management Formulary or TVN for appropriate use.
04.07.03 Ketamine 50mg/5ml oral solution 

Shared care with Hospice only in adults in palliative care.

 Red For the treatment of neuropathic pain in inpatients under supervision of pain team at Bedford Hospital only

15.01.01 Ketamine injection  500mg/10mL, 200mg/ 20mL Injection

13.09 Ketoconazole 

2% Shampoo

Can be purchased OTC - self-care in primary care

13.10.02 Ketoconazole 2% 
15.01.04.02 Ketorolac  30mg/1mL Injection
11.08.02 Ketorolac 5mg/mL Acular®

Safety Alert from Moorfield's Hospital (February 2016)

There have been recent cases in which patients have suffered severe corneal melting following the combined use of acular and maxitrol (dexamethasone and neomycin) after routine cataract surgery. This is a very rare but recognised complication of acular use but it appears that the combination of the two preparations together may significantly increase the risk of corneal melting.

  • Do not prescribe acular in combination with maxitrol for any patient
  • Do not use maxitrol routinely for post phaco medication. Follow cataract service guidelines using dexamethasone and chloramphenicol
  • Be aware that the use of acular is associated rarely with corneal melts and the risk is increased in diabetics and immunocompromised patients
  • Be vigilant for any corneal melts associated with maxitrol and acular and report them as an incident
02.04 Labetalol  50mg, 100mg & 200mg Tablets
02.04 Labetalol  100mg in 20mL Injection
01.06.04 Lactulose  Solution
05.03.01 Lamivudine  Restricted - must be prescribed by HIV consultants only

100mg, 150mg & 300mg Tablets
100mg Film Coated Tablets
10mg/1mL Solution
04.02.03 Lamotrigine 

For specialist initiation in the treatment of bipolar disorder

04.08.01 Lamotrigine 

25mg, 50mg & 100mg Tablets
5mg, 25mg & 100mg Soluble Tablets

Prescribing generically or by brand is discretionary.

03.04.03 Lanadelumab  Takhzyro®

FOR ALL PRESCRIBING - Blueteq or High Cost Drug Form required - see link from Formulary homepage.

Restricted prescribing in accordance with the following NICE TA(s):-

08.03.04.03 Lanreotide Somatuline Autogel®

Funded by NHS England for certain licensed indications. Contact the Commissioning Pharmacist for all prescribing.

08.03.04.03 Lanreotide 30mg Somatuline® LA

Funded by NHS England for certain licensed indications. Contact the Commissioning Pharmacist for all prescribing.

01.03.05 Lansoprazole 15mg, 30mg 

RESTRICTED to patients with swallowing difficulties.

See Joint Guidance on Lansoprazole formulation in Children (January 2017) for further information on dosing and suitable formulations in children.

Children with a naso-gastric tube (<8Fr) or a PEG tube prescribed doses that are not a suitable proportion of an orodispersible tablet should be prescribed Sodium Bicarbonate 1mmol/ml oral solution to dissolve the lansoprazole, see the Joint guidance for further information.

01.03.05 Lansoprazole 15mg, 30mg 
09.05.02.02 Lanthanum Fosrenol ®

For patients with swallowing difficulties.

See shared care guidance.

09.05.02.02 Lanthanum Fosrenol ®

See shared care guidance

09.08.01 L-Arginine 5g /10mL 

For paediatric patients.

Kept in the L&D Pharmacy EDC for use prior to patient transfer to specialist hospital.

08.01.05 Larotrectinib  Vitrakvi®

 

FOR ALL PRESCRIBING - Blueteq or High Cost drug form required - see link from Formulary homepage.

Restricted use in accordance with the following NICE TA as part of the Cancer Drugs Fund

A5.04 Larvae therapy  Various sizes.
Restricted to recommendation by TVN only. Order by 2pm for next day delivery.
15.02 LAT   LAT Gel

Restricted - To be used prior to suturing of wounds in children only
11.06 Latanoprost  50microgram/1mL Eye Drops
1st Choice prostaglandin analogue eye drops
N.B. Must prescribe generically on FP10.
11.06 Latanoprost with Timolol  Latanoprost 0.005%/Timolol 0.5% Eye Drops

N.B. Must prescribe generically on FP10.
05.03.03.02 Ledipasvir and Sofosbuvir 400mg/ 90mg Harvoni® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - to be initiated only by a Consultant Gastroenterologist/Hepatologist in accordance with NICE TA363 for the treatment of chronic hepatitis C.

10.01.03 Leflunomide  10mg & 20mg Tablets

Restricted- must be initiated by a Rheumatology consultant. See JPC shared care guidelines.
08.02.04 Lenalidomide 

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

5mg, 10mg, 15mg & 25mg Capsules

Approved for specialist prescribing in accordance with NICE TA's below. 


09.01.06 Lenograstim Granocyte®

Consultant recommendation only 
13.4 million-units (105 micrograms)
33.6 million-units (263 micrograms)

08.01.05 Lenvatinib Lenvima®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Prescribing by specialist in line with the NICE TA's below.

05.03 Letermovir Prevymis®

Restricted - must be prescribed in accordance with the following NICE TA(s):

06.05.01 Letrozole 2.5mg  Approved by DTC for the off-label indication of ovulation induction in women with polycystic ovary syndrome. Dose 2.5 to 5mg once daily from days 2 to 6 of the menstrual cycle for up to 6 months. For hospital prescribing in the fertility clinic only.
08.03.04.01 Letrozole 2.5mg 

For breast cancer

06.07.02 Leuprorelin Prostap®

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

04.08.01 Levetiracetam 

250mg, 500mg & 1g Tablets
100mg/1mL Solution - N.B. risk of medication errors (overdose) in children. Always prescribe dose in milligrams.

May be prescribed generically.

04.08.01 Levetiracetam  100mg/1mL Injection

May be prescribed generically
15.02 Levobupivacaine Chirocaine® For use in theatres for selected nerve block procedures.
09.08.01 Levocarnitine 30%  

NHSE funded for carnitine deficiency.

05.01.12 Levofloxacin  500mg/100mL IV Infusion

These must only be prescribed in accordance with the approved indications for use listed in Luton & Dunstable Trust's antimicrobial guideline or by recommendation from the Consultant Microbiologist.

Oral bioavilability is >90%. The dosing for IV preparation and oral preparation is equivalent. Early switch to oral therapy is encouraged.
05.01.12 Levofloxacin  250mg & 500mg Tablets

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.

Oral bioavilability is >90%. The dose for IV and oral preparations is equivalent. Early switch to oral therapy is encouraged.
11.03.01 Levofloxacin  0.5% Eye drops
0.5% Preservative-free single dose eye drops (Minims)- only for patients allergic to preservative.
04.02.01 Levomepromazine 

25mg Tablets

Initiation in Primary Care for palliative care only

04.02.01 Levomepromazine 

25mg/1mL Injection

Initiation in Primary Care for palliative care only

07.03.05 Levonorgestrel 1.5mg  Restricted - for Luton Sexual Health Clinic only.

In primary care may also be purchased over the counter.
06.02.01 Levothyroxine  25microgram, 50microgram & 100microgram Tablets
06.02.01 Levothyroxine 

unlicensedunlicensed. 200micrograms/ml injection.

Please note this is a different brand to the one listed in the Medusa IVGUIDE. Follow the attached dose conversion  and administration guide.


Restricted: for patients who are NBM for a prolonged period. Half-life is very long (about 7 days) so replacement is often not needed in the short-term.
To be prescribed on the recommendation of a consultant endocrinologist only.

06.02.01 Levothyroxine 50micrograms/ 5mL 
02.03.02 Lidocaine  1% in 5mL, 10mL & 20mL Vial
2% in 5mL Vial
15.02 Lidocaine   0.5% & 1% Injection (10mL)
1% & 2% Injection (5mL)
1% Injection Ampoule

15.02 Lidocaine 10% laryngojet® 10mg/dose
15.02 Lidocaine 2.5% with Prilocaine 2.5% EMLA®
13.03 Lidocaine 5% 
15.02 Lidocaine 5% and Phenylephrine 0.5% 
15.02 Lidocaine 5% Plaster Versatis®

Restricted - Must be initiated  only for the licensed indication: post herpetic neuralgia,  in line with the JPC guideline.

The evidence for the effectiveness of lidocaine medicated plasters is limited, of low quality, and the clinical effectiveness remains unclear. However, low quality individual studies indicate that it may have a role in pain relief.

Response to treatment should be evaluated after 4 weeks of treatment. Patients with an inadequate initial response after 4 weeks, (improvement after this time is unlikely) – DISCONTINUE treatment.

The therapeutic benefit should be reassessed regularly at least every three months.

The DTC previously approved for palliative patients for neuropathic pain where systemic treatment is not tolerated. This indication is under review.

11.07 Lidocaine Hydrochloride 4% with Fluorescein 0.25% Minims®
15.02 Lidocaine with Adrenaline (1% / 1:200,000) 
15.02 Lidocaine2% with Chlorhexidine 0.25%  Brands include Instillagel.

N.B. Available from Main Stores (not Pharmacy).
01.06.07 Linaclotide Constella▼® Restricted unless in line with JPC guidelines

The use of linaclotide for the symptomatic treatment of severe irritable bowel syndrome with constipation (IBS-C) is supported as a treatment option after an unsuccessful trial of conventional laxatives. (Check diet and compliance with conventional laxatives). Patients must have a confirmed diagnosis of IBS-C prior to treatment with linaclotide.

290mg capsules
06.01.02.03 Linagliptin  5mg Film Coated Tablets
05.01.07 Linezolid 100mg/5mL 

Restricted - Microbiology or Consultant approval required.
Restricted to paediatric patients or adults with swallowing difficulties. N.B. generic product not available for the suspension which is nearly £300 per bottle.

GPs can prescribe linezolid under the specialist direction of a Consultant Microbiologist only, in order to prevent a hospital admission.

For all hospital initiated treatment the it should be considered 'hospital only' and the full course should be prescribed in secondary care and not transferred to GP

05.01.07 Linezolid 600mg  

Restricted - Microbiology or Consultant Approval required.
Oral bioavailability is 100%. The oral route should be used where possible.

N.B. Do not prescribe on FP10. All prescriptions to be dispensed by the hospital Pharmacy. Costs on FP10 around £340 for 10 tablets.

GPs can prescribe linezolid under the specialist direction of a Consultant Microbiologist only, in order to prevent a hospital admission.

For all hospital initiated treatment the it should be considered 'hospital only' and the full course should be prescribed in secondary care and not transferred to GP.

05.01.07 Linezolid 600mg/300mL  Restricted - Microbiology or Consultant Approval required.
The oral bioavailability is 100% therefore prescribe orally where possible.
06.02.01 Liothyronine  20microgram Injection

Only to be used for it's licensed indication: myxoedema coma.
N.B. cost now £1710 per 5 ampoules.

Levothyroxine has a very long half life (~7 days) so temporary IV replacement if NBM is not needed unless prolonged. Unlicensed IV levothyroxine is now available for this indication.
06.02.01 Liothyronine 20microgram 

2nd-line to levothyroxine.

Please refer to attached JPC bulletin for restricted prescribing criteria. Prescribing to remain within hospital apart from rare exceptions described in the bulletin. 

N.B. now >£300 per box.

18 Lipid Rescue Kit (Intralipid) 20% 

Local anaesthetic toxicity (e.g.lidocaine, bupivacaine). Other specific drugs in overdose (advised by NPIS / Toxbase).


L&D - Kept in theatre recovery units, ED antidote cupboard, ward 23 and Pharmacy EDC.

BHT - Kept in Accident & Emergency, Upper Theatre recovery and Delivery Suite Theatre

08.01.02 Liposomal Doxorubicin Hydrochloride Caelyx® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted to be used in line with NICE TA389.

2 mg/ml concentrate for solution for infusion in a pegylated liposomal formulation.
13.02.01 Liquid and White Soft Paraffin (50:50) 
11.08.01 Liquid Paraffin eye ointment 

Primary care: Most cost effective brand to be advised via ScriptSwitch/Optimise

Hospital: brand supplied will depend on availability.

L&D: Lacri-Lube is still unavailable. We are purchasing VitA-POS ointment as a substitute but note this has changed its name to Hylo Night. Prescribe generically on ePMA as 'liquid paraffin eye ointment'.

06.01.02.03 Liraglutide 

First choice

To be initiated by a Diabetes specialist in line with NICE Guidance NG28.

6mg/1mL Injection

04.04 Lisdexamfetamine Elvanse®

Follow shared care guidance below

02.05.05.01 Lisinopril  2.5mg, 5mg, 10mg & 20mg Tablets
04.02.03 Lithium Carbonate Priadel®

This medication must be prescribed via brand name due to differences in bioavailability - alternative brands may be ordered by Pharmacy if for continuation therapy only.

200mg & 400mg Sustained Release Tablets

04.02.03 Lithium Carbonate 400mg Camcolit®

This medication must be prescribed via brand name due to differences in bioavailability - alternative brands may be ordered by Pharmacy if for continuation therapy only.

N.B The most expensive lithium brand. Priodel preferred. For continuation of treatment only.

04.02.03 Lithium Carbonate 450mg Liskonum®

This medication must be prescribed via brand name due to differences in bioavailability - alternative brands may be ordered by Pharmacy if for continuation therapy only.

04.02.03 Lithium Citrate 520mg/5mL 
14.04 Live attenuated Influenza Vaccine 

For prophylaxis of influenza in children and adolescents from 24 months to less than 18 years of age

15.02 LMX Lidocaine  Lidocaine W/W 4% Cream
11.04.02 Lodoxamide 0.1% 
04.03.01 Lofepramine 

70mg Tablets

04.10.03 Lofexidine  200microgram Tablets

For continuing treatment only. To be initiated by the Mental Health Team.
01.04.02 Loperamide  2mg Capsules
1mg/5mL syrup
01.04.02 Loperamide   2mg orodispersible tablets.
RESTRICTED: for patients with enteral tubes on high doses or those unable to take capsules or syrup e.g high output stoma patients.
05.03.01 Lopinavir and Ritonavir Kaletra® Restricted - must be prescribed by HIV consultants only

Lopinavir 100mg/Ritonavir 25mg Tablets
Lopinavir 200mg/Ritonavir 50mg Tablets
Lopinavir 400mg/Ritonavir 100mg in 5 mL Oral Solution
04.01.01 Loprazolam 

For initiation by Mental Health specialist from ELFT only

03.04.01 Loratadine 

10mg Tablets - Available to purchase over the counter
5mg in 5mL Syrup - Available to purchase over the counter

04.01.02 Lorazepam  1mg & 2.5mg Tablets
04.01.02 Lorazepam  4mg/1mL Injection
04.08.02 Lorazepam 

4mg/1mL injection

08.01.05 Lorlatinib Lorviqua®

FOR ALL PRESCRIBING - Blueteq or High cost drug form required - see link from Formulary homepage.

Approved in accordance with the following NICE TA(s):

04.01.01 Lormetazepam  For initiation by Mental Health specialist from ELFT only
02.05.05.02 Losartan  12.5mg, 25mg, 50mg & 100mg Tablets
11.04.01 Loteprednol 0.5% Lotemax®
04.02.01 Lurasidone Latuda®

Restricted use in Mental Health Trust, initiaition only by specialist Mental Health Prescribers

09.01.04 Lusutrombopag Mulpleo®

FOR ALL PRESCRIBING - Blueteq or high cost drug form required - see link from Formulary home page.

RESTRICTED to prescribing in accordance with the following NICE TA(s):

05.01.03 Lymecycline 408mg 

For dermatolgy prescribing for acne.

13.06.02 Lymecycline 408mg 

For dermatolgy prescribing for acne.

01.06.04 Macrogol oral powder 

Adult oral powder
Paediatric oral powder

Hospital Trusts: as per contract brand, prescribe generically

Primary care - prescribe Cosmocol brand

01.06.05 Macrogols Klean-Prep®

Oral powder - Bowel cleansing only

01.06.05 Macrogols Moviprep®

Oral powder - Bowel cleansing only

Bedford Hospital - during shortage please use Citramag, 2 sachets with 10 senna tablets (September 2019)

01.06.05 Macrogols Plenvu®

Alternative option to Moviprep or Klean-prep for patients unable to comply with large volume.

18 Macrogols Klean-Prep®

NOTE: Do not confuse with Movicol preparations.
Whole bowel irrigation for agents not bound by activated charcoal eg. iron, lithium, also for bodypackers and for slow release preparations.

L&D - Kept in ED antidote cupboard.

BHT - Kept on Howard ward, Reginald Hart ward and RIverbank ward

09.05.01.03 Magnesium Aspartate Magnaspartate®

243mg Sachets (10mmol Magnesium). 

N.B This is the only licensed oral magnesium salt and should be prescribed where possible from 2 years upwards.

Maximum licensed dose: 1 sachet (10mmol) twice daily

09.05.01.03 Magnesium Glycerophosphate 

unlicensedunlicensed
Tablets containing 4mmol Magnesium
Oral Liquid containing 1mmol/1mL

Restricted to use when magnesium aspartate inappropriate e.g children under 2 years and for enteral tube administration where volume too great.

N.B. tablets can be crushed and mixed with waterfor enteral tube administration.

09.05.01.03 Magnesium Sulphate 

4mmol/10mL 10% Injection
4mmol/2mL 50% Injection
20mmol/20mL 50% Injection

 

Risk of incorrect dosing/administration of magnesium sulphate injection

We have been made aware of a serious clinical incident in another Trust involving magnesium sulphate 50% (20mmol in 10mL) ampoules, 50 pack size DEMO brand.

Labelling on the front of the box gives the strength as 50% and as 20.3mmol/10mL but the labelling on the ampoule only gives the strength as 50%w/v.

This issue also applies to the magnesium sulphate 10% (4mmol in 10mL) ampoules, 10 pack size DEMO brand. The labelling on the box gives the strength as 10% w/v and as 4.06mmol/10 mL but the labelling on the ampoule only gives the strength as 10%w/v.

Pharmacy is making every effort to source from other suppliers but this has been very difficult owing to ongoing drug shortages.

Before administration, check the ampoule against the label on the front of the box to confirm the strength. Please ensure all relevant staff are made aware of this.

13.10.04 Malathion 0.5% Debra M®

For inpatient use only, not to be prescribed on TTA.

Self-care in primary care

02.02.05 Mannitol  10% & 20% 500ml Polyfusor - intravenous infusion
20 Mannitol Challenge Test Osmohale®

For use by Bedford Hospital Respiratory Physiology department

05.03.01 Maraviroc  150mg & 300mg Film Coated Tablets
Restricted - must be initiated by HIV consultants only

14.04 Measles, Mumps and Rubella Vaccine, (MMR) 
05.05.01 Mebendazole  100mg Tablets
100mg/5mL Suspension
01.02 Mebeverine Hydrochloride 135mg 

N.B. MR tablets non-formulary.

13.02.02 Medihoney® 

Primary Care: see Bedfordshire and Luton Community Wound Care Formulary http://cms.horizonsp.co.uk/viewer/sept/woundformulary

L&D hospital: for inpatient use only as barrier, not to be prescribed on TTA. Note this product is not stocked in Pharmacy - order from main stores.

06.04.01.02 Medroxyprogesterone Acetate 

5mg & 10mg Tablets

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

07.03.02.02 Medroxyprogesterone Acetate Depo-Provera® 150mg/1mL Pre-filled Syringe
07.03.02.02 Medroxyprogesterone acetate Sayana Press® 104mg subcutaneous injection every 13 weeks.

Restricted - for Luton Sexual Health Clnic only.
08.03.02 Medroxyprogesterone Acetate 100mg Provera®

For oncology

10.01.01 Mefenamic Acid 250mg  
05.04.01 Mefloquine 250mg  Lariam® Restricted - For the treatment of malaria only under specialist authorisation, but no longer recommended.

Not for malaria prophylaxis - private GP prescription needed.
08.03.02 Megestrol Acetate Megace®

100mg & 160mg Tablets

04.01.01 Melatonin  Slenyto® 1mg and 5mg prolonged release tablets. For specialist initiation and continuation
04.01.01 Melatonin 1mg/mL 

unlicensed unlicensed

Restricted: 3rd-line choice for children with tubes/those with severe swallowing difficulties where all medicines are liquids.

Restricted: Critically ill patients on ITU (see attached protocol).

04.01.01 Melatonin 2mg MR Circadin®

For children and adolescents. See Shared Care Guidelines.

Melatonin 2mg m/r tablets (Circadin®) should be used first line if the appropriate dose can be obtained by either swallowing whole or crushing into water/ soft food. It can be halved without losing modified release characteristics and crushed and mixed with water/juice/soft food for swallowing difficulties.


Please note: once crushed it will no longer be modified release.

08.01.01 Melphalan  50mg Injection

04.11 Memantine  10mg & 20mg Tablets
10mg/1mL pump actuation oral solution

Restricted to prescribing by Consultant Psychiatrists, Neurologists and physicians specialising in the care of the elderly, with continuation by GPs, in accordance with NICE TA217.
09.06.06 Menadiol Sodium Phosphate  10mg Tablets
Water soluble preparation for vitamin K and to be used in patients with hepatic disease

For ORAL treatment of elevated INR phytomenadione injection 2mg/0.2mL (Konakion MM Paediatric, licensed for this route) should be prescribed and administered via the ORAL route. For 10mg doses, the adult phytomenadione injection (10mg/mL) has been given orally. This is off-label but has been checked with the manufacturer. The formulation is the same as the paediatric konakion MM.

14.04 Meningococcal A, C, W135, and Y conjugate vaccine Menveo®

In secondary care restricted - Occupational Health & around splenectomy

14.04 Meningococcal group B Vaccine Bexsero® To be considered for splenectomy patients as per DOH Guidelines.
14.04 Meningococcal group C conjugate vaccine 
06.05.01 Menotrophin  

Also called Human Menopausal Gonadotrophins.

Contracted brands include Menopur and Meriofert. 75 units/vial can be ordered for use in hospital.

For outpatient prescribing there is a multidose vial containing 1200 units/vial and presentation inlcudes alcohol wipes, needles and disposable graduated syringes.

13.03 Menthol in aqueous cream 

Brands include Dermacool® and Menthoderm®

03.04.02 Mepolizumab Nucala®

To be prescribed by specialists according to NICE TA431.

BHT - Only to be prescribed for continuation of stable patients initiated by Cambridge Univeristy Hospital. CUH must supply their Blueteq number to BHT pharmacy to allow the cost to be reclaimed from NHS England.

04.07.02 Meptazinol Meptid® 200mg Tablets
01.05.03 Mercaptopurine 

50mg tablets

Do not crush or break tablets.

Shared Care Guidelines for inflammatory bowel disease

08.01.03 Mercaptopurine  unlicensedunlicensed 10mg Tablets
50mg Tablets
100mg/5mL Suspension

Restricted - this medication requires authorisation from a consultant before prescribing
05.01.02.02 Meropenem  500mg & 1g Injection

Must only be prescribed in accordance with the Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.

N.B. Do not prescribe concurrently with sodium valproate, valproic acid or valproate semisodium due to the major drug interaction. Valproic acid levels are reduced by 60 to 100% within 2 days.
01.05.01 Mesalazine Octasa®

400mg & 800mg MR tablets

- better value version of Asacol

Must prescribe by brand name

N.B 1600mg tablets are currently non-formulary

01.05.01 Mesalazine Asacol®

MR tablets 400mg, 800mg

Must prescribe by brand name

N.B. suppositories and foam enema discontinued.

01.05.01 Mesalazine Pentasa®

500mg SR tablets
1g & 2g prolonged release sachet
1g suppositories
1g in 100mL retention enema

Must prescribe by brand name

01.05.01 Mesalazine  Mezavant® XL

1.2g MR tablets
- once daily dosing

Must prescribe by brand name

08.01 Mesna  400mg Tablets
1g/10mL Injection
18 Mesna 1g in 10mL 

Cyclophosphamide toxicity

L&D - Kept in Pharmacy EDC.

BHT - contact Pharmacy (Oncall Pharmacist via switchboard out of hours)

13.02.02 Metanium® 

Barrier preparation.


Self-care in Primary Care (purchase OTC).

02.07.02 Metaraminol 2.5mg/ 1mL 
06.01.02.02 Metformin  500mg & 850mg Tablets
06.01.02.02 Metformin  

500mg, 750mg , 1000mg MR tablets

Restricted - in accordance with NICE NG28 -Type 2 Diabetes which recommends MR tablet for second line use after titration with metformin fails.


06.01.02.02 Metformin 

Oral solution 500mg/5mL
Restricted - to patients who cannot swallow metformin hydrochloride tablets.

Also available as 850mg/5mL and 1g/5mL in primary care. These strengths are not routinely stocked at the L&D.

04.10.03 Methadone 1mg/ 1mL 

Restricted for continuation of patients already on Methadone as part of their drug withdrawal scheme. For new patients refer to Drugs & Alcohol services.

This strength is only to be prescribed for addicts.

01.05.03 Methotrexate 

For preparations see section 10.01.03 

08.01.03 Methotrexate  7.5mg/0.15mL, 10mg/0.2mL, 12.5mg/0.25mL, 15mg/0.3mL,
17.5mg/0.35mL, 20mg/0.4mL, 22.5mg/0.45mL, 25mg/0.5mL
27.5mg/0.55mL & 30mg/0.6mL Subcutaneous Injection

10.01.03 Methotrexate  2.5mg Tablets
10mg/5mL Oral Solution

In accordance with JPC Shared Care Guidelines for inflammatory arthritis.
13.05.03 Methotrexate  See section 10.1.3
10.01.03 Methotrexate 50mg/mL Metoject® Multiple strengths available.

Restricted to Consultant Rheumatologist prescribing for inflammatory arthritis in accordance with shared care guidelines.
15.01.02 Methoxyflurane 99.9% Penthrox®

For use in single episodes of trauma in the Emergency Department only, for patients with Colles fracture or dislocation.

13.05.02 Methoxypsoralen 

5-methoxypsoralens available as:

  • 20mg tablets

8-methoxypsoralens available as:

  • 10mg tablets
  • gel
  • 1.2% bath lotion


    For dermatology use with PUVA


01.06.01 Methylcellulose 

500mg tablets

02.05.02 Methyldopa  250mg & 500mg Tablets
04.04 Methylphenidate 5mg, 10mg & 20mg 

Only to be initiated by specialist in ADHD according to NICE TA98.

Follow shared care guidance below.


04.04 Methylphenidate Hydrochloride MR 

Only to be initiated by specialist in ADHD according to NICE TA98.

Follow shared care guidance below.

Modified / extended release tablets or capsules (various brands available)

 

06.03.02 Methylprednisolone  100mg Tablet

Restricted to recommendation by consultant Neurologist
06.03.02 Methylprednisolone Acetate  40mg, 80mg, 120mg
For intramuscular, intra-articular, intrabursal, periarticular, intralesional administration or into tendon sheath.
10.01.02.02 Methylprednisolone Acetate Depo-Medrone® 40mm/1mL, 80mg/2mL & 120mg/3mL Injection
For intramuscular, intra-articular, intrabursal, periarticular, intralesional administration or into tendon sheath.
06.03.02 Methylprednisolone sodium succinate Solu-Medrone® Methylprednisolone sodium succinate
40mg (note may contain milk protein traces - see link below), 500mg, 1g & 2g Injection

for intravenous or intramuscular use only

18 Methylthioninium chloride 0.5% Proveblue®

Methaemoglobinaemia.

L&D - Kept in ED antidote cupboard and ITU.

BHT - Kept in Accident & Emergency, Upper Theatre and Delivery Suite Theatre

04.06 Metoclopramide  10mg/2mL Injection
04.06 Metoclopramide  10mg Tablets
5mg/5mL Sugar Free Solution

Dot Metoclopramide should only be prescribed for short-term use (up to 5 days)
Dot Use of metoclopramide is contraindicated in children younger than 1 year
Dot In children, age 1–18 years, metoclopramide should only be used as a second-line option for prevention of delayed chemotherapy-induced nausea and vomiting, and for treatment of established postoperative nausea and vomiting

02.02.01 Metolazone  5mg Tablets
02.04 Metoprolol  50mg Tablets
Tablets can be halved
02.04 Metoprolol  5mg in 5mL Injection
05.01.11 Metronidazole  500mg/100mL IV Infusion
05.01.11 Metronidazole  200mg & 400mg Tablets
500mg & 1g Suppositories
200mg/5mL Suspension

1st line for treatment of mild to moderate C.difficile

Oral bioavailability is approximately 80-85% with a 500mg IV dose equivalent to 400mg oral. When the oral route is inappropriate the rectal route may be used. Effective blood concentrations are achieved within 5-12 hours.
05.04.02 Metronidazole  See Section 05.01.11
13.10.01.02 Metronidazole 0.75% 
13.10.01.02 Metronidazole 0.75% gel  
06.07.03 Metyrapone  RESTRICTED USE
250mg Capsules
04.03.01 Mianserin 

For initiation by Mental Health specialist from ELFT only

01.06.04 Micolette® Sodium Citrate  Enema
12.03.02 Miconazole 2% 

Beware of drug interactions due to inhibitition of cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Miconazole is absorbed systemically from the oral gel preparation and has the potential to raise plasma levels of drugs metabolised by these isoenzymes, increasing the risk of adverse effects.

13.10.02 Miconazole 2% 
04.08.02 Midazolam Buccolam ® Must be prescribed by brand name. Start all new patients on Buccolam (as licensed).

2.5mg/0.5ml, 5mg/1 ml, 7.5mg/1.5ml & 10mg/2ml Pre-filled oral syringe.

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfill the legal requirements of a controlled drug prescriptions. e.g. Please supply two (2) syringes (signed).
04.08.02 Midazolam Epistatus® Must be prescribed by brand name

2.5mg/0.25mL, 5mg/0.5mL, 7.5mg/0.75mL & 10mg/1mL Oral pre-filled syringe
04.08.02 Midazolam  Restricted - intravenous route to be used on ITU only



15.01.04.01 Midazolam  5mg/5mL, 10mg/2mL & 10mg/2mL Injection

N.B.: always prescribe 10mg/2mL strength for palliative care.
15.01.04.01 Midazolam 10mg in 2mL Buccolam®

Approved by DTC for adult patients with severe pre-operative anxiety where alternatives cannot be given (e.g. needle phobic patients).

02.07 MIDODRINE Tablets 2.5 mg, 5mg 

BHT: Use in Paediatrics is approved for initiation by Consultant specialising in Cardiology. Transfer to GP prescribing in these patients must be preceeded by discussion between the Consultant and the GP.

08.01.05 Midostaurin 25mg Rydapt®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Prescribing by specialist in line with NICE TA523.

07.01.02 Mifepristone  200mg Tablets
02.01.02 Milrinone Primacor® For use in ITU, NICU & SCBU only
10mg in 10mL injection

07.04.02 Mirabegron 

25mg & 50mg Prolonged Release Tablets

Must fulfil criteria in NICE TA290 for the treatment of an overactive bladder.

04.03.04 Mirtazapine  15mg & 30mg Tablets
15mg, 30mg & 45mg Orodispersible Tablets
07.01.01 Misoprostol 200microgram  For non-surgical management of miscarriage (unlicensed indication). Can be given orally or vaginally following Trust guidelines.
08.01.02 Mitomycin  unlicensedunlicensed 8mg, 9mg, 10mg, 11mg, 12mg & 14mg in Sodium Chloride 0.9% Pre-filled Syringe
2mg, 20mg & 40mg Injection
0.04mg/1mL & 1.2mg/3mL Water for injection Pre-filled Syringe

08.01.02 Mitoxantrone (Mitozantrone)  25mg/12.5mL Injection
unlicensedunlicensed 9.8mg, 11mg, 13mg, 14mg, 15mg, 18mg, 20mg & 22mg in 0.9% Sodium Chloride Infusion

15.01.05 Mivacurium Chloride  10mg/5mL & 20mg/10mL Injection
04.03.02 Moclobemide 150mg, 300mg 

For initiation by Mental Health specialist from ELFT only

13.04 Mometasone Furoate 0.1% generic

Formerly Elocon® brand. Must prescribe generically.

Potent

12.02.01 Mometasone Furoate 50micrograms per metered dose 
03.03.02 Montelukast  10mg Tablets
4mg & 5mg Chewable Tablets
03.03.02 Montelukast  4mg Sachets - Restricted only for use in children who cannot manage chewable tablets
04.07.02 Morphine Sulphate 

10mg/1mL, 15mg/1mL, 30mg/1mL

100mg/50mL IV Infusion

04.07.02 Morphine Sulphate Sevredol® N.B. these are not sustained release and should be prescribed every 4 to 6 hours like Oramorph.
04.07.02 Morphine Sulphate MST Continus® 5mg, 15mg sustained release tablets
04.07.02 Morphine Sulphate 100mg/ 5mL 
04.07.02 Morphine Sulphate 10mg/ 5mL Oramorph® First choice strong opiate.
04.07.02 Morphine Sulphate MR Zomorph® 10mg, 30mg, 60mg & 100mg Sustained Release capsules

First choice strong opiate.



11.03.01 Moxifloxacin 0.5% Moxivig

Prescribing by Ophthalmologists for bacterial keratitis.

N.B. These drops do not contain benzylkonium chloride (described as self-preserved).

05.01.12 Moxifloxacin 400mg  Restricted - prescribing by Respiratory Consultants for TB patients, Ophthalmologists for the treatment of endophthalmitis or Microbiology consultants for any other indication.
05.01.12 Moxifloxacin 400mg/ 250mL  Restricted - prescribing by Microbiology or Respiratory Consultants for TB patients only.
02.05.02 Moxonidine 
09.06.07 Multivitamin preparations Abidec®

Oral Liquid (25mL Packs)

Not recommended for prescribing in primary care for routine supplementation: to be purchased OTC. Exclusions to this recommendation include use in pre-term infants and patients with a medically diagnosed deficiency (including a lifelong/chronic condition or surgery resulting in malabsorption e.g. cystic fibrosis)

09.06.07 Multivitamin preparations Dalivit®

Oral Drops (25mL Packs)

Not recommended for prescribing in primary care for routine supplementation:to be purchased OTC. Exclusions to this recommendation include use in pre-term infants and patients with a medically diagnosed deficiency (including a lifelong/chronic condition or surgery resulting in malabsorption e.g. cystic fibrosis).

12.02.03 Mupirocin 2% Bactroban Nasal®

Apply to both nostrils twice a day for 5 days.

13.10.01.01 Mupirocin 2%  Bactroban®
08.02.01 Mycophenolate Mofetil  

For continuing use in transplant patients.

 Hospital only for new transplant patients

Continue same brand / strength. Available as 250mg capsule, 500mg tablets various brands.

Also availabe as an oral suspension 1g in 5mL for patients with swallowing difficulties.

08.02.01 Mycophenolate Mofetil 500mg  For transplant patients who are unable to take orally.
08.02.01 Mycophenolate Mofetil 500mg 

Shared care for rheumatology patients

06.01.01.03 Mylife Penfine Classic needles ® 

4mm/32 gauge

6mm/32 gauge

For prescribing in primary care

02.06.04 Naftidrofuryl Oxalate 100mg  Restricted - only to be initiated under authorisation of a specialist and in accordance with NICE TA223 or CG147.
04.10.01 Nalmefene  18mg Tablets
Restricted - only to be initiated by a specialist in drug and alcohol problems or for continuing treatment in accordance with NICE TA325
01.06.06 Naloxegol  12.5mg & 25mg tablets

Naloxegol is recommended, within its marketing authorisation, as an option for treating opioid-induced constipation in adults whose constipation has not adequately responded to laxatives.

15.01.07 Naloxone  400microgram/1mL Injection
18 Naloxone 400micrograms/1mL 

Opioid poisoning

L&D and BHT - Kept on all wards / areas that use opioids.

04.10.01 Naltrexone 

50mg Tablets
Restricted - only to be prescribed by a specialist in drug and alcohol problems 


04.10.03 Naltrexone  50mg Tablets
Restricted - only to be initiated by a specialist in drug and alcohol problems or for continuing treatment according to NICE TA115.
See JPC shared Care Guidelines for opioid dependence and alcohol dependence.
10.01.01 Naproxen  250mg & 500mg Tablets
250mg & 500mg Enteric Coated Tablets
04.07.04.01 Naratriptan 2.5mg 
08.02.04 Natalizumab Tysabri®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

unlicensedunlicensed 300mg in 0.9% Sodium Chloride Infusion

20mg/1mL Injection

For specialist consultant prescribing in accordance with NICE TA127



05.01.04 Neomycin sulfate 500mg 

Approved as part of bowel prep prior to colorectal surgery at a dose of 1g TDS for one day.

Not to be prescribed for any other indications.

15.01.06 Neostigmine  2.5mg/1mL Injection
15.01.06 Neostigmine with Glycopyrronium 

Neostimine 2.5mg/Glycopyrronium 500microgram Injection

08.01.05 Neratinib Nerlynx®

FOR ALL PRESCRIBING - Blueteq or high cost drug form required - see link from Formulary Home Page.

Restricted for use in accordance with the following NICE TA(s):

05.03.01 Nevirapine  Restricted - must be prescribed by HIV consultants only

200mg Tablets
400mg Prolonged Release Tablets
50mg/5mL Suspension
02.06.02 Nicardipine 10mg/10mL 
02.06.03 Nicorandil 10mg & 20mg  Nicorandil may cause treatment resistant ulcers - in which case it should be stopped - see link to MHRA Drug Safety Update below
04.10.02 Nicotine Replacement Therapy 

7mg, 14mg & 21mg Patches (NiQuitin brand - releasing approx. 7mg, 14mg or 21mg over 24 hours). Leave on for 24 hours.

1.5mg, 4mg Mini Lozenges, mint (NiQuitin)

15mg Inhalator (Nicorette)

1mg per metered dose mouth spray - (Nicorette Quickmist)

2mg, 4mg gum (Nicorette)

N.B. Primary Care will only support the prescribing of monotherapy.

02.06.02 Nifedipine  Twice daily preparations:
10mg & 20mg MR Tablets (ADALAT RETARD)
10mg MR Capsules (CORACTEN SR)

Once Daily preparations:
30mg MR Capsules (CORACTEN XL)
20mg, 30mg, 60mg MR tablets (Adalat LA)
02.06.02 Nifedipine 20mg/ml 

unlicensed  For paediatric patients only.

02.06.02 Nifedipine 5mg, 10mg 

Short-acting nifedipine no longer recommended for angina or emergency or long-term management of hypertension; their use may be associated with large variations in blood pressure and reflex tachycardia.

Licensed for the treatment of Raynaud's disease.

08.01.05 Nilotinib Tasigna® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
150mg & 200mg Capsules

Approved in accordance with NICE TA425 and 426 for untreated chronic myeloid leukaemia.

02.06.02 Nimodipine Nimotop® 30mg Tablets
02.06.02 Nimodipine Nimotop® 0.2mg in 1mL Intravenous Infusion
08.01.05 Nintedanib  FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
100mg & 150mg Capsules

Approved in accordance with NICE TA347 for the treatment of metastatic non-small-cell lung cancer.
03.11 Nintedanib 100mg, 150mg Ofev® Restricted - to prescribing by a tertiary centre (e.g Brompton) for idiopathic pulmonary fibrosis - NICE TA 379.
08.01.05 Niraparib 100mg Zejula®

Funded by Cancer Drug Fund. Prescribing by specialist in line with NICE TA528.

04.01.01 Nitrazepam 2.5mg/5mL 

For Paediatric patients only

04.01.01 Nitrazepam 5mg 

No new initiations in Primary or Secondary care.

Exemption to exceptional use by Mental Health Trust.

05.01.13 Nitrofurantoin 25mg/5mL  All cases to be discussed with Consultant Microbiologist for alternatives.
Restricted for use in Paediatric outpatients or paediatric TTAs.
(The suspension now costs > £500 per 300mL bottle). Must not be prescribed on FP10 as may cost even more.
05.01.13 Nitrofurantoin 50mg, 100mg  First choice for community-acquired infection with no history of recurrent infection.

Nitrofurantoin is contraindicated in patients with an estimated glomerular filtration rate (eGFR) of less than 45 ml/min/1.73m2 this is in accordance with the MHRA.

15.01.02 Nitrous oxide 

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

15.01.02 Nitrous Oxide 50%/Oxygen 50% Entonox®
08.02.04 Nivolumab 10mg/1mL Opdivo®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - prescribing by Consultant Oncologists in accordance with NICE TA's below.

02.07.02 Noradrenaline / Norepinephrine  1 in 1000 (4mL) Injection
06.04.01.02 Norethisterone 

5mg Tablets

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

07.03.02.01 Norethisterone  350micrograms Tablets
Stock for Luton Sexual Health Clinic.
14.05.01 Normal immunoglobulin for Intravenous use 

High cost medicine. Strict funding criteria according to the Department of Health Guidelines. Contact pharmacy for advice (ward pharmacist or the commissioning pharmacist)

N.B. various brands available depending on availability (current national shortage) and hospital contracts. Brands include Privigen, Intratect, Octagam, Gammaplex and Kiovig.

04.03.01 Nortriptyline  10mg & 25mg Tablets

Restricted - To be initiated by pain specialists only, where amitriptyline has effectively controlled the neuropathic pain but the patient is intolerant to the side effects.

12.03.02 Nystatin 100,000units/mL 
01.09.01 Obeticholic acid Ocaliva ®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted to prescribing by specialists in accordance with NICE TA443 and following discussion with specialist centre at Addenbrookes Hospital.

08.02.03 Obinutuzumab Gazyvaro ®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in line with NICE TA's below.

08.02.02 Ocrelizumab Ocrevus®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage. Restricted - prescribing by Consultant Neurologists and clinical nurse specialists (MS) according to the following NICE TAs.

11.08.02 Ocriplasmin 0.5mg/0.2mL Jetrea® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA297 for the treatment of vitreomacular traction.
12.02.03 Octenisan 

MRSA protocol 1 (if mupirocin not unavailable):

Octenisan antimicrobial wash lotion 1 application OM for 5 doses

Octenisan nasal gel 1 application BD for 5 days

13.11 Octenisan® 

For MRSA decolonisation treatment as per Infection Control Policy.

To be used as a bodywash once daily for 5 days with mupirocin nasal ointment (or Octenisan nasal gel) twice daily for 5 days.

08.03.04.03 Octreotide Sandostatin Lar®

Funding can be claimed back for certain indications:

  • NHSE funded for all cancer indications

N.B. Please add a note on ePMA for the indication for this medicine to enable funding to be claimed.

08.03.04.03 Octreotide 50mcg, 100mcg, 500mcg Sandostatin®

Funding can be claimed back for certain indications:

  • NHSE funded for all cancer indications
  • CCG funded for post-pancreatic surgery; bleeding oesophageal varices; gastrointestinal fistulas (unlicensed indication - usual dose 100mcg TDS subcutaneously)

N.B. Please add a note on ePMA for the indication for this medicine to enable funding to be claimed.

18 Octreotide 50micrograms in 1mL 

Sulphonylurea toxicity

L&D - Kept in Pharmacy EDC fridge.

BHT - contact Pharmacy (Oncall Pharmacist via switchboard out of hours)

06.04.01.01 Oestrogen only HRT patch Evorel®

25mcg, 50mcg, 75mcg, 100mcg

 

06.04.01.01 Oestrogens conjugated (equine) for HRT Premarin®

300mcg, 625mcg, 1.25mg

06.04.01.01 Oestrogens for HRT (Estradiol) 

1mg & 2mg 

Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise

06.04.01.01 Oestrogens for HRT Gel  Sandrena®

500microgram, 1mg

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

06.04.01.01 Oestrogens for HRT patch Elleste-Solo® MX

40mcg, 80 mcg

For patients with skin allergy or poor absorption with Evorel or alternative adhesives

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

06.04.01.01 Oestrogens for HRT patch FemSeven®

50mcg, 75mcg, 100mcg

2nd-line choice after Evorel

When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

07.02.01 Oestrogens, Topical  0.01% Cream
Gynest brand has been discontinued, only available as generic
07.02.01 Oestrogens, Topical Ovestin® 0.1% Vaginal Cream
07.02.01 Oestrogens, Topical Vagifem® 10microgram Vaginal Tablets
08.02.03 Ofatumumab Arzerra® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in line with NICE TA202 & TA344
11.03.01 Ofloxacin 

0.3% Eye Drops

05.01.12 Ofloxacin 200mg, 400mg 
01.07.03 Oily phenol injection BP  5% injection
04.02.01 Olanzapine  2.5mg, 5mg, 7.5mg, 10mg & 20mg Tablets
5mg, 10mg, 15mg & 20mg Orodispersible Tablet

04.02.02 Olanzapine Embonate ZypAdhera®

Specialist initiation and continuation

08.01.05 Olaparib Lynparza®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

50mg hard capsules

100mg and 150mg film-coated tablets

Approved in accordance with the following NICE TA(s). NB NICE TA 598 indications  and one indication in TA 620 are funded via the Cancer Drugs Fund.

 

12.01.03 Olive Oil Ear Drops 
11.04.02 Olopatadine 1mg/1mL 
03.04.02 Omalizumab 150mg Xolair® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted to prescribing by NICE criteria or by approved individual funding request (IFR) ONLY.

1. Restricted - prescribing by Consultant Respiratory Physicians and Consultant Paediatricians in accordance with NICE TA 278 Omalizumab for treating severe persistent allergic asthma.

2. Restricted - prescribing by Consultant Dermatologists in accordance with NICE TA339 for previously treated chronic spontaneous urticaria.


05.03.03.02 Ombitasvir/ paritaprevir/ ritonavir Viekirax® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - to be initiated only by a Consultant Gastroenterologist/Hepatologist in accordance with NICE TA365 for the treatment of adults with chronic hepatitis C.

Ritonovir 12.5mg/Paritaprevir 50mg/Ombitasvir 75mg
01.03.05 Omeprazole  10mg, 20mg capsules
01.03.05 Omeprazole Losec®

10mg capsules
20mg capsules
10mg, 20mg MUPS (dispersible tablets)

Losec brand for enteral tube administration
or paediatric use only

 

 

01.03.05 Omeprazole IV  40mg vial for intravenous infusion
04.06 Ondansetron 

4mg & 8mg Tablets
4mg/5mL Syrup

4mg Orodispersible film - most cost-effective formulation

04.06 Ondansetron 4mg/2mL, 8mg/4mL 

If a parenteral antiemetic is indicated please prescribe ondansetron 4mg 4-6 hourly (up to TDS) first-line unless patients have one of the following exclusion criteria:

•congenital long QT syndrome
•hypersensitivity to ondansetron or other 5HT3- receptor antagonists
•sub-acute intestinal obstruction or ileus (this is a caution not a contraindication in the SPC)

N.B. parenteral cyclizine is now very expensive (about 40 x that of ondansetron).

04.09.01 Opicapone 50mg  Must be initiated by a Neurologist who specialises in Parkinson’s Disease and may be continued by the GP.

Only for patients who cannot tolerate entacapone as per JPC bulletin.
09.02.01.02 Oral Rehydration Salts Dioralyte®
04.05.01 Orlistat  120mg Capsules
04.09.02 Orphenadrine 

50mg Tablets
50mg/5mL Oral Solution

05.03.04 Oseltamivir Tamiflu® First Choice where indicated
30mg, 45mg & 75mg Capsules
30mg/5mL oral suspension - only for children under 1 year.

For enteral tube administration the capsules can be opened and mixed with a little water. The dispersion will flush down an 8 Fr tube without blockage. Flush well.

Prescribing for children over 12 months and adults who are not able to swallow capsules should be at the appropriate dose. The contents of the capsule should be added to a suitable sugary diluent. Where possible oseltamivir powder for suspension should be restricted for children under 1 year of age. This will ensure that there are adequate stocks in the supply chain, for this vulnerable group of patients (from recent CMO alert 19/12/17).

It is important that adults and children start taking oseltamivir within 48 hours of onset of symptoms. For zanamivir, treatment should begin within 48 hours of onset of symptoms for adults and within 36 hours of onset of symptoms for children who are 5 years of age or over.

Restricted - to be initiated on Consultant authorisation in accordance with NICE TA 158/168 or on Microbiologist advice.
08.01.05 Oxaliplatin  unlicensedunlicensed 75mg - 260mg in 5% Glucose Infusion (250mL)
unlicensedunlicensed 150mg - 270mg in 5% Glucose Infusion (500mL)

Approved in accordance with NICE TA100

Restricted - must only be prescribed by staff with specialist training in Oncology or Haematology
04.01.02 Oxazepam 

For initiation by Mental Health specialist from ELFT only

04.08.01 Oxcarbazepine  150mg, 300mg & 600mg Tablets
300mg/5mL Suspension

Prescribing generically or by brand is discretionary.

Restricted - to initiation by Neurology specialists, with continuation by GPs and to be used in accordance with NICE CG137 - see link above.(Replaces NICE TA76).
11.07 Oxybuprocaine Hydrochloride Minims® 0.4% Single Dose - Preservative free
07.04.02 Oxybutynin Hydrochloride Kentera®

Do not offer oxybutynin (immediate release) to older women who may be at higher risk of a sudden deterioration in their physical or mental health.

For use in patients with swallowing difficulties only.

07.04.02 Oxybutynin Hydrochloride 5mg/5mL  5mg in 5ml - Unlicensed - Low Risk
Restricted - for use only in patients unable to swallow tablets or for whom crushing/dispersing immediate release tablets is not suitable. N.B. £240 per 150mL bottle.
NOTE - immediate release (ordinary) tablets can be dispersed/crushed in 10ml water and administered orally or via NG/PEG tubes.
In primary care this is a pharmaceutical special.
07.04.02 Oxybutynin Hydrochloride 2.5mg, 3mg & 5mg 

NOTE - immediate release (ordinary) tablets can be dispersed/crushed in 10ml water and administered orally or via NG/PEG tubes.

07.04.02 Oxybutynin Hydrochloride Modified Release  Restricted to be used where ordinary tablets have caused side effects or where concordance is an issue.
04.07.02 Oxycodone  10mg/1mL Injection
 
Restricted - Only to be prescribed 2nd line, if morphine sulphate is not suitable appropriate or tolerated.

50mg/1mL Injection - Ordered on a named patient basis only. Write patient's name and hospital number in CD order book.
04.07.02 Oxycodone 10mg, 20mg, 40mg, 80mg   Green Traffic Light  Restricted - 2nd-line use. Only to be prescribed if morphine sulphate is not suitable. Prescribe as a regular dose.

Red Traffic Light  ENHANCED RECOVERY
Restricted - to initiation by Anaesthetics team and continuation by the Pain team and ward surgical and orthopaedic doctors, for pain management in enhanced recovery for hip and knee arthroplasty surgical patients, in accordance with Enhanced Recovery protocol (see link below). Maximum 5 days in total.

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfil the legal requirements of controlled drug prescriptions. e.g. Please supply twenty eight (28) tablets (signed).

04.07.02 Oxycodone 5mg, 10mg  Restricted - not for in-patient use. For 2nd-line use only, where morphine sulphate is not appropriate or tolerated.
Usually prescribed for ’prn’ dose e.g for enhanced recovery patients on discharge following knee or hip arthroplasty.

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and countersigned in order to fulfill the legal requirements of controlled drug prescriptions.
04.07.02 Oxycodone 5mg/ 5mL  Restricted - for inpatient use only. Usually for ’prn’ use with regular oxycodone MR tablets.
For 2nd-line use only, where morphine sulphate is not appropriate or tolerated.

N.B. Must change to immediate release capsules on discharge if still required.
05.01.03 Oxytetracycline 250mg 
07.01.01 Oxytocin  5units/1mL Injection
10units/1mL Injection
08.01.05 Paclitaxel  FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in accordance with NICE TA389 & TA108 for the treatment of node-positive breast cancer and recurrent ovarian cancer.

08.01.05 Paclitaxel - Albumin Bound Formulation Abraxane® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved for the treatment of breast cancer in patients who have documented Taxane hypersensitivity, in accordance with routine NHSE commissioning.
Approved in accordance with TA476 for untreated metastatic pancreatic cancer.
08.01.05 Palbociclib 75mg, 100mg, 125mg Ibrance®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage. 

Approved in accordance with the following NICE TAs:

NB : TA 619 is funded via the Cancer Drugs Fund

04.02.01 Paliperidone 

For initiation and continuation by Mental Health specialists

04.02.02 Paliperidone Xeplion®

Specialist initiation and continuation

05.03.05 Palivizumab 50mg, 100mg Synagis® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - prescibing by Consultant Paediatricians only in accordance with JCVI criteria. Approval required prior to initiation.
04.06 Palonosetron with netupitant Akynzeo® For chemotherapy patients
01.09.04 Pancreatin Pancrex® V Oral powder
01.09.04 Pancreatin Creon® Micro For Paediatric use only
01.09.04 Pancreatin Creon®

10,000 units/capsule

25,000 units /capsule

PLease note the 40,000 unit strength has now been discontinued (May 2019)

15.01.05 Pancuronium Bromide  4mg/2mL Injection
08.01.05 Panitumumab Vectibix®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

20 mg/mL concentrate for solution for infusion

Approved in accordance with NICE TA 439 

 

08.01.05 Panobinostat Farydak® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
20mg Capsules

Approved in accordance with NICE TA380.


01.03.05 Pantoprazole 20mg, 40mg 

Hospital prescribing: this is not the most cost-effective PPI so should not be initiated in hospital but will be continued for patients admitted on this.

04.07.01 Paracetamol 

500mg Tablets
120mg & 250mg in 5mL Suspension (Sugar free solutions available)
120mg, 240mg & 1000mg Suppositories
500mg Soluble Tablets

For short term acute use in Primary Care patients should be advised to purchase over the counter

04.07.01 Paracetamol 1g / 100mL 

For adults

Restricted - only to be used when the oral route is not available. The rectal route is an alternative to the I.V. route where appropriate.

Please ensure weight is documented on ePMA and dose adjusted accordingly. N.B. for patients < 50kg maximum dose is 15mg/kg QDS.

 

Patient Group

 

Dose

 

Minimum dosing interval

 

Maximum daily dose

 

More than 50kg

 

1g max QDS

 

Every 4 hours

 

4g

 

 

Less than 50kg

 

15mg/kg max QDS

 

Every 4 hours

 

 

60mg/kg (or max 3g daily)

CrCl less than 30mL/min

According weight

(more than or less than 50kg)

 

Every 6 hours

According weight

(more than or less than 50kg)

04.07.01 Paracetamol 500mg and codeine 30mg Co-codamol® 30/500 Tablets and effervescent tablets
04.07.01 Paracetamol 500mg and codeine 8mg Co-codamol® 8/500 Tablets and effervescent tablets

04.07.01 Paracetamol 500mg/ 50mL 

Restricted to paediatrics.

04.07.01 Paracetamol and dihydrocodeine Co-dydramol® 10mg/500mg Tablets
04.08.02 Paraldehyde - Enema In Olive Oil   Paediatrics only
04.03.03 Paroxetine 

For specialist initiation or on the advice of a Mental Health Specialist

09.02.01.01 Patiromer Veltassa® 8.4g;16.8 g; 25.2g powder for oral suspension

Amber For ongoing treatment of hyperkalaemia in accordance with NICE TA.

N.B. Specialists must provide GP's with guidance on monitoring required.

Red  For acute treatment of hyperkalaemia

For use in accordance with the following NICE TA:-

08.01.05 Pazopanib Votrient® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Approved in line with NICE TA215.
08.02.04 Peginterferon Alfa-2a 135mcg, 180mcg Pegasys®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

No longer prescribed for hepatitis C in adults. 

For continuation of treatment in patients with hepatitis B in combination with adefovir dipivoxil.

08.02.04 Peginterferon beta-1a Plegridy®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

Restricted - prescribing by Consultant Neurologists and clinical nurse specialists (MS) as a first line treatment option for adults with relapsing-remitting multiple sclerosis in accordance with NHS England circular SSC1534 and/or the following NICE TA:-

06.05.01 Pegvisomant Somavert®

PbR excluded - funding approval required.

Funded by NHS England.

08.01.05 Pembrolizumab Keytruda®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage. OR may be funded through the Cancer Drug Fund.
50mg Powder for concentrate for solution

Approved in accordance with the NICE TA's below.

08.01.03 Pemetrexed Alimta® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted to prescribing by Oncologists in accordance with NICE TA's below.
18 Penicillamine 125mg Distamine

For copper poisoning and Wilson disease. (Not lead poisoning).

L&D - Kept in Pharmacy EDC.

BHT - Contact Pharmacy (Oncall via switchboward out of hours)

05.04.08 Pentamidine Isetionate Pantacarinat® 300mg Injection
22mg in 11ml water for injection
24mg in 12ml water for injection
26mg in 13ml in NaCl 0.9%
07.04.03 Pentosan Polysulphate Elmiron®

Restricted use in accordance with the following NICE TA (s):

08.01.05 Pentostatin Nipent® 10mg Injection
unlicensedunlicensed 8mg in 0.9% Sodium Chloride Infusion (50mL)

Restricted - must only be prescribed by staff with specialist training in Oncology or Haematology
02.06.04 Pentoxifylline 400mg Trental®

No longer recommended by NICE for the treatment of intermittent claudication in people with peripheral arterial disease.

Restricted use:
Approved by DTC for the treatment of osteoradionecrosis of the jaw (off-label use). Dose is 400mg BD. Patients are to purchase vitamin E 1000 units daily to take with this treatment.

01.02 Peppermint Oil 

0.2ml capsules. Licensed for irritable bowel syndrome.

N.B. modified release capsules are non-formulary

01.02 Peppermint water 

Bedford hospital only until review completed.

L&D: Removed from Formulary (DTC decision). No evidence of cost-effectiveness, only has a herbal medicine license and is expensive (about £10 per bottle).

01.01.02 Peptac 

Primary care and Bedford hospital only.

L&D: prescribe Gaviscon Advance.

6.2mmol sodium per 10mL

04.02.01 Pericyazine 

Restricted use in Mental Health Trusts

02.05.05.01 Perindopril erbumine 

2mg, 4mg & 8mg Tablets

N.B. also known as peridopril tert-butylamine

13.10.04 Permethrin 1% Lyclear® Creme Rinse Cream Rinse
1% Lotion
13.10.04 Permethrin 5% Lyclear® Dermal Cream

For inpatient use only, not to be prescribed on TTO.

Self-care in primary care

08.01.05 Pertuzumab Perjeta®

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
To be prescribed by specialists in line with NICE TA's below or CDF advanced breast cancer criteria.

04.07.02 Pethidine  50mg/1mL Injection
100mg/2mL Injection
02.08.02 Phenindione 10mg 

No new initiations.

Review current patients and switch to more cost-effective and available anticoagulant if possible.

04.08.01 Phenobarbital  50mg/5mL Oral Solution for paediatrics (alcohol free)

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfill the legal requirements of a controlled drug prescriptions. e.g. Please supply Fifty milliliters (50 mL) (signed).
04.08.02 Phenobarbital  30mg/1mL, 60mg/1mL & 200mg/1mL Injection
04.08.01 Phenobarbital 15mg, 30mg 

Must prescribe by brand name.

When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfill the legal requirements of a controlled drug prescriptions. e.g. Please supply 30 (thirty) (signed).

04.08.01 Phenobarbital 30mg, 60mg 
02.05.04 Phenoxybenzamine Hydrochloride  10mg Capsules

For hypertensives episodes due to phaeochromocytoma.

Stocked in Pharmacy EDC
05.01.01.01 Phenoxymethylpenicillin  250mg Tablets
125mg & 250mg in 5mL Oral Solution
18 Phentolamine 10mg/1mL  

unlicensedunlicensed
Digital ischaemia related to injection of adrenaline (epinephrine)
Resistant hypertension caused by sympathomimetic drugs of abuse, monoamine-oxidase inhibitors (MAOIs), clonidine

L&D - Kept in ED fridge, Pharmacy EDC fridge and Theatres 1-6 fridge.

BHT - Contact Pharmacy (Oncall Pharmacist via switchboard out of hours)

02.05.04 Phentolamine 10mg/mL 

unlicensedunlicensed

For hypertensives episodes due to phaeochromocytoma.

L&D: Stocked in ED fridge, Pharmacy EDC fridge and Theatres 1-6 fridge.

02.07.02 Phenylephrine  1% Injection (1mL)
100micrograms in 1mL Injection Ampoule
11.05 Phenylephrine & tropicamide Mydriasert® To be used prior to cataract surgery.
11.05 Phenylephrine / tropicamide/ lidocaine Mydrane® For cataract surgery where additional mydriasis is needed.
11.05 Phenylephrine Hydrochloride  2.5% & 10% Single Dose Eye Drops - Preservative free
04.08.01 Phenytoin 

25mg, 50mg & 100mg Capsules
30mg/5mL Suspension

Preparations containing phenytoin sodium are not bioequivalent to those containing phenytoin base (such as Epanutin Infatabs® and Epanutin® suspension); 100 mg of phenytoin sodium is approximately equivalent in therapeutic effect to 92 mg phenytoin base.

WARNING: Prescribe by brand to ensure patient is maintained on a specific manufacturer's product.

04.08.02 Phenytoin  250mg/5mL Injection
03.09.01 Pholcodine Linctus BP  5mg in 5mL Linctus
09.05.02.01 Phosphate Polyfusor® 

50mmol/500mL Infusion

09.05.02.01 Phosphate supplements Phosphate-Sandoz® 500mg Effervescent Tablets - contains 16.1mmol phosphate, 20.4mmol sodium and 3.1mmol potassium
01.06.04 Phosphates (Rectal)  Enema (Cleen - formerly Fleet)
09.06.06 Phytomenadione Konakion® MM Paediatric 2mg/0.2mL Injection
BNF states: may be administered by mouth, or by intramuscular injection or by intravenous injection
09.06.06 Phytomenadione Konakion® MM

10mg/1mL Injection
BNF states: may be administered by slow intravenous injection or by intravenous infusion in glucose 5%. NOT for intramuscular injection
This has also been given orally but is off-label. The formulation is the same as the paediatric konakion MM and has been checked with the manufacturer. For oral doses less than 10mg prescribe paediatric Konakion MM.

01.06.05 Picolax® 

Oral powder - Bowel cleansing only

11.06 Pilocarpine  1%,2%,4% eye drops
2% single use preservative-free eye drops (Minims)
13.05.03 Pimecrolimus 1% Elidel® Approved in accordance with NICE TA82 for the treatment of mild atopic eczema. For more information click the link below.
04.02.01 Pimozide 

For restricted use in Mental Health Trust

06.01.02.03 Pioglitazone  15mg, 30mg & 45mg Tablets

Restricted - to be used in accordance with NICE Clinical Guideline NG28 Management of Type 2 Diabetes
05.01.01.04 Piperacillin and Tazobactam 

2.25g & 4.5g Injection

Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.

May be given by slow intravenous bolus over 5 minutes (unlicensed) as documented in the Medusa IVGUIDE.

04.02.02 Pipotiazine Palmitate 50mg/1mL 

Specialist initiation and continuation

03.11 Pirfenidone 267mg Esbriet®

Restricted - prescribing in accordance with NICE TA504 with initiation by consultant Respiratory physicians in named Specialist Services only (Oxford University Hospitals NHS Trust, Interstitial Lung Disease Service (ILD Service), University Hospital Southampton NHS Trust, Royal Brompton & Harefield NHS Foundation Trust, Imperial College Healthcare NHS Trust and Guys and St Thomas' NHS Foundation Trust) and prescribing may be continued in LDH by Consultant Respiratory physicians. It must be verified, via blueteq, that funding approval has been obtained.
LDH will not stock pirfenidone. If a patient is admitted to LDH with IPF exacerbations supplies to be obtained from either the patient or the Specialist Service.

05.01.01.05 Pivmecillinam 200mg 

PRIMARY CARE: joint first-line option for treatment of UTI. refer to the Bedfordshire & Luton Community Antimicrobial Guidelines (link on home page)

SECONDARY CARE: Restricted Item Restricted use:

  • Not to be prescribed empirically for first-line use (to preserve for Primary Care use)
  • Sensitivities must be known
  • Must have Microbiology approval before prescribing
08.01.02 Pixantrone  FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
unlicensedunlicensed Pixantrone 90mg in 0.9% Sodium Chloride Infusion (250mL)

Approved in accordance with NICE TA306.

04.07.04.02 Pizotifen  500microgram Tablets
1.5mg Tablets
09.02.02.02 Plasma-lyte 148  Restricted for critically ill patients with metabolic acidosis.
14.04 Pneumococcal polysaccharide conjugate vaccine (adsorbed) Prevenar 13®
  • For active immunisation of all ages
  • For individuals over the age of 18 years and between the age of 2-17 Years a single dose is required.
  • For infants below 2 years two doses are required.
  • 14.04 Pneumococcal polysaccharide conjugate vaccine (adsorbed) Pneumovax II® PPV23 (23 valent)

    Recommended 2 weeks before or 2 weeks after splenectomy plus further boosters.

    13.07 Podophyllotoxin 0.15% Condyline®or Warticon®

    Restricted - only to be prescribed by a clinician who is experienced in its use.

    11.03.01 Polihexanide 

    For acanthamoeba keratitis

    09.02.01.01 Polystyrene Sulphonate Resins Calcium Resonium®
    08.02.04 Pomalidomide Imnovid®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    For specialist prescribing in line with NICE TA427.

    08.01.05 Ponatinib 15mg, 30mg, 45mg Iclusig® Approved in accordance with NICE TA451 for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia.
    03.05.02 Poractant Alfa 120mg/1.5mL, 240mg/3mL Curosurf®

    Restricted - Consultant Paediatrician prescribing in NICU only.

    05.02 Posaconazole (IV) Noxafil® High Cost drug. Microbiology approval only.
    Must confirm funding approval with the Commissioning Pharmacist on ext:8048 before prescribing and send prescriptions to the hospital pharmacy.

    Funded by NHS England.
    05.02 Posaconazole (oral) Noxafil® High Cost drug. Microbiology approval only.
    Must confirm funding approval with the Commissioning Pharmacist on ext:8048 before prescribing and send prescriptions to the hospital pharmacy.

    Funded by NHS England.
    11.99.99.99 Potassium Ascorbate (Ascorbic acid) 10%  Prescribing by Ophthalmologists for acid or alkali burns to the cornea.

    N.B. stocked in the Emergency Drug Cupboard.
    09.02.01.01 Potassium Chloride Sando-K® Effervescent Tablets each containing 12mmol potassium and 8 mmol chloride
    09.02.01.01 Potassium Chloride Kay-Cee-L® 1mmol/mL each of potassium and chloride
    09.02.02.01 Potassium Chloride and Glucose Intravenous Infusion  

    Contains 0.15% (20mmol) potassium in glucose 5%.

    500mL or 1L bags.

    09.02.02.01 Potassium Chloride and Sodium Chloride Intravenous Infusion 

    10mmol potassium in sodium chloride 0.9% x 500mL

    20mmol potassium in sodium chloride 0.9% x 500ml and 1L 

    40mmol potassium in sodium chloride 0.9% x 1L

    09.02.02.01 Potassium Chloride Concentrate (Sterile)  CAUTION:- CONCENTRATED POTASSIUM SOLUTION

    Restricted - to wards eg ITU, HDU and other named wards, in accordance with Trust Potassium Policy. Treated as controlled drug (CD).
    09.02.02.01 Potassium Chloride, Sodium Chloride and Glucose Intravenous Infusion 

    10mmol or 20mmol potassium in glucose 5% and sodium chloride 0.45% x 500mL

    07.04.03 Potassium Citrate  200mL Pack
    NOTE: Usual dose is 10mL, three times daily for two days.
    06.02.02 Potassium Iodide  60mg capsules

    Available in the Emergency Drug Cupboard. Bleep 555 out of hours if needed.
    13.11.06 Potassium Permanganate 400mg Permitab®
    11.03.01 Povidone iodine 5% 
    13.11.04 Povidone-iodine 2.5% 
    18 Pralidoxime chloride 1g in 2mL 

    Organophosphorus insecticide toxicity.

    L&D - Kept in ED antidote cupboard.

    BHT - Contact Pharmacy (Oncall Pharmacist via switchboard out of hours)

    04.09.01 Pramipexole  88mmicrograms, 180micrograms, 350micrograms, 700micrograms

    N.B. prolonged release formulation non-formulary.
    02.09 Prasugrel Efient® Restricted - Only to be initiated under Cardiology authorization and in accordance with NICE TA182/TA317

    5mg & 10mg Film Coated Tablets
    02.12 Pravastatin  
    05.05.05 Praziquantel 150mg, 600mg  unlicensedunlicensed - Available from specialist importing companies.
    Restricted - consultant authorisation required.
    07.04.01 Prazosin  500microgram & 1mg Tablets
    01.05.02 Prednisolone 

    5mg suppositories
    20mg retention enema

    06.03.02 Prednisolone Soluble Tablets 5mg Restricted to paediatric patients under 4 years old only, due to prohibitive cost increase.
    NOTE: ordinary 5mg tablets can be crushed, dispersed in water and administered orally or via PEG/NG tubes.
    06.03.02 Prednisolone  1mg, 5mg, 20mg Tablets

    08.02.02 Prednisolone  1mg, 5mg &
    Restricted Item 20mg tablets Restricted to chemotherapy patients or those on higher doses



    11.04.01 Prednisolone  

    0.5% & 1% Eye Drops

    12.01.01 Prednisolone 0.5% Predsol®

     Ear/eye drops

    11.04.01 Prednisolone preservative free eye drops 

    For patients who are allergic to preservatives
    0.5% eye drops

    04.02.03 Pregabalin 

    Requires specialist initiation for Generalised Anxiety Disorder

    04.07.03 Pregabalin 

    25mg, 50mg, 75, 100mg, 300mg capsules.

    Third-line choice for neuropathic pain in accordance with JPC guidance. See link below.

    04.08.01 Pregabalin 

    May be prescribed generically. Several strengths available - refer to BNF.

    When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and countersigned in order to fulfill the legal requirements of controlled drug prescriptions.

    15.02 Prilocaine Hydrochloride 1% Citanest®
    15.02 Prilocaine Hydrochloride 20mg/mL Prilotekal®

    For use in adults for spinal anaesthesia for short term surgical procedures in day case surgery

    5mL ampoule

    05.04.01 Primaquine 7.5mg   unlicensedunlicensed - phone Pharmacy to order.
    Restricted - For the treatment of malaria only under specialist authorisation.

    04.08.01 Primidone  50mg & 250mg Tablets
    A2.05.01 Probiotics  Vivomixx ®

    For patients at HIGH risk of developing C.difficile associated diarrhoea (CDAD) receiving broad spectrum antibiotics, according to attached Luton & Dunstable hospital protocol.

    Start at the same time as broad spectrum antibiotics and continue for 7 days after stopping. Prescribe the whole course on discharge.

    A2.05.01 Probiotics Labinic®

    Neonatal unit only:  for the prevention of necrotising enterocolitis (NEC) in high risk pre-term infants (as per approved guideline).

    05.01.01.01 Procaine Benzylpenicillin 1.2megaunits 

    unlicensed unlicensed

    For the treatment of syphilis only. Follow most up-to-date BASHH guidelines, see link below:

    08.01.05 Procarbazine  50mg Capsules

    Restricted - must only be prescribed by staff with specialist training in Oncology or Haematology
    04.06 Prochlorperazine  5mg Tablets
    5mg/5mL Syrup
    04.09.02 Procyclidine 

    5mg Tablets
    5mg/5mL Syrup

    18 Procyclidine 10mg in 2mL 

    Acute dystonia, dystonic reactions

    L&D - Kept in ED antidote cupboard.

    BHT - Kept in Accident & Emergency

    06.04.01.02 Progesterone 

    200mg & 400mg Pessaries

    05.04.01 Proguanil Hydrochloride 100mg   Not for malaria prophylaxis - private GP prescription needed.

    05.04.01 Proguanil Hydrochloride with Atovaquone 100mg/ 250mg Malarone® Restricted - For the treatment of malaria only under specialist authorisation.

    Not for malaria prophylaxis - private GP prescription needed.
    03.04.01 Promethazine Hydrochloride   10mg, 25mg tablets
    5mg/5mL Elixir
    04.01.01 Promethazine Hydrochloride  See Section 3.4.1

    Less suitable for prescribing as a sedative (short term use).

    04.06 Promethazine hydrochloride 

    For preparations see Section 03.04.01

    03.04.01 Promethazine Hydrochloride 25mg/ 1mL 
    A5.04.01 Promogran  123cm x 123cm Dressing
    28cm x 28cm Dressing

    For use when recommended by TVN. Not routinely stocked - order for individual patient.
    A5.04.01 Promogran Prisma  123cm x 123cm Dressing
    28cm x 28cm Dressing

    For use when recommended by TVN. Not routinely stocked - order for individual patient.
    02.03.02 Propafenone 150mg, 300mg 
    11.03.01 Propamidine Isetionate Brolene®

    For acanthamoeba keratitis

    15.01.01 Propofol  1% & 2% Injection
    1% Pre-filled Syringe
    200mg/20mL Injection
    02.04 Propranolol  10mg, 40mg & 80mg tablets
    80mg MR capsules
    10mg in 5mL sugar-Free Solution
    50mg in 5mL sugar-Free Solution

    04.07.04.02 Propranolol  10mg, 40mg & 80mg Tablets
    80mg MR Tablets
    10mg in 5mL Sugar-Free Solution
    50mg in 5mL Sugar-Free Solution

    Migraine prophylaxis: 80–240 mg daily in divided doses

    06.02.02 Propylthiouracil  50mg Tablets
    18 Protamine Sulphate 50mg in 5mL 

    For heparin overdose.

    L&D - Kept in Theatres, ITU, CCU.

    BHT - Kept on AAU, Coronary Care Ward, ICU and various other wards

    02.08.03 Protamine Sulphate 50mg/5mL Prosulf®
    06.05.01 Protirelin  TRH

    200micrograms/ 1mL injection

    11.07 Proxymetacaine Hydrochloride 0.5% Minims® Single use, preservative-free.
    01.06.07 Prucalopride Resolor ® Females only, with authorisation from a Gastroenterologist in line with NICE TA211.

    Patient must have tried at least two different types of laxatives at the highest possible recommended doses, for at least 6 months, and are considering invasive treatment for constipation.
    Treatment must be reviewed after 4 weeks.
    N.B. Only to prescribe in women as NICE have not approved for use in men yet.

    1mg & 2mg film coated tablets
    05.01.09 Pyrazinamide 500mg 
    05.01.09 Pyrazinamide 500mg/5mL  Restricted - Microbiology or Consultant approval required.
    unlicensedunlicensed
    10.02.01 Pyridostigmine Bromide Mestinon®

    60mg Tablets
    unlicensedunlicensed 10mg/1mL Suspension

    18 Pyridoxine 100mg in 2mL 

    Isoniazid toxicity

    L&D - Kept in ED antidote cupboard.

    BHT - Kept on Meadowbank ward

    09.06.02 Pyridoxine Hydrochloride  unlicensedunlicensed 100mg/2mL Injection

    Restricted - must only be prescribed by paediatric team
    09.06.02 Pyridoxine Hydrochloride 50mg   Can be crushed and mixed with water to administer down an enteral feeding tube.
    09.06.02 Pyridoxine Hydrochloride 50mg in 5mL  For paediatrics only
    04.02.01 Quetiapine 

    25mg, 50mg, 100mg, 150mg, 200mg and 300mg tablets

    Preferred formulation in primary care

    04.02.01 Quetiapine XL 

    Primary care: Most cost effective brand to be advised via ScriptSwitch/ Optimise. Reserved for use if patient is unable to tolerate immediate release formulation

    Secondary care: hospital contract brand will be provided

    05.04.01 Quinine Dihydrochloride 300mg/1mL  unlicensedunlicensed
    Restricted - for the treatment of malaria under specialist advice.

    05.04.01 Quinine Sulphate 200mg, 300mg  Restricted if for the treatment of malaria under specialist authorisation only.

    If used for treating cramp see Section 10.02.02
    14.04 Rabies Immunoglobulin 

    Public Health England are required to perform a risk assessment and authorise use of this product.

    Dr (usually A&E) would need to contact PHE at Collindale 02083277472

     

    14.04 Rabies vaccine 

    Post-exposure: Must risk assess according to PHE guidelines (attached)with discussion with a Microbiologist.

    Primary Care (Pre-Exposure): This vaccine should not be prescribed on the NHS exclusively for the purposes of travel

    N.B. Bedford Hospital is a holding centre

    06.04.01.01 Raloxifene Hydrochloride Evista®

    Follow NICE guidance.

    Raloxifene is not recommended as a treatment for preventing fractures in postmenopausal women with osteoporosis who have not had a fracture.

    05.03.01 Raltegravir Isentress ® 25mg Tablets
    400mg Film Coated Tablets
    Restricted - must be initiated by HIV consultants only
    08.01.03 Raltitrexed Tomudex® 4mg - 6mg in 0.9% Sodium Chloride Infusion (100mL)

    Restricted - prescribing by consultant oncologists only in accordance with NICE clinical guideline 131.
    02.05.05.01 Ramipril  1.25mg, 2.5mg, 5mg & 10mg Capsules
    11.08.02 Ranibizumab 0.5mg/0.5mL Lucentis® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Restricted - prescribing by consultant Ophthalmologists:

    1. For the treatment of age related macular degeneration in accordance with NICE TA155.
    2. For treating diabetic macular oedema in accordance with NICE TA274.

    3. For Central Retinal Vein Occlusion in accordance with NICE TA283

    4. For treatment of visual impairment due to choroidal neovascularisation (CNV) secondary to pathologic myopia in accordance with NICE TA 298.


    01.03.01 Ranitidine 

    150mg & 300mg tablets
    150mg effervescent tablets
    75mg in 5ml S/F solution

    01.03.01 Ranitidine 50mg in 2mL 
    02.06.03 Ranolazine Ranexa®
    04.09.01 Rasagiline 1mg 
    10.01.04 Rasburicase 1.5mg, 7.5mg Fastertec® Restricted - to consultant oncologists and haematologists for treatment of cytotoxic induced hyperuricaemia
    04.03.04 Reboxetine Edronex®

    For initiation by Mental Health specialist from ELFT only

    08.01.05 Regorafenib 40mg Stivarga®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in accordance with the NICE TA's below.

    05.03 Remdesivir 100mg 

    unlicensed unlicensed

    Early Access Medicine Scheme (EAMS)

    Patients must fulfil set criteria to be eligible for this medicine - contact Pharmacy for information if needed.

    N.B.  We will not receive any further supplies unless the required paperwork is completed. Paperwork needed:

    Unlicensed Medicine Request form at initiation; ISARIC clinical outcome form; adverse event form.

    Contact your ward pharmacist or pharmacy for supply.

    L&D - Out of hours some stock is available in the emergency cupboard fridge. Contact 555 to access or on-call pharmacist for information.

    Bedford - Out of hours contact the oncall Pharmacist

    15.01.04.03 Remifentanil Ultiva® 1mg, 2mg & 5mg Injection
    06.01.02.03 Repaglinide  0.5mg, 1mg 2mg tablets

    03.04.02 Reslizumab Cinquil®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in accordance with NICE TA479 for treating severe refractory eosinophilic asthma.

    05.03.05 Ribavirin 200mg  FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in accordance with NICE TA75, TA106 & TA200 for the treatment of chronic hepatitis C.
    05.03.05 Ribavirin 200mg, 400mg Copegus® Restricted - prescribe only when capsules are unavailable.

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in accordance with NICE TA75, TA106 & TA200 for the treatment of chronic hepatitis C as above.


    08.01.05 Ribociclib 200mg 

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage. 

    Approved in accordance with the following NICE TA(s):-

    (NB For TA593, funding is via the Cancer Drugs Fund)

    05.01.09 Rifampicin   150mg & 300mg Capsules
    100mg/5mL syrup

    Restricted - Microbiology or consultant approval required.

    Oral bioavailability is near 100%. Food delays the rate and extent of absorption so an oral dose should be taken at least 30 minutes before or 2 hours after food. Oral rifampicin is significantly less expensive than IV; so early switch to oral therapy is encouraged.

    Must always be prescribed with another antibiotic.
    05.01.09 Rifampicin 600mg  Restricted - Microbiology or consultant approval required.
    05.01.09 Rifampicin and Isoniazid Rifinah® Rifampicin 150mg/Isoniazid 100mg Tablets
    Rifampicin 300mg/Isoniazid 150mg Tablets
    Restricted - Microbiology or consultant approval required.
    05.01.09 Rifampicin and Isoniazid and Pyrazinamide Rifater® Restricted - Microbiology or Consultant approval required.
    Rifampicin 120mg/ Isoniazid 50mg/ Pyrazinamide 300mg tablet

    Initial unsupervised treatment of tuberculosis (in combination with ethambutol)

    By mouth
    Adult (body-weight up to 40 kg)
    3 tablets daily for 2 months (initial phase), use Rifater® Tablets, preferably taken before breakfast.
    Adult (body-weight 40–49 kg)
    4 tablets daily for 2 months (initial phase), use Rifater® Tablets, preferably taken before breakfast.
    Adult (body-weight 50–64 kg)
    5 tablets daily for 2 months (initial phase), use Rifater® Tablets, preferably taken before breakfast.
    Adult (body-weight 65 kg and above)
    6 tablets daily for 2 months (initial phase), use Rifater® Tablets, preferably taken before breakfast.

    05.01.07 Rifaximin 550mg Targaxan® Restricted - prescribing by Consultant Hepatologists in accordance with NICE TA 337.
    05.03.01 Rilpivirine hydrochloride Edurant® 25mg Tablets

    Restricted - must be prescribed by HIV consultants only
    04.09.03 Riluzole 50mg 

    Riluzole tablets should be prescribed generically

    To be initiated by Consultant neurologists only in accordance with NICE TA20.

    04.09.03 Riluzole 5mg/mL Teglutik® Restricted: Only for use in patients with swallowing difficulties- SALT assessment required) To be initiated by Consultant neurologists only in accordance with NICE TA20.
    13.05.03 Risankizumab  Skyrizi®

    FOR ALL PRESCRIBING - Blueteq or High Cost Drug Form required - see link from Formulary Homepage.

    Restricted to Specialist Prescribing in accordance with the following NICE TA(s):-

     

    06.06.02 Risedronate  2nd Choice for osteoporosis
    2nd line treatment when intolerant to alendronate.
    5mg & 35mg Tablets
    04.02.01 Risperidone  0.5mg, 1mg, 2mg, 3mg, 4mg & 6mg Tablets
    0.5mg, 1mg, 2mg & 3mg Orodispersible Tablet
    1mg/1mL Oral Liquid
    04.02.02 Risperidone Risperdal Consta®

    Specialist initiation and continuation

    05.03.01 Ritonavir 

    Restricted - must be prescribed by HIV consultants only

    100mg Tablets
    100mg sachets

    N.B. Oral solution discontinued.

    08.02.03 Rituximab MabThera®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved for consultant specialist prescribing in accordance with NICE TA243, TA226 & TA193.

    100mg/10mL & 500mg/50mL Injection
    1400mg Injection Solution
    unlicensedunlicensed 100mg & 200mg in 0.9% Sodium Chloride Infusion (100mL)
    unlicensedunlicensed 300mg, 350mg, 375mg, 400mg & 450mg in 0.9% Sodium Chloride Infusion (250mL)
    unlicensedunlicensed 500mg, 550mg, 600mg, 650mg, 700mg, 750mg, 800mg & 850mg in 0.9% Sodium Chloride Infusion (500mL)

    10.01.03 Rituximab 500mg/50mL MabThera® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Must be prescribed by Rheumatology Consultant in accordance with NICE TA308 & TA195 for the treatment of rheumatoid arthritis and anti-neutrophil cytoplasmic antibody-associated vasculitis.

    see Section 8.2.3 (for Haematology)

    02.08.02 Rivaroxaban 10mg, 15mg & 20mg Xarelto®

    Refer to NICE TA256/TA261/TA287/TA335 AND anti-coagulation guidelines.

    L&D: 10mg tablets also approved for 2nd line use in needle-phobic patients for thromboprophylaxis in patients with temporary limb immobilisation by the emergency department doctors (dose = 10mg once daily).

    Rivaroxaban is not authorised for thromboprophylaxis in patients with prosthetic heart valves, including patients who have undergone TAVR, and should not be used in such patients. See MHRA update below.

    02.08.02 Rivaroxaban 2.5mg  Xarelto®

    Refer to NICE TA607

    For specialist initiation only

    04.11 Rivastigmine  4.6mg/24hours, 9.5mg/24hours

    Restricted - to patients who are nil by mouth AND
    Restricted to prescribing by Consultant Psychiatrists, Neurologists and physicians specialising in the care of the elderly, with continuation by GPs, in accordance with NICE TA217.
    04.11 Rivastigmine  1.5mg & 6mg Capsules

    Restricted to prescribing by Consultant Psychiatrists, Neurologists and physicians specialising in the care of the elderly, with continuation by GPs, in accordance with NICE 217.
    04.07.04.01 Rizatriptan 5mg, 10mg 

    Last-line choice. Specialist recommendation only.

    15.01.05 Rocuronium Bromide  50mg/5mL & 100mg/10mL Injection
    03.03.03 Roflumilast Daxas® For respiratory specialist prescribing in accordance with
    NICE TA 461.
    09.01.04 Romiplostim Nplate® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Indicated for the treatment of chronic thrombocytopenic purpura in splenectomised patients

    Recommended for the treatment of chronic immune thrombocytopenic purpura in accordance with NICE TA221

    250microgram Injection
    04.09.01 Ropinirole  500micrograms, 2mg tablets
    2mg, 4mg & 8mg modified-release tablets
    02.12 Rosuvastatin  Restricted to 4th-line use in familial hypercholesterolaemia and secondary prevention where target levels have not been met with other statins.
    14.04 Rotavirus vaccine Rotarix®
    04.09.01 Rotigotine Neupro®

    1mg, 2mg, 4mg, 6mg & 8mg Transdermal 24 hour patch

    Restricted Item  Only for patients who are nil by mouth.

    For conversion calculations from levodopa and dopamine agonists, refer to Trust Guideline 336 - The Management of Patients with Parkinson’s Disease In an Emergency and when Nil By Mouth. Also see attached protocol from these guidelines.

    Please note doses are different when used for Restless Leg Syndrome - see BNF or SPC for further information

    08.01.05 Rucaparib Rubraca®

    FOR ALL PRESCRIBING - Blueteq or High cost drug form required - see link from Formulary Home Page.

    RESTRICTED USE - To be used only in accordance with the following NICE TA (s) - Cancer Drugs Fund

    08.01.05 Ruxolitinib Jakavi® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    5mg, 10mg & 15mg Tablets

    Approved in accordance with NICE TA386
    02.05.05.02 Sacubitril and valsartan Entresto®

    24mg/26mg, 49mg/51mg, 97mg/103mg
    Must only be prescribed in accordance with NICE TA388. Can only be initiated by a heart failure specialist.
    N.B. For hospital initiated prescriptions a completed Patient Initiation Form must be handed in to Pharmacy with the first prescription.This is on Evolve.

    03.01.01.01 Salbutamol 

    Short-acting beta-agonist

     Salbutamol 100mcg/dose CFC free MDI +/- spacer

    Easyhaler Salbutamol 100mcg/dose DPI - as agreed December 2019 JPC most cost effective low carbon option

     

    07.01.03 Salbutamol 

    500microgram/1mL & 5mg/5mL Injection

    03.01.01.01 Salbutamol (IV)  5mg in 5mL ampoule for infusion - Must be diluted before use
    500micrograms in 1mL Injection
    03.01.01.01 Salbutamol 2.5mg/2.5mL, 5mg/2.5mL 
    13.07 Salicylic Acid  Verrugon®

    50% Ointment

    Primary care & out-patients - self-care (purchase OTC)

    12.03.05 Saliva Artificial  Biotene Oralbalance®
    12.03.05 Saliva Artificial 

    Contract brands vary. Please prescribe generically.

    03.01.01.01 Salmeterol 

    Long-acting beta-agonist

    50micrograms per metered dose Accuhaler
    25micrograms Evohaler

    If concomitantly prescribed with an inhaled corticosteroids, consider using an ICS/LABA combination inhaler.

    10.01.03 Sarilumab 150mg, 200mg  FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    Approved in accordance with: NICE TA485 for moderate to severe rheumatoid arthritis.
    01.07.02 Scheriproct®  

    Ointment and suppositories.

    N.B. not routinely stocked at L&D.

    10.01.03 Secukinumab 150mg Cosentyx®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Restricted to prescribing by Consultant Rheumatologist for the treatment of ankylosing spondylitis in accordance with NICE TA407.

    13.05.03 Secukinumab 150mg Cosentyx® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved for prescribing by Dermatology consultants in accordance with NICE TA350 for the treatment of plaque psoriasis.
    04.09.01 Selegiline Zelapar®

    For patients with swallowing difficulties.

    04.09.01 Selegiline 5mg, 10mg 
    06.01.02.03 Semaglutide 0.25mg, 0.5mg, 1mg 

    Second choice

    Only to be initiated by Specialist Diabetes team in line with JPC guidance

    01.06.02 Senna  7.5mg tablets
    7.5mg in 5ml syrup
    04.03.03 Sertraline  50mg & 100mg Tablets
    09.05.02.02 Sevelamer Carbonate 

    See shared care guidance.

    N.B. generic available now.

    09.05.02.02 Sevelamer Carbonate 

    See shared care guidance.

    For patients with swallowing difficulties.
    09.05.02.02 Sevelamer Hydrochloride  Renagel®

    See shared care guidance.

    15.01.02 Sevoflurane 
    02.05.01 Sildenafil Revatio® 20mg tablets

    High Cost Drug for pulmonary hypertension. Can ONLY be initiated in a tertiary centre (specialist pulmonary centre). Can prescribe for continuing treatment.

    N.B. Some patients may be on 25mg or 50mg tablets (other brands or generic). This is off-label use.
    07.04.05 Sildenafil 25mg, 50mg  Must prescribe generically.
    Restricted Item Only prescribable on the NHS for erectile dysfunction if fulfil NHS SLS criteria (listed in part XVIIIB of the Drug Tariff).

    13.10.01.01 Silver Sulfadiazine 1% Flamazine®
    05.03.03.02 Simeprevir 150mg Olysio® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Recommended in combination with peginterferon alfa and rivavirin as an option for treatment of chronic hepatitis C infection of genotype 1 and 4 in adults, in accordance with NICE TA331.

    Restricted - to be prescribed only by a Consultant Gastroenterologist/Hepatologist

    01.01.01 Simeticone Infacol®

    Restricted to use in the Endoscopy Unit for removal of bubbles before procedures.

    Inpatient use only

    03.09.02 Simple Linctus, BP  200mL Sugar Free Linctus - Available to purchase over the counter
    02.12 Simvastatin  10mg, 20mg & 40mg Tablets
    06.01.02.03 Sitagliptin 25mg, 50mg, 100mg Januvia®
    09.08.01 Sodium Benzoate 2g in 10mL 

    For paediatric patients.

    Kept in the L&D Pharmacy EDC for use prior to patient transfer to specialist hospital.

    09.02.01.03 Sodium Bicarbonate  500mg Capsules
    09.02.02.01 Sodium Bicarbonate  100mL 8.4% IV Infusion
    10mL 8.4% Pre-filled Syringe
    1.26% IV Infusion
    8.4% Injection
    12.01.03 Sodium Bicarbonate 5% 
    18 Sodium bicarbonate 8.4% 

    Urinary alkalinisation.
    TCAs and class Ia and Ic antiarrhythmic drugs.

    L&D - Kept in ED - IV fluid cupboard and Pharmacy EDC

    BHT - Kept in Accident & Emergency, ICU, Coronary Care Ward and Delivery Suite Theatre

     

    03.01.05 Sodium Chloride  0.9% intravenous solution used as a nebuliser solution and diluent.
    09.02.01.02 Sodium Chloride Slow Sodium® 600mg Sustained Release Tablets
    Contains approximately 10mmol each of sodium and chloride
    11.08.01 Sodium Chloride 0.9% Minims® Saline
    12.02.02 sodium chloride 0.9% 

    For Paediatrics only.

    Self-care in Primary care (can be purchase OTC).

    09.02.01.02 Sodium Chloride 1mmol/1mL 

    For Paediatrics

    03.07 Sodium chloride 3% (Hypertonic) MucoClear® 3% Nebuliser Solution
    09.02.01.02 Sodium Chloride 30% (5mmol/ml) 

    unlicensedunlicensed
    Contains 5mmol/mL

    11.08.01 Sodium Chloride 5%  Preservative-free Eye Ointment
    Preservative-free eye drops x 10ml
    03.07 Sodium chloride 7% (Hypertonic) Nebusal® 7% Nebuliser Solution
    09.02.02.01 Sodium Chloride and Glucose Intravenous Infusion  500mL & 1L Glucose 4%/Sodium chloride 0.18% IV Infusion
    Glucose 5%/Sodium Chloride 0.45% IV Infusion
    Glucose 5%/Sodium Chloride 0.9% IV Infusion
    09.02.02.01 Sodium Chloride Intravenous  0.45% 500mL IV Infusion
    0.9% 50mL, 100mL, 250mL 500mL & 1L IV Infusion
    500mL 0.9%, 1.8%, 2.7% Polyfusor IV Infusion
    30% 10mL Injection
    01.01.02 Sodium citrate 0.3M  For maternity use only.
    06.06.02 Sodium Clodronate 

    400mg, 800mg Tablets

    09.01.01.01 Sodium Feredetate Sytron® Restricted to paediatric use. For adults prescribe ferrous fumarate if liquid required.
    Equivalent to 27.5mg elemental iron/5mL
    05.01.07 Sodium fusidate 250mg  For penicillin resistant staphylococcus or according to local guidelines or on microbiology advice.

    Must always be prescribed with another antobiotic.



    11.08.01 Sodium Hyaluronate 0.1% or 0.2% 
    11.08.01 Sodium hyaluronate 0.15% with trehalose 3% eye drops Thealoz Duo®

    For treatment of severe dry eye

    Secondary care: Prescribe generically.

    Primary care: Prescriptions should be changed to the most cost effective brand once care is transferred 

    PRESERVATIVE FREE multidose bottle can be used for up to 3 months after opening

    11.08.01 Sodium Hyaluronate 0.4% Vizhyal®

    For treatment of severe dry eye

    Secondary care: Prescribe generically.

    Primary care: Prescriptions should be changed to the most cost effective brand (currently Vizhyal) once care is transferred 

    Preservative free multidose bottle can be used for 3 months from opening

    20 Sodium Hyaluronate 800mg/50mL (1.6%), Sodium Chondroitin Sulfate 1g/50mL (2%) iAluRil®

    Restricted to Consultant Urologist use only, once all other treatments have failed.

    18 Sodium nitrite 3% 

    For cyanide toxicity.

    L&D - Kept in ED antidote cupboard.

    BHT - Kept in ED

    09.08.01 Sodium phenylbutyrate 1g in 5mL 

    unlicensed unlicensed

    For paediatric patients.

    Kept in the L&D Pharmacy EDC for use prior to patient transfer to specialist hospital.

    01.06.02 Sodium Picosulfate  5mg in 5ml elixir
    02.13 Sodium Tetradecyl Sulphate Fibro-Vein® 1% injection (2mL)
    3% Injection (2mL)

    Restricted - prescribing by vascular team only in accordance with NICE CG 168 Varicose veins in the legs.
    18 Sodium thiosulphate 50% 

    For cyanide toxicity.

    L&D - Kept in ED antidote cupboard.

    BHT - Kept in ED (stocked as Nithiodate)

    04.08.01 Sodium Valproate Epilim®

    200mg & 500mg Enteric Coated Tablets
    100mg Crushable Tablets
    200mg/5mL Sugar-free liquid

    Prescribing generically or by brand is discretionary.

    See bottom of section for latest MHRA guidance on pregnancy prevention programme (Sept 18) and patient information toolkit (May 2018) and COVID 19 temporary measures.

    04.08.01 Sodium Valproate Epilim® Chrono

    200mg, 300mg & 500mg Controlled Release Tablets. May be given once or twice daily.

    Prescribing generically or by brand is discretionary.

    See bottom of section for latest MHRA guidance on pregnancy prevention programme (Sept 18) and patient information toolkit (May 2018) and COVID 19 temporary measures.

    04.08.01 Sodium Valproate Episenta®

    150mg & 300mg Prolonged Release Capsules

    Prescribing generically or by brand is discretionary.

    See bottom of section for latest MHRA guidance on pregnancy prevention programme (Sept 18) and patient information toolkit (May 2018) and COVID 19 temporary measures.

    04.08.01 Sodium Valproate Episenta®

    300mg/3mL Injection

    Oral and IV bioavailability similar. Patients already satisfactorily treated with oral sodium valproate may be continued at their current dosage. The total daily dose should be divided in three to four single slow intravenous injections or should be given by continuous or repeated infusion.

    See bottom of section for latest MHRA guidance on pregnancy prevention programme (Sept 18) and patient information toolkit (May 2018) and COVID 19 temporary measures.

    09.02.01.01 Sodium zirconium cyclosilicate Lokelma®

    For use in accordance with the following NICE TA(s)

    05.03.03.02 Sofosbuvir / velpatasvir 400mg/100mg Epclusa®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Restricted - to be initiated only by a Consultant Hepatologist in accordance with NICE TA430  for the treatment of chronic hepatitis C.

    05.03.03.02 Sofosbuvir 400mg Sovaldi®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Indicated in combination with ribavirin, with or without peginterferon alfa for chronic hepatitis C infection of genotypes 1, 3, 4, 5 or 6 in patients with compensated liver disease.

    Restricted - to be initiated only by a Consultant Gastroenterologist/Hepatologist

    05.03.03.02 Sofosbuvir 400mg/ Velpatasvir 100mg/ Voxilaprevir 100mg Vosevi®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Restricted - to be initiated only by a Consultant Hepatologist in accordance with NICE TA507 for the treatment of chronic hepatitis C.

    07.04.02 Solifenacin  10mg Tablets
    5mg Film Coated Tablets
    07.04.01 Solifenacin and Tamsulosin Vesomni® Solifenacin 6mg/Tamsulosin 0.4mg Film Coated Tablets

    Restricted for the treatment of moderate to severe symptoms not adequately responding to monotherapy with alpha-blockers.
    06.05.01 Somatropin 

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    Restricted - prescribing by Consultant Endocrinologists or Paediatricians only, in accordance with NICE TA64 or NICE TA188.

    Several different brands are available, to avoid switching between brands it is recommended to prescribe by brand name.

    Preparations as agreed in PAC Policy (Please see the link below)

    08.01.05 Sorafenib 200mg Nexavar®

    HIgh cost drug (Cancer Drug Fund).

    Prescribing by specialists in line with NICE TA474 and TA535.

    02.04 Sotalol  40mg & 80mg Tablets
    Non-cardioselective beta-blocker with additional class III anti-arrhythmic activity used for prophylaxis in paroxysmal supraventricular arrhythmias.
    02.02.03 Spironolactone 25mg, 50mg & 100mg 
    02.02.03 Spironolactone 50mg in 5mL 

    Only use if tablets unsuitable. N.B. tablets can be crushed and mixed with water for enteral feeding tube administration.

    Standard strength liquid is 50mg/5ml as per RCPCH/NPPG guidance - RCPCH/NPPG Standardised strengths of unlicensed liquids

    20 St Marks solution 

    Please refer to attached sheet for information on how to make up.

    On discharge patients will be given a patient information leaflet and will purchase the ingredients for this solution.

    13.11.07 Sterile Larvae (Maggots) LarvE® BB50, BB100, BB200, BB300& BB400 Dressing

    Restricted - Only to be prescribed on recommendation of a Specialist
    02.10.02 Streptokinase 1.5 Mega Unit  Restricted - Only to be prescribed under specialist supervision for acute STEMI.
    05.01.09 Streptomycin Sulphate 1g  Restricted - Microbiology or Consultant approval required.
    unlicensedunlicensed
    01.03.03 Sucralfate  1g tablets
    1g in 5ml suspension

    N.B. This unlicensed product is very expensive in primary care (including our FP10 prescriptions) and is not always available. Please prescribe on hospital out patient prescriptions to ensure patients obtain supply from the hospital.

    The oral suspension can be administered rectally as per the approved protocol below. For Gastroenterology consultant prescribing only.
    13.02.02 Sudocrem® 

    Barrier preparation.

    Self-care in Primary Care (purchase OTC).

    15.01.06 Sugammadex Bridion® 100mg/1mL Injection

    Restricted to licensed indications: sign out of CD cupboard.
    01.05.01 Sulfasalazine 

    500mg e/c and non e/c tablets
    500mg suppositories
    250mg/5ml suspension - RESTRICTED : paediatric patients only

    10.01.03 Sulfasalazine  500mg Enteric Coated Tablets
    250mg/5mL Suspension

    To be prescribed by Consultant Rheumatologist for the treatment of active inflammatory arthritis in adult patients in accordance with JPC Shared Care Guidelines.
    04.02.01 Sulpiride 

    200mg Tablets

    04.07.04.01 Sumatriptan 

    10mg or 20mg per metered dose Nasal Spray

    Not for children under 12 years

    04.07.04.01 Sumatriptan 50mg & 100mg  
    04.07.04.01 Sumatriptan 6mg/0.5mL 

    Stock is held in the L&D Emergency Drug Cupboard

    08.01.05 Sunitinib Sutent® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in line with NICE TA's below.
    13.08.01 Sunsense® Ultra 

    SPF 50+ roll-on or bottle pump.

    N.B. Must write 'ACBS' on FP10 borderline substance.

    May be prescribed for skin protection against ultraviolet radiation and/or visible light in abnormal cutaneous photosensitivity causing severe cutaneous reactions in genetic disorders (including xeroderma pigmentosum and porphyrias), severe photodermatoses (both idiopathic and acquired) and in those with increased risk of ultraviolet radiation causing severe adverse effects due to chronic disease (such as haematological malignancies), medical therapies and/or procedures

    15.01.05 Suxamethonium Chloride  100mg/2mL Injection
    100mg/2mL Pre-filled Syringe
    08.02.02 Tacrolimus 

    For continuation in transplant patients. Prescribe same brand.

    Red Hospital only for new transplant patients.

    Standard strength liquid is 5mg/5ml as per RCPCH/NPPG guidance - RCPCH/NPPG Standardised strengths of unlicensed liquids

    13.05.03 Tacrolimus Protopic® 0.03% & 0.1% Ointment

    Approved in accordance with NICE TA82 for the treatment of mild atopic eczema.
    07.04.05 Tadalafil 10mg, 20mg 

    Only prescribable on the NHS for erectile dysfunction if fulfil NHS SLS criteria (listed in part XVIIIB of the Drug Tariff). Approved for use by the Urology consultants.

    N.B. the 5mg daily dose has not been approved at DTC for any indication and for erectile dysfunction  is considered a low value medicine by NHSE. This is therefore unlikely to be continued in Primary care and should not be prescribed.

    Amber Traffic Light  Approved for 2nd-line use for the treatment of severe Raynaud's disease when prescribed by a Consultant Rheumatologist. This indication is off-label.

    11.06 Tafluprost (Preservative Free) 15micrograms/ml Saflutan®
    08.03.04.01 Tamoxifen 10mg, 20mg 
    07.04.01 Tamsulosin  400microgram modified release capsule
    20 Taurolodine and Citrate 4% TauroLock®

    Approved for use at Bedford Hospital in accordance with Trust Guideline when recomended for use by Vascular Access Nurse

    20 Taurolodine, Citrate 4% and Urokinase 25,000units TauroLock U25,000®

    Approved for use at Bedford Hospital in accordance with Trust Guideline when recomended for use by Vascular Access Nurse

    Recommended at the Luton & Dunstable Hospital only when there is a shortage of urokinase

    08.01.03 Tegafur with Uracil Uftoral®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage

    Restricted to prescribing according to the NICE TA(s) below.

    05.01.07 Teicoplanin 

    200mg & 400mg Injection
    Loading dose needed - Initial 3 doses given 12 hourly then ONCE daily.

    These must only be prescribed in accordance with the Trust's antimicrobial guideline or by recommendation from the Consultant Microbiologist.

    Please ensure the new dosing reflected in the online BNF is followed.

    Serious infections caused by Gram-positive bacteria (e.g. complicated skin and soft-tissue infections, pneumonia, complicated urinary tract infections) by intravenous injection/infusion or intramuscular injection

    Initially 6 mg/kg every 12 hours for 3 doses, then 6 mg/kg once daily.

    Bone and joint infections by intravenous injection/infusion

    12 mg/kg every 12 hours for 3–5 doses, then (by intravenous injection or by intravenous infusion or by intramuscular injection) 12 mg/kg once daily.

    Surgical prophylaxis by intravenous injection

    400 mg, to be administered up to 30 minutes before the procedure.

    Surgical prophylaxis in open fractures by intravenous infusion

    800 mg, to be administered up to 30 minutes before skeletal stabilisation and definitive soft-tissue closure.

    04.01.01 Temazepam  When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfill the legal requirements of controlled drug prescriptions. e.g. Supply fourteen (14) tablets (signed).

    10mg Tablets
    10mg/5mL Sugar free Elixir
    05.01.01.02 Temocillin 1g  Restricted - Microbiology Approval required.
    08.01.05 Temozolomide Temodal® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in accordance with NICE TA23 & TA121
    05.03.01 Tenofovir 245mg, Efavirenz 600mg and Emtricitabine 200mg Atripla® Efavirenz 600mg/Emtricitabine 200mg/Tenofovir Disoproxil
    245mg

    Prescribe as Truvada PLUS generic efavirenz where possible.

    Restricted - must be prescribed by HIV consultants only
    05.03.01 Tenofovir alafenamide, Elvitegravir, Cobicistat & Emtricitabine Genvoya® Contains 150 mg of elvitegravir, 150 mg of cobicistat, 200 mg of emtricitabine and tenofovir alafenamide fumarate equivalent to 10 mg of tenofovir alafenamide.

    Restricted - prescribing by HIV Consultants only in accordance with BHIVA guidelines and NHSE Clinical Commissioning policy.
    05.03.01 Tenofovir and Emtricitabine Truvada® Restricted - must be prescribed by HIV consultants only

    Emtricitabine 200mg/Tenofovir 245mg Tablets
    05.03.01 Tenofovir Disproxil Viread® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage - For Hepatitis B patients only.

    245mg Tablets : Restricted - must be prescribed by Consultant Hepatologist for the treatment of Chronic hepatitis B in accordance with NICE TA173.

    204mg tablets in combination with other antiretrovirals: To be prescribed by HIV consultants only.

    05.03.01 Tenofovir, cobicistat, elvitegravir & emtricitabine Stribild® Restricted - prescribing by HIV Consultants only in accordance with BHIVA guidelines.

    Contains Tenofovir 245mg/Cobicistat 150mg/Elvitegravir 150mg/Emtricitabine 200mg Tablets
    13.10.02 Terbinafine 1% 
    05.02.05 Terbinafine 250mg 
    05.02.05 Terbinafine 250mg 

    Restricted - for Dermatology.

    Low priority for funding for the treatment of Fungal Nail Infections
    Microbiology approval required for all other uses.

    03.01.01.01 Terbutaline  500micrograms in 1mL Injection
    03.01.01.01 Terbutaline 500micrograms/ metered dose  Short-acting beta-agonist


    03.01.01.01 Terbutaline 5mg/ 2mL 
    08.02.04 Teriflunomide Aubagio®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    14mg Film Coated Tablets

    For specialist prescribing in-line with NICE TA303

    06.06.01 Teriparatide Forsteo® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    Restricted - secondary care prescribing in-line with NICE TA161
    250microgram/1mL Injection
    06.05.02 Terlipressin Glypressin® 1mg Injection Solution

    Restricted - to initiation by Consultant Gastroenterologists for patients with bleeding varices not amenable to non-pharmacological intervention.
    06.01.06 Test strips 

    Accu-Chek Inform 11® Reagent Strips

    06.01.06 Test Strips Combur7®

    Combur7® Test Strips

    06.04.02 Testosterone and Esters Sustanon 250®

    250mg/1mL Injection

    When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

    06.04.02 Testosterone and Esters 50mg/5g Testogel®

    Restricted - For prescribing for hypogonadism by endocrinologists or for gender dysphoria.

    5g sachets are available again following a shortage.

    Is also available as a pump dispenser but this is a different dose. Please refer to SPC.

    When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

    06.04.02 Testosterone Enantate 

    Restricted - Prescribing in Gender Dysphoria only on the advice of a specialist centre under shared care arrangements

    06.04.02 Testosterone gel  Tostran® Testim®

    Restricted - Prescribing in Gender Dysphoria only on the advice of a specialist centre under shared care arrangements

    06.04.02 Testosterone undecanoate Nebido®

    Restricted - Prescribing in Gender Dysphoria only on the advice of a specialist centre under shared care arrangements

    14.05.02 Tetanus immunoglobulin  Contact Consultant Microbiologist - Pathology
    04.09.03 Tetrabenazine  25mg Tablets
    11.07 Tetracaine Hydrochloride Minims® Amethocaine Hydrochloride 1% Single Dose - Preservative free
    06.05.01 Tetracosactide Synacthen® 250microgram/1mL Injection
    06.05.01 Tetracosactide 1mg Synacthen Depot ® Restricted to Rheumatology consultants only.
    For acute inflammatory arthritis in patients where current treatment is inappropriate, ineffective or not tolerated.
    Dose is one stat injection. See algorithm below.
    05.04.01 Tetracyclines  For treatment of malaria on specialist advice only.
    08.02.04 Thalidomide Pharmion®

    50mg Capsules

    NOTE: Patient, prescriber and supplying pharmacy must comply with a pregnancy prevention programme. Every prescription must be accompanied by a complete Prescription Authorisation Form.
    1. Restricted -to prescribing by Oncologists only.
    2. Restricted - prescribing by Haematologists only in accordance with NICE TA 228. Blueteq or high cost drug form required.

    03.01.03 Theophylline Uniphyllin® Continus

    Prescribe by brand - varying release profile

    200mg, 300mg & 400mg Sustained Release Tablets

     

    03.01.03 Theophylline 250mg Nuelin® SA Prescribe by brand - varying release profile

    N.B. Most expensive theophylline product.



    09.06.02 Thiamine 

    50mg & 100mg Tablets
    Can be crushed and mixed with water to administer down an enteral feeding tube.

    Alcoholism - only prescribe in accordance with NICE and Regional Medicines Optimisation Committee (RMOC) Guidance - see attachments.

    15.01.01 Thiopental 500mg 
    02.09 Ticagrelor 90mg Brilique® 1st line in combination with aspirin in ACS as per trust protocol and NICE TA420.

    Strong CYP3A4 inhibitors (e.g. clarithromycin, ketoconazole, itraconazole, voriconazole,nefazodone, ritonavir and atazanavir) interact with ticagrelor and increase its plasma level by up to five times. Please be mindful of drug interactions when prescribing this.
    02.09 Ticagrelor 90mg Brilique®

    1st line in combination with aspirin in ACS as per trust protocol and NICE TA420.

    Orodispersible tablet will dissolve on the tongue for patients with swallowing difficulties or can be dispersed in water to be flushed down a nasogastric tube.

    Strong CYP3A4 inhibitors (e.g. clarithromycin, ketoconazole, itraconazole, voriconazole,nefazodone, ritonavir and atazanavir) interact with ticagrelor and increase its plasma level by up to five times. Please be mindful of drug interactions when prescribing this.

    05.01.03 Tigecycline 50mg Tygacil® Restricted - Microbiology approval required.
    13.05.03 Tildrakizumab Ilumetri 100mg®

    FOR ALL PRESCRIBING - Blueteq or High Cost Drug Form Required - see link from Formulary Home Page. 

    Approved in accordance NICE TA (s) below:-

    13.04 Timodine® 

    Mild

    Hydrocortisone with benzalkonium chloride, dimeticone and nystatin.

    Continence team initiation.

     

    11.06 Timolol  0.25% & 0.5% Eye Drops
    11.06 Timolol  0.25%, 0.5% Minims
    Restricted to patients who are allergic to preservatives.
    02.08.01 Tinzaparin  1st line for treatment and prophylaxis of DVT and PE:

    8,000 Units in 0.8mL Pre-Filled Syringe
    10,000 Units in 0.5mL Pre-Filled Syringe
    12,000 Units in 0.6mL Pre-Filled Syringe
    14,000 Units in 0.7mL Pre-Filled Syringe
    16,000 Units in 0.8mL Pre-Filled Syringe
    18,000 Units in 0.9mL Pre-Filled Syringe

    40,000 Units in 2ml vial

    03.01.02 Tiotropium Spiriva Respimat ®

    Long-acting antimuscarinic



    2.5micrograms per metered dose - inhaler (Respimat)

    03.01.02 Tiotropium  Braltus®

    Long-acting antimuscarinic. Branded generic equivalent to Spiriva.

    Dry powder inhaler (Zonda), 10microgram capsule per delivered dose of tiotropium.

    03.01.02 Tiotropium Spiriva Handihaler®

    Long-acting antimuscarinic

    18microgram Capsules - dry powder inhaler (Handihaler). Delivered dose is 10micrograms

    03.01.04 Tiotropium / olodaterol® Spiolto Respimat

    Long-acting anti-muscarinic and long-acting beta agonist

    Tiotropium 2.5micrograms/ olodaterol 2.5micrograms Inhaler solution.

    02.09 Tirofiban 250microgram in 1ml Aggrastat® Restricted - Only to be prescribed under Consultant Cardiologist authorization and in accordance with NICE TA47 which has been partially updated by NICE CG 94 - Unstable angina and NSTEMI: the early management of unstable angina and non-ST-segment-elevation myocardial infarction.

    08.01.05 Tisagenlecleucel Kymriah®

    Cancer Drug Funded in accordance with criteria in NICE TA's below.

     

    08.01.05 Tivozanib 890mcg, 1340mcg Fotivda®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    For specialist prescribing in line with NICE TA512.

    05.01.04 Tobramycin 300mg/4mL  Restricted - initiation by consultant Paediatricians specialising in Cystic Fibrosis for the management of chronic pulmonary infection due to Pseudomonas aeruginosa in patients with cystic fibrosis aged 6 years and older if nebulised colistin is not tolerated or if clinical progress is unsatisfactory.

    High Cost Drug funded by NHS England for this indication only.


    05.01.04 Tobramycin 80mg/2mL  Must only be prescribed in accordance with the Luton & Dunstable Trust's Antimicrobial Guidelines or by recommendation from a Consultant Microbiologist.
    05.01.04 Tobramycin inhaler 28mg  TOBI Podhaler® Restricted - initiation by consultant Paediatricians specialising in Cystic Fibrosis for the management of chronic pulmonary infection due to Pseudomonas aeruginosa in patients with cystic fibrosis aged 6 years and older in accordance with NICE TA 276

    To be used second line to tobramycin nebuliser solution (Bramitob®)

    High cost drug funded by NHS England for this indication only.
    10.01.03 Tocilizumab RoActemra®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    162mg pre-filled syringe for subcutaneous injection
    80mg, 200mg, 400mg solution for intravenous infusion

    Must be prescribed by a Rheumatology consultant in accordance with the NICE TA's below.

    10.01.03 Tofacitinib Xeljanz®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    Approved in accordance with the NICE TA's below.

    01.05.03 Tofacitinib 5mg, 10mg Xeljanz®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Restricted to prescribing by Consultant Gastroenterologist in accordance with NICE TA547.

    06.01.02.01 Tolbutamide 500mg 

    Restricted - Not to be used as a first choice treatment due to drug interactions.

    07.04.02 Tolterodine 

    Immediate release tablets are first line treatment

    07.04.02 Tolterodine 

    4mg XL capsules


    Neditol XL is preferred brand in Primary Care

    06.05.02 Tolvaptan 15mg 

    Hyponatraemia due to lung cancer is funded by NHSE.

    FOR SIADH PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Tolvaptan is recommended as an option for treating hyponatraemia secondary
    to SIADH for patients who do not require chemotherapy

    • with proven SIADH with serum sodium symptoms, where fluid restriction and a one week trial of demeclocycline treatment have failed or are contra-indicated.
    • Course of treatment should not exceed 10 days.
    • Treatment should be initiated in secondary care and monitored by a specialist.
    • Prescribing should remain in secondary care. Prescribing in primary care is
      not recommended.
    • Trusts must notify CCGs on initiation of treatment and provide clinical and
      outcome data.
    04.08.01 Topiramate  25mg, 50mg & 100mg Tablets

    15mg & 25mg Sprinkle Capsules - may be swallowed whole or opened and sprinkled on a teaspoon of soft food (must be swallowed immediately and not chewed).

    Prescribing generically or by brand is discretionary.
    08.01.05 Topotecan Hycamtin® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    250microgram & 1mg Capsules

    Approved in accordance with NICE TA389, TA184 & TA183.
    08.01.05 Trabectedin Yondelis®

    0.25mg and 1 mg powder for concentrate for solution for infusion.

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in accrodance with NICE TA185 and TA389

     

    04.07.02 Tramadol  50mg Capsules
    50mg Soluble Tablets

    When prescribing this product on TTA's and outpatient prescriptions, the quantity to be supplied must be stated in words and figures and counter signed in order to fulfil the legal requirements of controlled drug prescriptions. e.g. Please supply thirty (30) capsules (signed).
    04.07.02 Tramadol  100mg/2mL Injection
    10.01.02.02 Tramcinolone Hexacetonide 20mg/mL 

    Prescribing by Consultant Rheumatologist only for use in paediatric patients.

    08.01.05 Trametinib Mekinist®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    Restricted - for Oncologists in line with the NICE TA's below.

    02.11 Tranexamic Acid 500mg 

    02.11 Tranexamic Acid 500mg in 5mL 
    12.03.04 Tranexamic Acid Mouthwash 5% 
    08.01.05 Trastuzumab Herceptin® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    150mg Injection
    100mg & 160mg Injection for Infusion
    147mg - 1200mg in 0.9% Sodium Chloride Infusion (250mL)

    Approved in accordance with NICE TA's below.
    08.01.05 Trastuzumab emtansine Kadcyla®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved for use in accordance with the following NICE TA(s):

    11.06 Travoprost 40mcg/mL 
    04.03.01 Trazodone 

    For initiation by Mental Health specialist from ELFT only

    08.01.05 Tretinoin 10mg 

    Restricted to prescribing by Consultant Haematologists for early treatment of suspected acute promyelocytic leukaemia (APL), a haematological emergency.

    LDH: Stocked in the Emergency Drug Cupboard.

    N.B. Also known as ATRA (all-trans retinoic acid) in clinical trials.

    10.01.02.02 Triamcinolone Acetonide Adcortyl® 10mg/1mL Injection
    10.01.02.02 Triamcinolone Acetonide 40mg/1mL Kenalog®
    06.03.02 Triamcinolone acetonide Injection Kenalog

    40mg in 1mL

    04.02.01 Trifluoperazine 

    1mg & 5mg Tablets

    N.B. Price increase, now very expensive.

    For initiation by Mental Health specialist from ELFT only

    04.06 Trifluoperazine 

    1mg & 5mg Tablets
    5mg/5mL Solution

    08.01.03 Trifluridine-tipiracil 15mg/6.14mg, 20mg/8.19mg Lonsurf® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    Restricted - prescribing by consultant Oncologists for previously treated metastatic colorectal cancer in accordance with NICE TA 405 and NHSE.
    04.09.02 Trihexyphenidyl 

    2mg & 5mg Tablets
    5mg/5mL Syrup

    05.01.08 Trimethoprim  100mg & 200mg Tablets
    50mg/5mL Suspension

    N.B.Contraindicated in any patient taking methotrexate.
    06.07.02 Triptorelin 3.75mg Gonapeptyl®
    06.07.02 Triptorelin 3mg Decapeptyl®
    06.07.02 Triptorelin SR 11.25mg Decapeptyl®

    When being used for Gender Dysphoria, must only be prescribed on the advice of a specialist centre under shared care arrangements

    20 TROMETAMOL (THAM)  

    3.6% or 7.2% depending on availability.

     

    L&D: stocked on NICU

    BHT: stocked on Meadowbank

    11.05 Tropicamide single use Minims® Tropicamide 0.5% & 1% Single Dose Eye Drops - Preservative free
    07.04.02 Trospium 20mg 
    14.04 Typhoid Live Oral vaccine  Injection - (Typhim VI)
    07.03.05 Ulipristal EllaOne® 30mg Tablets
    Restricted to Luton Sexual Health Clinic only

    Option for emergency contraception in women presenting within 120 hours after unprotected intercourse in patients where an IUD is not a suitable option.
    03.01.02 Umeclidinium Incruse Ellipta®

    Approved by JPC  as a 2nd choice LAMA option for the treatment of COPD.

     

    JPC Bulletin278: Umeclidinium bromide (Incruse®Ellipta®) for the treatment of COPD

    03.01.04 Umeclidinium & vilanterol Anoro Ellipta®

    Approved by JPC  as a 2nd choice LAMA / LABA option for the treatment of COPD

    JPC Bulletin 279: Umeclidinium / Vilanterol (Anora®Ellipta®) for the treatment of COPD

    01.07.02 Uniroid HC 

    Ointment and suppositories.

    Most cost-effective preparation in Primary Care - brand prescribe.

    N.B. not routinely stocked at the L&D

    13.02.01 Urea 10% Eucerin® Intensive

    Self-care in Primary care (purchase OTC).

    13.02.01 Urea 25%  Flexitol®

    Self-care in Primary Care (purchase OTC).

    A5.03.03 Urgotul Silver 

    10cm x 12cm Dressing
    15cm x 20cm Dressing

    Refer to Wound Management Formulary or TVN for appropriate use.

    02.10.02 Urokinase 

    10,000 Units & 25,000 Units Injection

    For CVC occlusion
    Dilute 10 000 units in 2ml 0.9% sodium chloride and follow Trust guidelines (see link).

    Currently Unavailable.

    For Luton & Dunstable Hospital - substitute Taurolock 25000 units:

    Instructions for use:

    Reconstitute Taurolock with the diluent provided (5mL ampoule). Withdraw a 10,000 unit dose (2mL) then follow the procedure on the L&D Trust guideline for a 60 minute dwell time.

    Please note, however, that the manufacturer of Taurolock advise that this is not for systemic use and that it should be aspirated once the dwell time is finished.

    01.09.01 Ursodeoxycholic acid  150mg & 500mg tablets
    250mg capsules
    250mg/5ml sugar-free suspension
    10.01.03 Ustekinumab 45mg, 90mg Stelara® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Restricted to prescribing by Consultant Rheumatologist for the treatment of active psoriatic arthritis in accordance with NICE TA340.
    13.05.03 Ustekinumab 45mg, 90mg Stelara® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in accordance with NICE TA180, TA455 and TA456.

    01.05.03 Ustekinumab 45mg, 90mg, 130mg Stelara®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Restricted to prescribing by Consultant Gastroenterologist for the treatment of active Crohn's disease or moderately to severely active Ulcerative Colitis  in accordance with the following NICE TA(s):

    13.08.01 Uvistat®SPF30 

    N.B. Must write 'ACBS' on FP10 borderline substance.

    May be prescribed for skin protection against ultraviolet radiation and/or visible light in abnormal cutaneous photosensitivity causing severe cutaneous reactions in genetic disorders (including xeroderma pigmentosum and porphyrias), severe photodermatoses (both idiopathic and acquired) and in those with increased risk of ultraviolet radiation causing severe adverse effects due to chronic disease (such as haematological malignancies), medical therapies and/or procedures

    05.03.02.01 Valaciclovir  500mg tablets.

    Valaciclovir is a prodrug of aciclovir. Not for in-patient use.

    Restricted: Luton Sexual Health clinic or for patients who cannot adhere to the 5 x daily aciclovir regime.
    05.03.02.02 Valganciclovir Valcyte® Not NHS. Commissioned by NHS England for cytomegalovirus infection according to licensed indications (see SPC).
    04.02.03 Valproic Acid 250mg, 500mg Depakote® Also known as valproate semisodium.
    Valproate should not be prescribed to female children, female adolescents, women of childbearing potential or pregnant women unless other treatments are ineffective or not tolerated. Initiation by Mental Health Trust.
    02.05.05.02 Valsartan 

    40mg, 80mg & 160mg Capsules

    05.01.07 Vancomycin 125mg  Restricted - only for treatment of C. Difficile for Out-patients and on TTA's. In-patients must be prescribed the injection which can be diluted with water and taken orally.
    05.01.07 Vancomycin 500mg & 1g   Samples must be taken before giving 3rd dose. Give 3rd dose and check levels before giving 4th dose.

    For oral use in the treatment of C.difficile, reconstitute injection vials and give orally (each dose can be further diluted by 30mL). Store vial in fridge for up to 24 hours.

    Refer to Antimicrobial guidelines or Microguides app for more information.
    04.10.02 Varenicline Champix® 500mcg and 1mg Tablets

    Restricted - to be used in accordance with Trust Guidelines, NICE TA123 and Public Health guidance, as second line therapy when NRT has failed.
    14.05.02 Varicella-Zoster immunoglobulin VZIG Contact Consultant Microbiologist and confirm appropriate.

    We can no longer receive FP10s from GP surgeries so a signed order must now be used to order the immunoglobulin.

    Pharmacy must:
    • check all the information is filled out at the point of receiving the signed order or prompt GP/practice nurse to do so if you receive initial call.

    • Process via dispensary, book out to the patient (same batch numbers to be selected and booked out)

    • Give to patient/named courier when they arrive – no counselling.

    The dispenser also needs to fill out the slip that comes in the vials and give to the Antimicrobial Lead Pharmacist.
    06.05.02 Vasopressin Pitressin® unlicensedunlicensed
    Vasopressin is only used when argipressin is unavailable
    15.01.05 Vecuronium Bromide   10mg Injection
    01.05.03 Vedolizumab Entyvio® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    300mg Injection

    Restricted Item 
    08.01.05 Vemurafenib Zelboraf® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Approved in line with NICE TA176 & TA269.
    08.01.05 Venetoclax 10mg, 50mg, 100mg Venclyxto®

    FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
    Approved in accordance with NICE TA's below.

    04.03.04 Venlafaxine  37.5mg & 75mg tablets
    37.5mg modified release tablets
    75mg & 150mg modified release capsules
    02.06.02 Verapamil  40mg, 80mg & 120mg tablets
    120 & 240mg Sustained Release Capsules
    02.06.02 Verapamil  5mg in 2mL Injection
    11.08.02 Verteporfin Visudyne® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    JPC Recommendations:
     To support the use of PDT with verteporfin for the treatment of Chronic Central Serous Retinopathy.
     Approval is subject to patient outcomes being provided (via Blueteq reauthorisation process).
    04.08.01 Vigabatrin Sabril® 500mg Tablets
    500mg Sachets

    May be prescribed generically.
    08.01.04 Vinblastine Sulphate  10mg Injection
    unlicensedunlicensed 5mg - 9mg in 0.9% Infusion (50mL)
    unlicensedunlicensed 5.1mg in 0.9% Sodium Chloride Pre-filled Syringe (10.2mL)
    unlicensedunlicensed 3mg/23mL, 9mg/20mL & 10mg/20mL Syringe

    08.01.04 Vincristine Sulphate  2mg/2mL Injection
    unlicensedunlicensed 1mg & 2mg in 0.9% Sodium Chloride Infusion (50mL)
    unlicensedunlicensed 0.23mg/10mL & 0.26mg/10mL, 0.8mg/10mL, 0.9mg/10mL & 1mg/10mL Syringe
    unlicensedunlicensed 0.46mg/4.6mL, 0.55mg/5.5mL 0.6mg/6mL, 0.9mg/20.9mL, 1mg/21.1mL, 1.2mg/12mL, 1.2mg/21.2mL, 1.3mg/21.3mL, 1.4mg/21.4mL, 1.5mg/21.5mL, 1.7mg/20mL, 1.7mg/21.7mL, 1.8mg/21.8mL & 2mg/20mL Syringe

    Restricted - must seek authorisation from a consultant before prescribing
    08.01.04 Vinorelbine  20mg & 30mg Capsules
    50mg/5mL Injection
    unlicensedunlicensed 38mg, 50mg, 57mg in 0.9% Sodium Chloride Infusion (50mL)

    08.01.05 Vismodegib 150mg Erivedge® FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.

    Only approved in accordance with the National Cancer Drugs Fund List for the treatment of locally advanced or metastatic Basal Cell Carcinoma. See NICE TA489.

    Note: Patient, prescriber, and supplying pharmacy must comply with the manufacturer’s pregnancy prevention programme.
    09.06.07 Vitamin and mineral supplements Forceval Soluble®

    For patients with swallowing difficulties

    09.06.07 Vitamin and mineral supplements Ketovite® Tablets and liquid
    09.06.07 Vitamin and mineral supplements Forceval®
    09.06.02 Vitamin B and C injection Pabrinex®
    09.06.02 Vitamin B Tablets, Compound Strong 

    Can be substituted for Vitamin B Co.

    Not suitable for enteral tube administration. Consider if necessary and prescribe separately thiamine with or without pyridoxine which can be crushed.

    For longer term tube-fed patients, prescribe thiamine with or without pyridoxine separately.

    Alcoholism - except for rare cases, recommended only for short term use. See attached Regional Medicines Optimisation Committee (RMOC) Position Statement.

    09.06.07 Vitamin supplements Renavit® For the dietary management of water-soluble vitamin deficiency in adults with renal failure on dialysis.
    05.02.01 Voriconazole 200mg  Restricted High Cost Drug - Microbiology approval required.
    05.02.01 Voriconazole 50mg, 200mg  Restricted high cost drug– Haematology and Oncology consultants, GUM and solid organ transplant patients. Microbiology approval required for all other uses.

    04.03.04 Vortioxetine  Restricted - only to be initiated by a Consultant Psychiatrist for treating major depressive episodes in accordance with NICE TA367.

    5mg, 10mg & 20mg Film Coated Tablets
    02.08.02 Warfarin 1mg, 3mg & 5mg  Ensure dose is written in patient's yellow book upon discharge and anti-coagulation clinic appointment made.
    09.02.02.01 Water for Injection  10mL & 20mL Ampuole
    13.02.01 White Soft Paraffin BP 
    12.02.02 Xylometazoline Otrivine® 0.1% Nasal drops
    0.1% Spray
    0.05% Paediatric Nasal drops
    In primary care may be purchased over the counter
    01.07.02 Xyloproct® ointment 
    05.03.04 Zanamivir  unlicensedunlicensed. Available on a named patient basis from GlaxoSmithKline for patients who fit the Public Health England criteria.
    Must get advice from Consultant Microbiologist. Contact Pharmacy to order.
    05.03.04 Zanamivir 5mg/blister for inhalation Relenza® Restricted - to be initiated on Consultant Microbiology approval only and in accordance with NICE TA 158/168

    13.02.01 ZeroAQS® 

    Emollient cream. Substitute for aqueous cream.

    N.B. does not contain SLS (sodium lauryl sulfate, a known skin irritant) unlike aqueous cream.

    13.02.01 Zerobase® 

    Emollient cream. Substitute for Diprobase

    13.02.01 Zerocream® 

    Emollient cream. Substitute for E45.

    13.02.01 Zeroderm® 

    Similar to Epaderm & Hydromol

    13.02.01 Zerodouble® Gel  

    Substitute for Doublebase.

    13.02.01 Zeroguent® 

    Emollient cream. Substitute for Unguentum M.

    13.02.01 Zeroveen 

    Colloidal oatmeal containing emollient .

    Substitute for Aveeno (which should not be prescribed). Can be purchased OTC.

    05.03.01 Zidovudine  Restricted - must be prescribed by HIV Consultants only

    100mg & 250mg Capsules
    50mg/5mL Syrup
    200mg/20mL Injection
    05.03.01 Zidovudine and lamivudine  Restricted - prescribing by HIV Consultants only.

    Zidovudine 300mg / lamivudine 150mg
    13.02.02 Zinc and Castor Oil Ointment BP 

    Contains peanut oil.

    Self-care in Primary Care (purchase OTC).

    A5.08.09 Zinc paste 10% bandage Viscopaste®

    N.B. Steripaste was discontinued.

    09.05.04 Zinc Sulphate Solvazinc® 125mg effervescent tablets - containing 45mg of Zinc
    06.06.02 Zoledronic Acid 4mg 

    L&D: For licensed indications in cancer patients.

    Note: Bedford Hospital only currently use 4mg doses for all indications due to cost of 5mg preparation (November 2018)

    06.06.02 Zoledronic Acid 5mg 

    1. For osteoporosis treatment in line with NICE guidelines

    2. Restricted -  Consultant Oncologists for adjuvant treatment in early breast cancer.

    Note: Bedford Hospital only currently use 4mg doses for all indications due to cost of 5mg preparation (November 2018)

    Note: L&D use 2x4mg vials for a 5mg dose due to cost of the 5mg preparation (approved by DTC).

    04.07.04.01 Zolmitriptan 2.5mg 
    04.07.04.01 Zolmitriptan 2.5mg 
    04.01.01 Zolpidem 
    04.01.01 Zopiclone  3.75 & 7.5mg Tablets
    04.02.01 Zuclopenthixol  2mg & 10mg Tablets
    04.02.01 Zuclopenthixol 50mg/1mL, 200mg/1mL Clopixol Acuphase® See Section 04.02.02 for depot preparations

    Restricted - initiation by Consultant Psychiatrist (Mental Health Trust) only.
    IMPORTANT NOTE:- when prescribing, dispensing or administering, check that this is the correct preparation - this preparation is usually used in hospital for an acute episode and should not be confused with depot preparations which are usually used in the community or clinics for maintenance treatment.
    04.02.02 Zuclopenthixol Decanoate 500mg/1mL Clopixol Conc.®

    Specialist initiation and continuation

    Bedfordshire and Luton Joint Formulary